A5079130206- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Breast Lesions and Carcinomas
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Breast Implant and Reconstruction
- Gastrointestinal Tumor Research and Treatment
- Immune Cell Function and Interaction
- Uterine Myomas and Treatments
- Tryptophan and brain disorders
- Renal Diseases and Glomerulopathies
- LGBTQ Health, Identity, and Policy
- Blood properties and coagulation
- Wnt/β-catenin signaling in development and cancer
- Endometrial and Cervical Cancer Treatments
- Fluid Dynamics and Mixing
- Clusterin in disease pathology
- Long-Term Effects of COVID-19
New York University
2019-2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2021-2024
Hofstra University
2020-2023
Northwell Health
2020-2023
XinHua Hospital
2021-2023
Central South University
2019
Zhejiang University
2012
Blockade of the Piezo1 mechanoreceptor decreases myeloid cell suppression immune responses to cancer and polymicrobial sepsis.
RIP1 regulates cell death and inflammation is believed to play an important role in contributing a variety of human pathologies, including immune-mediated inflammatory diseases cancer. While small-molecule inhibitors kinase have been advanced the clinic for CNS indications, oncology indications yet be described. Herein we report on discovery profile GSK3145095 (compound 6). Compound 6 potently binds with exquisite specificity has excellent activity blocking kinase-dependent cellular...
Trichorhinophalangeal syndrome type 1 (TRPS1) has emerged as a reliable immunohistochemistry (IHC) marker for identifying breast origin in metastatic carcinomas. This study investigates the utility of TRPS1 IHC non-breast cytology specimens.
Endometrial cancer is the most common gynecological malignancy in United States. Despite high prevalence amongst cisgender females of this transgender men has not been clearly identified. To date, only four reported cases have described literature.A 36-year-old nulliparous assigned female at birth, premenopausal male underwent a laparoscopic total hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node mapping and omental biopsy after having an endometrial that demonstrated well...
Colorectal cancer (CRC) is the most common malignancy of gastrointestinal tract. The stroma and tumoral microenvironment (TME) represent ecosystem-like biological networks are new frontiers in CRC. present study demonstrates use a novel machine learning-based superpixel approach for whole slide images to unravel this biology. Findings significance include association low proportionated stromal area, high immature percentage, myxoid ratio (MSR) with worse prognostic outcomes Overall,...
Abstract Whether sentinel lymph node biopsy (SLNB) should be performed in patients with microinvasive breast cancer (MIBC) has been a matter of debate over the last decade. MIBC favorable prognosis and while metastasis to axilla is rare, it can impact treatment recommendations. In this study we evaluated clinical histological features both background DCIS including ER, PR, HER-2, number foci MIBC, extent DCIS, nuclear grade, presence comedo necrosis, as well surgical procedures, adjuvant...
Background: Rapid progression and early metastasis remain the main cause of high mortality in epithelial ovarian cancer (EOC) patients. The objective this study was to explore mechanisms EOC detect function leucine-rich alpha-2-glycoprotein 1 (LRG1) modulating pathologic process. Methods: Ultracentrifugation initially performed extract exosomes from urine samples patients healthy female subjects. Mass spectrometry (MS) employed analyze differentially expressed proteins. Survival analysis...
Colorectal cancer is a heterogenous disease with striking biological diversity. carcinoma (CRC) one of the most common malignancies, accounting for over 9% all cancers worldwide. To put it in perspective, 5% people will develop CRC their lifetime. Biomarkers specific to particular type can assist evaluation survival probability and help clinicians assess treatment modalities, an example being programmed death ligand-1 (PD-L1). With regards PD-L1, this first study evaluate SP-142 antibody...
Abstract Colorectal cancer (CRC) is the third most common cause of related death in United States (Jasperson et al. Gastroenterology 138:2044–2058, https://doi.org/10.1053/j.gastro.2010.01.054 , 2010). Many studies have explored prognostic factors CRC. Today, much focus has been placed on tumor microenvironment, including different immune cells and extracellular matrix (ECM). The present study aims to evaluate role V-domain immunoglobulin suppressor T cell activation (VISTA). We utilized...
Abstract African Americans face a higher rate of colorectal cancer (CRC) incidence and mortality compared to other ethnicities. Identifying key prognostic factors is essential for better outcomes in this group. This study focused on the value stromal grading tumor microenvironment (TME) American CRC patients, using both manual digital pathology. A retrospective analysis cases was conducted. Two cohorts were established: control cohort (patients without recurrence) recurrence with...
Abstract Background: Due to its high ability of metastasis, ovarian cancer remains the most lethal gynecological malignancy, yet underlying mechanism unconfirmed. Objectives : The main purpose is probe into role and regulation octamer-binding transcription factor 4 (OCT4) in angiogenesis metastasis cancer. Methods Immunohistochemistry (IHC) immunofluorescence epithelial specimens benign tumor samples were performed, followed by RNA-sequencing examination angiogenesis, cell migration invasion...
Endometrial cancer (EC) is a disease with good and poor prognostic subtypes. Dedifferentiated endometrial carcinoma (DEC), undifferentiated (UEC), clear cell (CEC) are rare high-grade tumors, associated prognosis high pathologic stage. Many studies have been performed on the programmed death-ligand 1 (PD-L1) axis mainly focus endometrioid adenocarcinomas little research has done The present body of work aims to evaluate role indoleamine-2,3-dioxygenase (IDO-1) stromal differentiation (SD),...
Abstract The nature and significance of stromal differentiation (SD), program death-ligand 1 (PD-L1), v-domain Ig suppressor T cell activation (VISTA) in gastrointestinal tumor (GIST) is largely unknown. Looking forward, the assessment SD immune check point inhibition will become more ubiquitous surgical pathology. Immature, myxoid stroma has been found to be a poor prognostic signature many cancer subtypes (colon, breast, cervix, esophagus, stomach); although little known regarding its...
Carcinosarcoma (CS) is a rare, aggressive malignancy of the Mullerian system often termed mixed malignant tumor (MMMT). It biphasic in nature, differentiating into epithelial and sarcomatous components. Tumor-node-metastasis (TNM) staging mismatch repair (MMR) status basis for both prognostication therapeutic decision making. However, stromal differentiation (SD) new frontier field histopathology many studies have demonstrated its prognostic significance. The present study first to evaluate...
Context: African Americans (AA) may carry high risk Apolipoprotein L1 ( APOL1) genetic variants that predispose them to significantly higher incidence of chronic kidney disease (CKD) and renal cell carcinoma (RCC). Objective: To study the role APOL1 alleles in patients descent with neoplasms. Design: AA nephrectomy procedure for neoplasms were retrospectively studied genotype. Non-AA neoplasm served as control group. Results: Thirty-six included. Sixteen (44%) carried no alleles; 13 (36%)...
Abstract Colorectal cancer is an overall bad player and accounts for 9% of all cancers. Today, advancements in immune checkpoint inhibition has provided therapeutics many, but not patients. This issue part due to the tumoral microenvironment; which plays a significant role determining response check point therapeutics. study serves as first evaluate potent inhibitory checkpoint: V-domain immunoglobulin suppressor T cell activation (VISTA) its CRC. was evaluated with both conventional light...