A5113001311- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- RNA modifications and cancer
- Diabetic Foot Ulcer Assessment and Management
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Muscle Physiology and Disorders
- Eating Disorders and Behaviors
- Cell death mechanisms and regulation
- Apelin-related biomedical research
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Reproductive Biology and Fertility
- Cancer, Stress, Anesthesia, and Immune Response
- Vascular Tumors and Angiosarcomas
- Animal Genetics and Reproduction
- Renal and Vascular Pathologies
- Health and Lifestyle Studies
- Cancer, Hypoxia, and Metabolism
- Retinal Diseases and Treatments
- Diet and metabolism studies
Nanjing Drum Tower Hospital
2013-2025
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2023-2024
Guangdong Provincial People's Hospital
2024
Lanzhou University
2022-2024
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems
2024
Institute of Grassland Research
2024
Shantou University Medical College
2024
South China University of Technology
2024
Shantou University
2024
To assess the prevalence of diabetic peripheral neuropathy (DPN) and its risk factors in type 2 diabetes mellitus (T2DM) population.This cross-sectional study enroled patients with T2DM between July December 2017 from 24 provinces China. Diabetic severity were assessed by Toronto clinical scoring system, symptoms score (NSS) disability score. The DPN analysed.A total 14,908 enroled. was 67.6%. Among 10,084 DPN, 4808 (47.7%), 3325 (33.0%), 1951 (19.3%) had mild, moderate, severe respectively....
The Small Tailed Han sheep and Hu are two prolific local in China. In this study, the polymorphisms of BMPR-IB (Bone morphogenetic protein receptor IB), BMP-15 15) FSHR (follicle stimulating hormone receptor) were investigated to check whether they associated with litter size sheep. Consequently, three polymorphisms, FecB mutation (c.746A>G), FecG (c.718C>T) (g. 47C>T) found above breeds a total number 1630 individuals. single marker association analysis showed that mutations...
Although diabetic glomerulopathy is a characteristic of kidney disease (DKD), manifesting as thickened glomerular basement membrane, mesangial expansion with increased matrix, capillary microaneurysms, hypocellular nodules, and even glomerulosclerosis, accumulating data has shown that tubulopathy (DT) exists from the beginning hyperglycemia throughout duration mellitus (DM), playing pivotal role in pathogenesis DKD. Under hyperglycemic conditions, proximal tubular epithelium cells (PTECs)...
The aim of this study was to investigate the relationship between AST/ALT ratio and osteopenia or osteoporosis in patients with type 2 diabetes mellitus (T2DM). A total 589 T2DM were divided into two groups based on T-score: T-score ≥ -1.0 group, normal bone mineral density < (OP). association osteopenia/OP evaluated by multivariate analyses. receiver operating characteristic (ROC) curves used estimate diagnostic performance according area under ROC curve (AUC). group showed significantly...
This study explored the correlation between clinical explorations, including modified Mallampati score and Müller's maneuver, with drug-induced sleep endoscopy (DISE) findings regarding retrolingual obstruction.One hundred forty-two obstructive apnea patients were enrolled in this prospective study. All of received explorations scoring maneuver clinic. Drug-induced was further evaluated operating room.A significant relationship noted obstruction during DISE. In contrast, no DISE...
Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic sheep lacking. Here, we generated 92 transcriptomic and epigenomic data sets from nine major tissues, along with whole-genome 2357 individuals across 29 breeds worldwide, 4006 phenotypic related tail fat weight. We constructed first multi-tissue epigenome atlas terms elements, chromatin states, their functions explored utility elements interpreting...
Scope It has been demonstrated that a mutation of MTHFR C677T increases plasma total homocysteine (Hcy) concentration and decreases folate. Natural foods can improve Hcy levels, but the effect certain remains undetermined. The aim this study was to investigate association between food groups Hcy, explore correlations dietary folate/vitamin (Vit) B12 for genotype‐specific population. Methods results A 4507 adults were enrolled in study, all whom underwent physical examinations genotyping....
Herein we detected single nucleotide polymorphisms in MEF2B and UCP3 by DNA sequencing the KASPar technology analyzed their association with sheep growth traits. Two synonymous mutations, g.1826 C > T g.10266 G C, were detected, respectively, they found to be significantly associated traits (p < 0.05). In case of T, average body weight chest cannon circumference CC genotype higher than those CT TT genotypes Moreover, GG GC CC/GG was compared other combinations. We also assessed expression...
We report here the complete genome sequence of a GII.6 norovirus strain detected in clinical fecal specimen from United States. The virus has length 7,547 bp and GC content 50.1%. Complete genotyping full-genome identified genotype as GII.P6_GII.6.
To investigate whether peripheral neuropathy scale scores are associated with myocardial infarction (MI) in patients type 2 diabetes mellitus (T2DM).In this cross-sectional study, 32,463 T2DM were enroled from 103 tertiary hospitals 25 Chinese provinces. Based on a history of MI, participants divided into the MI group (n = 4170) and non-MI 28,293). All assessed using four scales, namely, Neurological Symptom Score (NSS), Disability (NDS), Toronto Clinical Scoring System (TCSS), Michigan...
Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumour. Due to its low incidence, standard treatment regimen for PEComa has not yet been established. Radiotherapy synergistic effect with PD-1 inhibitors and GM-CSF. We treated advanced malignant triple of inhibitor, SBRT GM-CSF provide better therapeutic effect.A 63-year-old woman was diagnosed after presenting postmenopausal vaginal bleeding. Despite two surgeries, the eventually metastasized throughout body. formulated...
To investigate and compare the chemical features antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, AAP-C) were prepared by mannanase, β-dextranase, cellulase. Their determined using high-performance liquid chromatography infrared spectroscopy. The properties performed both in vitro vivo. Results showed that surface morphology A. cell wall treated with enzymes was slightly under scanning electron microscopy. extraction yields AAP-M,...
To investigate the molecular mechanism of osteoporosis caused by ketogenic diet (KD) using transcriptomic analysis.Sixteen 8-week-old female C57BL/6J mice were divided into KD group and sham for feeding with normal 3 months, respectively. Body weight, blood glucose ketone levels measured every two weeks. Microstructure cancellous bone in distal femur was observed Micro-CT. Total RNA extracted from marrow cells analysis bioinformatics analysis. RT-qPCR used to verify expression genes...
The clinical characteristics and outcomes of small fiber neuropathy (SFN) in Chinese patients with type 2 diabetes mellitus (T2DM) have not been thoroughly described. In this study, we investigated the metabolic neurological indexes prognosis T2DM based on skin biopsy. A total 34 healthy volunteers were recruited for biopsy to establish reference range intra-epidermal nerve density (IENFD), 89 attending Nanjing Drum Tower Hospital evaluated at baseline. Of these patients, 17 pure SFN nine...
Obesity is a chronic metabolic disease which relevant to various factors. strong risk factor of many cardiovascular and diseases will bring burdens the life overweight obese people. Research showed that most obesity were caused by unhealthy lifestyle. Therefore, comprehensive lifestyle intervention based on physical activity, diet psychology crucial in management This study reviewed current situation strategies, means interventions possible interaction between those interventions. The...
Objective To investigate the relationship between polymorphisms of angiotensin Ⅱ receptor gene and risk primary aldosteronism (PA). Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine 1166A/C AT1R 1675A/G AT2R in 85 patients with PA 100 healthy controls. Results There no significant difference genotypes (AA, AC, CC) allele (A C) frequency among controls (χ2=0.430, P=0.806).There obvious AG, GG) G) two groups (χ2=6.121,...
Objective To investigate the effects of glucagon-like peptide-1 (GLP-1) receptor agonist on function and differentiation brown adipocytes in mice.Methods Primary mice were cultivated vitro.Before induction,brown assigned to four groups:GLP-1 10-8mol/L group,GLP-1 10-9mol/L group,L-NAME 10-3 mol/L group,and control group.Finally,adipocytes put under morphological observation.The expression levels genes different groups detected by RT-PCR.The single factor analysis was used for data...
<p>Supplementary figure S2. Kaplan-Meier analysis of OS and RFS for (A) NLR (B) PLR in the training cohort; Predictive ability SII was compared with other clinical parameters AUCs 95% CI TTR (C) validation cohorts (D) are shown. (*, P<0.05 versus SII).</p>
<p>Supplementary figure S1. The optimal cutoff value for the SII was selected by X-tile 3.6.1 software (Yale University, New Haven, CT, USA).</p>
Abstract BackgroundThe clinical characteristics and outcomes of small fibre neuropathy (SFN) in Chinese patients with type 2 diabetes have not been thoroughly described, we investigated metabolic neurological indexes the prognosis diabetic based on skin biopsy. MethodsThirty-four healthy volunteers were recruited for biopsy to establish reference range intraepidermal nerve density (IENFD). Eighty-nine from Department Endocrinology at Nanjing Drum Tower Hospital between December 2015 April...