A5065693501- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Aortic Disease and Treatment Approaches
- Heavy metals in environment
- Gout, Hyperuricemia, Uric Acid
- Air Quality and Health Impacts
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Total Knee Arthroplasty Outcomes
- Head and Neck Cancer Studies
- Aortic aneurysm repair treatments
- Lipid metabolism and disorders
- Cardiovascular Health and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Alzheimer's disease research and treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Folate and B Vitamins Research
- Nutritional Studies and Diet
Sichuan University
2025
Southwest Jiaotong University
2025
West China Medical Center of Sichuan University
2025
Viva Biotech (China)
2025
Hefei First People's Hospital
2022-2024
Shaoxing University
2024
Lanzhou University
2014-2024
Shaoxing People's Hospital
2024
Minhang District Central Hospital
2024
Fudan University
2019-2024
Aquaporin-4 (AQP4) is the predominant water channel in brain and selectively expressed astrocytes. Astrocytic endfoot membranes exhibit tenfold higher densities of AQP4 than non-endfoot membranes, making an excellent marker astrocyte polarization. Loss polarization known to compromise astrocytic function be associated with impaired K+ homeostasis. Here we investigate by a combination light electron microscopic immunocytochemistry whether amyloid deposition loss polarization, using as marker....
Although pathologic changes to the structure and function of small blood vessels are hallmarks various cardiovascular diseases, limitations conventional investigation methods (i.e. pressure myography) have prohibited a comprehensive understanding underlying mechanisms. We developed microfluidic device facilitate assessment resistance artery under physiological conditions (37 °C, 45 mmHg transmural pressure). The platform allows for on-chip fixation, long-term culture fully automated...
Although previous studies have examined the hepatotoxicity of single metal exposure, associations between mixture and non-alcoholic fatty liver disease (NAFLD) or fibrosis remain unclear. This study investigated urinary with risks NAFLD in US adults using data from National Health Nutrition Examination Survey (NHANES) 2017.01 to 2020.03. Vibration-controlled transient elastography was used detect controlled attenuation parameter (CAP) stiffness measurement (LSM), which are indicators...
Establishing reliable early warning models for severe dengue cases is a high priority to facilitate triage in dengue-endemic areas and optimal use of limited resources. However, few studies have identified the complex interactive relationship between potential risk factors dengue. This research aimed assess detect their high-order combinative effects on A structured questionnaire was used collect detailed outbreak data from eight representative hospitals Dhaka, Bangladesh, 2019. Logistic...
To assess the prevalence of diabetic peripheral neuropathy (DPN) and its risk factors in type 2 diabetes mellitus (T2DM) population.This cross-sectional study enroled patients with T2DM between July December 2017 from 24 provinces China. Diabetic severity were assessed by Toronto clinical scoring system, symptoms score (NSS) disability score. The DPN analysed.A total 14,908 enroled. was 67.6%. Among 10,084 DPN, 4808 (47.7%), 3325 (33.0%), 1951 (19.3%) had mild, moderate, severe respectively....
Policy guidance plays a critical role in urban expansion and development patterns, the scientific prediction of land use change trends assessment ecological benefits future are essential for effective policy-making. Different policies not only shape evolution spatial patterns but also have profound impact on heat island effect (UHI) cooling benefits. This study explores changes Tianfu New District UHI conducts multi-scenario simulations combined with different policy contexts. Focusing...
Background Limited response to programmed death ligand-1 (PD-L1)/programmed 1 (PD-1) immunotherapy is a major hindrance of checkpoint in non-small cell lung cancer (NSCLC). The abundance PD-L1 on the tumor surface crucial for responsiveness PD-1/PD-L1 immunotherapy. However, negative control expression and physiological significance inhibition NSCLC remain obscure. Methods Bioinformatics analysis was performed profile investigate long non-coding RNAs that negatively correlated with...
Background and Purpose— We sought to demonstrate that tumor necrosis factor (TNF)-α, via sphingosine-1-phosphate signaling, has the potential alter cochlear blood flow thus, cause ischemic hearing loss. Methods— performed intravital fluorescence microscopy measure capillary diameter in anesthetized guinea pigs. To ex vivo, beds from gerbil spiral ligament were isolated lateral wall maintained an organ bath. Isolated modiolar arteries, transfected culture, used calcium sensitivity...
Background— Heart failure is associated with neurological deficits, including cognitive dysfunction. However, the molecular mechanisms underlying reduced cerebral blood flow in early stages of heart failure, particularly when pressure minimally affected, are not known. Methods and Results— Using a myocardial infarction model mice, we demonstrate tumor necrosis factor-α (TNFα)–dependent enhancement posterior artery tone that reduces before any overt changes brain structure function. TNFα...
Ambient particulate matters and temperature were reported to have additive effects over the respiratory disease hospital admissions deaths. The purpose of this study is discuss interactive pulmonary toxicities cold stress fine matter (PM2.5) exposure by estimating inflammation oxidative responses. 48 Wistar male rats, matched weight age, randomly assigned six groups, which treated with alone (0 °C, 10 20 °C (Normal control)) stresses plus PM2.5 exposures respectively. Cold groups...
The appropriate administration regimen of polymyxin B is yet controversial. present study aimed to explore the optimal dose under therapeutic drug monitoring (TDM) guidance.In China's Henan province, 26 hospitals participated in a randomized controlled trial. We included patients with sepsis caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) susceptible B. were randomly divided into high-dose (HD) group or low-dose (LD) and received 150 mg loading dose, 75 every 12 h 100 50 h,...
Abstract Acute lymphoblastic leukemia (ALL) is a heterogeneous clonal disease originated from B- or T-cell lymphoid precursor cells. ALL often refractory relapses after treatment. Novel treatments are anxiously needed in order to achieve better response and prolonged overall survival patients. In the present study, we aimed at examining antitumor effect of niclosamide on ALL. We investigated effects proliferation apoptosis vitro, growth cells xenografted NOD-Prkdcem26Cd52 il2rgem26Cd22 /Nju...
Amyloid-β deposition in senile plaques is one of the main pathological changes Alzheimer’s disease (AD). We previously reported that aquaporin-4 (AQP4) redistributed within astrocytes cerebral amyloid angiopathy tg-ArcSwe mouse model AD, suggesting AQP4 may participate amyloid-β deposition. However, role plaque formation not currently clear. The objective current study was to explore distribution mice more depth by combined application immunofluorescence cytochemistry and immunogold electron...
The efficacy and safety of intrawound vancomycin for preventing surgical site infection in primary hip knee arthroplasty is uncertain.A systematic review the literature was conducted, indexed from inception to March 2020 PubMed, Web Science, Cochrane Library, Embase, Google Scholar databases. All studies evaluating and/or patients who underwent were included. Incidence periprosthetic joint (PJI), superficial infection, aseptic wound complications, acute kidney injury, anaphylactic reaction,...