A5046242597- Ferroptosis and cancer prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trace Elements in Health
- Blood disorders and treatments
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
- Vasculitis and related conditions
- MicroRNA in disease regulation
Sir Run Run Shaw Hospital
2023-2025
Zhejiang University
2023-2025
Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, crosstalk between cuproptosis is obscure.We analyzed effect of inducers on copper ionophores-induced death through CCK-8 assay. was studied using immunofluorescence protein soluble-insoluble fraction isolation. GSH assay, qRT-PCR western blot were adopted to explore machinery enhanced cuproptosis. And mouse xenograft model built detect synergy elesclomol-Cu sorafenib in vivo.Herein we found...
Abstract TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) crucial anti-infection mechanism neutrophils. Here we show the influence on NETosis and related mechanisms. We in context pyelonephritis mouse model induced by TcpC-secreting wild-type CFT073 (CFT073 wt ) LPS-induced vitro with or recombinant (rTcpC)-treated neutrophils are inhibited. rTcpC enters through caveolin-mediated endocytosis inhibits production ROS,...