A5062591939- Hepatocellular Carcinoma Treatment and Prognosis
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Advanced Glycation End Products research
- Immune cells in cancer
- Abdominal vascular conditions and treatments
- Pharmacogenetics and Drug Metabolism
- Microbial metabolism and enzyme function
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Hip and Femur Fractures
- Frailty in Older Adults
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
Second Military Medical University
2024-2025
Eastern Hepatobiliary Surgery Hospital
2024-2025
Xuzhou Medical College
2021-2024
Guangzhou University of Chinese Medicine
2024
Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide, ranking as the sixth most common and third leading cause of cancer-related mortality. Late diagnosis, limited management options, its complex etiology contribute to poor prognosis high mortality rates. Recent advances in understanding molecular mechanisms HCC innovations high-throughput sequencing technologies have led development diagnostics personalized therapies for this challenging malignancy. This review provides...
Abstract The effect from interaction of alternating current (AC) magnetic field with kilogram-level test mass (TM) limits the detectivity TianQin space-based gravitational wave (GW) detection. quantified requires determination AC susceptibility χ ( f ) TM. A torque method is proposed to measure kg-level samples at mHz band a precision 1 × 10 -7 . Combined our previous work [Phys. Rev. Appl. 18, 044010 (2022)], general frequency-dependent alloy cube side length L and electrical conductivity σ...
Abstract Background Tamoxifen treatment may induce dysregulation of estrogen homeostasis, leading to the occurrence related adverse reactions. However, potential mechanisms are still unclear. The purpose present study was uncover whether tamoxifen would act on metabolism-related biological enzymes and regulatory effect homeostasis clarify key factors reactions caused by long-term use tamoxifen. Method Female SD rats were administrated with CMC-Na solution (p.o.) once daily for four weeks...
Renal fibrosis is the main cause of development diabetic kidney disease (DKD). ACSL1 plays an important role in colon cancer and liver fibrosis. We screened by proteomics analysis then verified expression urine nephropathy patients WB ELISA. Then, a total 12 db/m db/db mice were used to verify association between renal ACSL1. Periodic acid-Schiff (PAS) staining, Masson immunostaining performed for histological studies. The relationship was studied knocking down cell experiments....
Renal fibrosis is the main cause of development diabetic kidney disease (DKD). ACSL1 plays an important role in colon cancer and liver fibrosis. We screened by proteomics analysis then verified expression urine nephropathy patients WB ELISA. Then, a total 12 db/m db/db mice were used to verify association between renal ACSL1. Periodic acid-Schiff (PAS) staining, Masson immunostaining performed for histological studies. The relationship was studied knocking down cell experiments....
Background: Breast cancer is the most prevalent in women worldwide.Notably, identification of biomarkers can help to improve efficiency early breast diagnosis and thus survival rate patients.Therefore, this study screened for such with diagnostic significance through lipidomics.Methods: Serum lipidomics analysis MMTV-PyMT mice (n = 6) their nontransgenic littermates was performed by ultrahigh-performance liquid chromatography coupled mass spectrometry (UHPLC-MS).Univariate multifactorial...
<b>Background</b> Metastasis is the most common pathway of cancer death. The lack effective predictors breast metastasis a pressing issue in clinical practice. Therefore, exploring mechanism to uncover reliable very important for treatment patients. <b>Methods </b>TMT quantitative proteomics technology was used detect protein content primary tumor tissue samples from patients with metastatic and non-metastatic at diagnosis. Assays scratch, transwell, chromatin immunoprecipitation assays,...
The primary cause of mortality in patients with ovarian cancer (OC) is tumor metastasis. A comprehensive understanding the mechanisms underlying metastasis OC essential for accurate prognosis prediction and development targeted therapeutic agents. Our findings indicate that alpha-2 Heremans Schmid glycoprotein (AHSG) downregulated exosomes. Consequently, objective this study was to identify novel prognostic markers potential targets OC.
Objective To detect serum hepcidin and erythroferrone levels in child-bearing women with iron deficiency anemia (IDA), to investigate the association between them status parameters. Methods The study consisted of 65 (35 30 age-matched healthy women). were detected by using automated chemistry analyzer, contents ferritin electrochemiluminescence immunoassay, specific enzyme-linked immunosorbent assay (ELISA) kit. quantitative variables two groups compared analyzed SPSS22.0 software. Spearman...
Abstract Background : An imbalance of oestrogen homeostasis and an inflammatory tumor microenvironment (TME) are vital risk factors for the progression metastasis breast cancer. Methods The liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantitative analysis method active substances was used to detect levels its metabolites 238 clinical serum samples, 6 malignant cancer tissues their corresponding non-tumor adjacent MMTV-PyMT mice mammary tissues. In vitro in vivo experiments were...