A5050091362- CAR-T cell therapy research
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Geomechanics and Mining Engineering
- Lymphoma Diagnosis and Treatment
- Geological and Geochemical Analysis
- Rock Mechanics and Modeling
- Geotechnical Engineering and Analysis
- earthquake and tectonic studies
- Geochemistry and Geologic Mapping
- Geotechnical Engineering and Underground Structures
- Multiple Myeloma Research and Treatments
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced battery technologies research
- Landslides and related hazards
- Supercapacitor Materials and Fabrication
- Advanced Battery Materials and Technologies
- Geological and Geophysical Studies
- Tunneling and Rock Mechanics
- Geoscience and Mining Technology
- Plant-Derived Bioactive Compounds
- Electrospun Nanofibers in Biomedical Applications
- Carbon and Quantum Dots Applications
- Chronic Lymphocytic Leukemia Research
- Biopolymer Synthesis and Applications
Wuhan University of Science and Technology
2019-2024
Southern Medical University
2024
Zhejiang Sci-Tech University
2022-2023
Wuhan Institute of Bioengineering
2019-2022
China University of Mining and Technology
2020-2022
Mineral Resources
2022
Shandong Geological Sciences Institute
2020-2021
Northwest A&F University
2021
Ministry of Natural Resources
2020
To explore the failure mechanism of roadway in layered soft rocks, a physical model with physically finite elemental slab assemblage (PFESA) method was established. Infrared thermography and video camera were employed to capture thermal responses deformation. The results showed that suffered from large A three-dimensional distinct element code (3DEC) tetrahedral blocks built characteristics deformation, stress, cracks. two patterns, layer bending fracture slipping after excavation. occurred...
Abstract TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-Hodgkin lymphoma (r/r B-NHL). From September 2016 to 2020, 257 r/r B-NHL patients were assessed for eligibility two trials our center, assessing anti-CD19 and anti-CD22 chimeric antigen receptor (CAR19/22) T-cell cocktail treatment alone or combination with autologous stem cell transplantation (ASCT). alterations screened 123 enrolled confirmed 60. CAR19/22 administration resulted best...
High-dose chemotherapy followed by autologous stem cell transplantation (HDT-ASCT) is the standard of care for chemosensitive relapsed or refractory (R/R) aggressive B lymphoma. Patients with a positive positron emission tomography (PET) scan before ASCT have poor prognosis, and those who fail to achieve therapeutic response better than partial remission after salvage treatment are ineligible candidates ASCT. We conducted this open-label single-arm prospective clinical study evaluate safety...
CAR T-cell therapy is well tolerated and effective in patients with Hodgkin lymphoma (HL) anaplastic large cell (ALCL). However, even second- generation anti-CD30 T-cells CD28 (28z) costimulatory domains failed to achieve the desired rate of complete responses. In present study, we developed second-generation (CD28z) third-generation (CD28BBz) targeting CD30 investigated their efficacy vitro vivo. Both CD28z CD28BBz T cells were similar regarding amplification, subsets distribution,...
To date, the general and catalytic α-arylation of cyclic 1,3-dicarbonyls remains elusive. We now report first Rh-catalyzed with benzocyclobutenols through a iodonium ylide strategy. Our strategy represents good solution for previously challenging sterically demanding aryl partners, which is especially appropriate structurally unique heteroaromatic 1,3-dicarbonyls. approach features mild conditions, readily available starting materials, high yields, excellent functional group-tolerance,...
Long-term outcome is unfavourable for relapsed/refractory (r/r) lymphoma patients who are resistant to salvage chemotherapy, even after subsequent autologous stem-cell transplantation (ASCT). Although anti-CD30 chimeric antigen receptor (CAR30) T-cell therapy induces high response rates in these patients, the duration of relatively limited. This open-label, single-center and single-arm pilot study investigated safety efficacy ASCT tandem with CAR30 infusion r/r CD30+ lymphoma. The primary...
Patients with Burkitt lymphoma who are refractory to initial therapy or relapse after undergoing intensive chemotherapy and autologous stem cell transplantation (ASCT) usually have a poor prognosis. While there has been considerable progress in the use of chimeric antigen receptor-modified (CAR) T immunotherapy for treatment relapsed (r/r) malignancies, explicit data on adult patients r/r limited. We conducted two single-arm clinical trials evaluate efficacy toxicity CD19/CD22 CAR both alone...
The northwestern part of the Jiaodong Peninsular is most important gold producer in China. Recently, discovery mineralization at a depth 3,000 m below surface region has generated great interest for profound prospecting potential among explorers. However, maximum exploration and different goldfields have yet to be clarified. This work presents two low-temperature thermochronological datasets zircon/apatite (U-Th)/He (ZHe/AHe) data ∼ 2,000-m-deep vertical boreholes from Jiaojia Linglong an...
Despite impressive progress, a significant portion of patients still experience primary or secondary resistance to chimeric antigen receptor (CAR) T-cell immunotherapy for relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). The mechanism involves extrinsic and intrinsic dysfunction. In the present study, total 135 DLBCL treated with murine CD19/CD22 cocktail CAR T-therapy were assessed retrospectively. Based on four criteria (maximal expansion transgene/CAR-positive levels...