A5100593697- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Atmospheric chemistry and aerosols
- CAR-T cell therapy research
- Water Quality Monitoring and Analysis
- Trace Elements in Health
- Graphene and Nanomaterials Applications
- Sleep and related disorders
- Advancements in Battery Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Refrigeration and Air Conditioning Technologies
- Restless Legs Syndrome Research
- Cytomegalovirus and herpesvirus research
- Tryptophan and brain disorders
- Wnt/β-catenin signaling in development and cancer
- Bladder and Urothelial Cancer Treatments
- Thermal Expansion and Ionic Conductivity
- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Impact of Light on Environment and Health
- Aerodynamics and Fluid Dynamics Research
Second Military Medical University
2023-2025
Sichuan University
2024-2025
Eastern Hepatobiliary Surgery Hospital
2023-2025
First Affiliated Hospital of Zhengzhou University
2024
Yangzhou University
2024
Bozhou People's Hospital
2024
Shenyang Jianzhu University
2024
Guangdong University of Technology
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
palmitoylation, a reversible post-translational modification, is initiated by the DHHC family of palmitoyltransferases and reversed several acyl protein thioesterases. However, role mechanisms for palmitoylation in renal fibrosis have not been elucidated. Here we show DHHC9 were downregulated fibrotic kidneys mouse models chronic kidney disease (CKD) patients. Ablating tubular cells aggravated, while inducing overexpression with adeno-DHHC9 transfection or iproniazid treatment protected...
CAR T-cell therapy is well tolerated and effective in patients with Hodgkin lymphoma (HL) anaplastic large cell (ALCL). However, even second- generation anti-CD30 T-cells CD28 (28z) costimulatory domains failed to achieve the desired rate of complete responses. In present study, we developed second-generation (CD28z) third-generation (CD28BBz) targeting CD30 investigated their efficacy vitro vivo. Both CD28z CD28BBz T cells were similar regarding amplification, subsets distribution,...
Single-frame infrared small target (SIRST) detection aims to recognize targets from clutter backgrounds. Recently, convolutional neural networks have achieved significant advantages in general object detection. With the development of Transformer, scale SIRST models is constantly increasing. Due limited training samples, performance has not been improved accordingly. The quality, quantity, and diversity dataset are critical targets. To highlight this issue, we propose a negative sample...
The relationship between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) has long been extensively recognized, but their crosstalk mechanisms based on gene regulation remain elusive. In our study, for the first time, bulk RNA-seq single-cell data were used to explore shared molecular T2DM CRC. Moreover, Connectivity Map docking employed determine potential drugs targeting candidate targets. Eight genes (EVPL, TACSTD2, SOX4, ETV4, LY6E, MLXIPL, ENTPD3, UGP2) identified as...
e16209 Background: Hepatocellular carcinoma (HCC) is an aggressive liver cancer with limited treatment options, particularly in advanced stages. Surufatinib a small-molecule tyrosine kinase inhibitor that targets VEGFR-1/2/3, FGFR-1, and CSF-1R, has dual anti-angiogenesis immune-modulating effects. It may provide new option for patients HCC. Methods: This single-arm, open-label, multi-center Phase II trial (NCT05282433) evaluated monotherapy (300 mg qd, po, q3w) as third-line Eligible had...
In real-world environments, outdoor imaging systems are often affected by disturbances such as rain degradation. Especially, in nighttime driving scenes, insufficient and uneven lighting shrouds the scenes darkness, resulting degradation of both image quality visibility. Particularly, field autonomous driving, visual perception ability RGB sensors experiences a sharp decline harsh scenarios. Additionally, assistance suffer from reduced capabilities capturing discerning surrounding...
Identifying tumor-relevant T cell subsets in the peripheral blood (PB) has become a potential strategy for cancer treatment. However, subset of PB that could be used to treat remains poorly defined. Here, we found CX3CR1
There is a situation that the personnel in office building are not concentrated and scattered, some will always work at workstation, creation of local comfort unmanned workstation only cause great waste, so it necessary to create an environment with uneven distribution indoor parameters. In view this situation, we simulate two working conditions: uniform inconsistent airflow provision within space. analyze these conditions room, discuss unevenness energy efficiency ventilation openings above...
The incidence of cardiovascular disease is increasing around the world, and it one main causes death in chronic kidney diseases patients. It urgent to early identify factors cardiometabolic risk. Sleep problems have been recognized as a risk factor for both healthy people However, relationship between sleep has not clearly explored hemodialysis This study aimed investigate 3025 patients by multicenter study. After adjusting confounders, binary logistic regression models showed that reported...