A5088477543- Genetics and Neurodevelopmental Disorders
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Biochemical and Molecular Research
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Lung Cancer Diagnosis and Treatment
- Neural dynamics and brain function
- Traffic Prediction and Management Techniques
- Mental Health Research Topics
- Genomics and Rare Diseases
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Humor Studies and Applications
- Dam Engineering and Safety
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Image and Object Detection Techniques
- Dysphagia Assessment and Management
- Neural Networks and Reservoir Computing
- Signaling Pathways in Disease
- Water Quality and Pollution Assessment
- Maritime Navigation and Safety
- E-commerce and Technology Innovations
- Additive Manufacturing and 3D Printing Technologies
- Research studies in Vietnam
- Video Surveillance and Tracking Methods
Hunan Provincial Maternal and Child Health Hospital
2022-2025
Central South University
2022-2025
University of Electronic Science and Technology of China
2025
Mianyang Central Hospital
2025
University of South China
2025
Shaanxi Provincial People's Hospital
2022-2024
Shanxi Medical University
2022-2024
Jilin University of Finance and Economics
2024
Changchun University
2024
Institute of Botany
2023
The CHOICE-01 study investigated the efficacy and safety of toripalimab in combination with chemotherapy as a first-line treatment for advanced non-small-cell lung cancer (NSCLC).Patients (N = 465) treatment-naive, NSCLC without EGFR/ALK mutations were randomly assigned 2:1 to receive 240 mg (n 309) or placebo 156) once every 3 weeks 4-6 cycles, followed by maintenance plus standard care. Stratification factors included programmed death ligand-1 expression status, histology, smoking status....
Stress granules (SGs) are cytoplasmic assemblies in response to a variety of stressors. We report new neurodevelopmental disorder (NDD) with common features language problems, intellectual disability, and behavioral issues caused by de novo likely gene-disruptive variants UBAP2L , which encodes an essential regulator SG assembly. Ubap2l haploinsufficiency mouse led social cognitive impairments accompanied disrupted neurogenesis reduced formation during early brain development. On the basis...
ABSTRACT Neurodevelopmental disorders (NDDs) encompass a group of conditions that impact brain development and function, exhibiting significant genetic clinical heterogeneity. NAA15, the auxiliary subunit N‐terminal acetyltransferase complex, has garnered attention due to its association with NDDs. However, precise role NAA15 in cortical contribution NDDs remain elusive. By employing targeted sequencing on large Chinese cohort affected by ASD conducting an extensive literature review, we...
Abstract The COX4I1 is responsible for encoding a crucial component of cytochrome c oxidase, integral to electron transport in the mitochondrial respiratory chain. Mutations can result rare autosomal recessive disorder characterized by growth retardation, slow weight gain, microcephaly, and potentially, hematologic symptoms such as Fanconi anemia or neurological impairments including developmental regression severe epilepsy. In this study, we report first case deficiency China, identified...
Oropharyngeal dysphagia (OD) is an emergent health concern in older adults, with incidence rates escalating due to age-related and various neurological physical conditions. This study identifies risk protective factors for new-onset OD, emphasis on gender differences. Utilizing data from the National Health Aging Trends Study (NHATS), this analyzed 6,360 participants (58.1% women) across 2011-2014 2015-2018 periods. Employing a random forest feature selection, specifically recursive...
1 中国科学院植物研究所植被与环境变化国家重点实验室, 北京 100093; 2 中国科学院大学, 100049; 3 河北农业大学资源与环境科学学院, 河北 省农田生态环境重点实验室, 河北保定 071000; 4 福建师范大学地理科学学院, 福州 350117 摘 要 理解草地生态系统结构和功能对氮富集的响应及其机制有助于准确评估大气氮沉降等外源氮输入的生态效应。全球 范围内建立的多水平氮添加实验为认识草地生态系统结构和功能对氮输入的非线性响应机制提供了有效途径。 为了反映学术 界基于多水平氮添加控制实验取得的主要研究进展, 该文综述了草地群落多样性和生态系统碳氮循环过程对外源氮输入的 非线性响应特征及其驱动机制。按照目前的研究, 氮输入会导致草地植物物种多样性、功能多样性以及土壤细菌多样性下降, 但真菌多样性的变化并不明显。地上和地下生产力对氮输入的响应趋势存在差异: 地上生产力沿氮添加梯度呈"先上升后饱 和"的变化规律, 而根系生产量和根冠比呈下降趋势
Familiar chunks can be processed highly efficiently, and this automatic process prohibit the problem solver from developing novel original ways to creatively solve difficult problems. For reason, role of reverse process, chunk decomposition (CD)-the by which familiar patterns are broken down into their component elements in order regrouped another meaningful manner-has been generally recognized as part creative process. However, previous studies on issue have mainly focused CD (the...
Unlike the strategy of cognitive regulation that relies heavily on top-down control function prefrontal cortex (PFC), which was recently found may be critically impaired in stressful situations, traditional Chinese philosophy and medicine views different types emotionality as having mutual promotion counteraction (MPMC) relationships, implying a novel approach requires less cognition to emotional regulation. Actually, our previous studies have indicated anger responses could successfully...
Chunk decomposition refers to decompose familiar patterns into their component elements so that they can be regrouped in a meaningful manner. It is creative process lead insight. According the Representation Change Theory, chunk help problem solvers update interpretation of situation and then restructure starting states problem′s representation. The concept was put forward by theoretical psychologist Ohlsson S. 1980s. Since then, studies about cognitive neural mechanisms have been going on...
Black odorous water seriously endangers urban ecological functions. The "Water Pollution Prevention Action Plan" promulgated by the State Council has attached great importance to this issue and set a timetable for achieving goal of pollution remediation black problem. However, in process managing city's water, we found that apparent governance effect is not sustainable. Many waters have been treated become clear returned state. This problem constrained completion control plan, urgently needs...
In deep-sea exploration projects, submarines have become one of the recreational activities for people and also serve as primary means scientific investigation in deep ocean. To monitor submarine's position status real-time, we developed dynamic Monte Carlo random walk models to predict its location over some time. Due complexity underwater environment, search rescue equipment is necessary locate submarine case malfunction or loss contact. Therefore, employ VIKOR evaluation ranking model...
Plain Language SummaryWhat is this summary about?This describes early (not final) results of a clinical study called CHOICE-01. The looked at the effect medicine toripalimab when added to standard chemotherapy (chemicals used stop growth or kill cancer cells) for adults with untreated non-small cell lung (NSCLC) without driver mutations (i.e. EGFR/ALK excluded from study) that was classified as locally advanced had spread other parts body (metastatic NSCLC). Researchers wanted see whether...
<title>Abstract</title> Biallelic mutations in <italic>SHMT2</italic> cause neurodevelopmental disorders with cardiomyopathy, spasticity, and brain abnormalities (NEDCASB; OMIM: 619121). This recently described metabolic disorder are characterized by severe intellectual disability, microcephaly, spastic paraplegia, peripheral neuropathy, corpus callosum dysgenesis, facial limb deformities, progressive hypertrophic cardiomyopathy. Herein we describe the clinical characteristics of a patient...
In order to study the rapid and efficient identified method of accident-prone section in montane highway, principal component - gray clustering analysis has been proposed. By deep characteristics section, indexes have screened out, reducing dimensionality incomplete information processing organically integrated, weight coefficients are creatively determined based on content. Based data investigation treatment, using components analysis, security level sections is achieved by programming. The...
This paper introduced the stepwise regression analysis principle, grey correlation and Kalman filter. Aiming at situation of more impact factors on a certain dam deformation, new algorithm for filter based is given. It takes horizontal deformation example, through to discuss degree various establish model, carry out comparison model. The results show that both two kinds models have better precision, but relational presents higher synthesis accuracy can provide accurate prediction results.
In order to prevent the phenomenon that lorries take some illegal operations, such as jumping and taking s-shaped line so reduce vehicle weight when they are passing highway toll station, also in curtail fees disputes meantime, this article studied algorithm which can detect beating trajectory automatically. Firstly, license plates located by HSI color space texture features. Secondly, it achieved position of more exactly with K-means clustering. Furthermore, plate centroid was calculated...
Combining with the localized analysis capability of wavelet and learning neural network, this article investigates network nonlinear time series model architecture integrated which combines affine transformation rotation ,moreover, based on algorithm that substitutes Morlet function for Sigmoid function, researchers analyze application Wavelet Neural Network in settlement deformation high-speed rail. The example paper discussed shows has good results prediction, especially large complicated...