A5102825695- Epigenetics and DNA Methylation
- Kidney Stones and Urolithiasis Treatments
- Heavy metals in environment
- Cardiovascular Health and Risk Factors
- Genetics and Neurodevelopmental Disorders
- Marine Biology and Environmental Chemistry
- Urinary Bladder and Prostate Research
- Bacillus and Francisella bacterial research
- Glioma Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Polymer Surface Interaction Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Hormonal Regulation and Hypertension
- Kruppel-like factors research
- Brain Tumor Detection and Classification
- Advanced biosensing and bioanalysis techniques
- Coronary Artery Anomalies
- Estrogen and related hormone effects
- Cancer-related gene regulation
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Muscle and Compartmental Disorders
- Environmental Toxicology and Ecotoxicology
University of Maryland, Baltimore County
2023-2025
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
National Clinical Research Center for Digestive Diseases
2024
Affiliated Hospital of North Sichuan Medical College
2021-2023
North Sichuan Medical University
2023
University of Maryland, Baltimore
2023
Dalian Ocean University
2019-2022
Sichuan University
2005-2022
West China Hospital of Sichuan University
2022
Amyloid beta protein (Abeta) is the principal component of neuritic plaques in Alzheimer's disease (AD). Abeta derived from amyloid precursor (APP) by beta- and gamma-secretases. Beta-site APP cleaving enzyme 1 (BACE1) has been identified as major beta-secretase. BACE2 homolog BACE1. The gene on chromosome 21 implicated pathogenesis AD. However, function generation controversial. Some studies have shown that cleaved at beta-site whereas other showed it around alpha-secretase site. To...
Abstract Constructing antifouling coatings for biosensing interfaces is a major hurdle in driving their practical application. Inspired by the excellent properties of natural cell membranes, conductive biomimetic interface coating proposed, which highly mimics biofilms while overcoming low conductivity defects conventional coatings. Polyethylene glycol–Au gel selected as support structure and electron transfer layer, on phospholipids ampholytes are applied to construct hydration layer...
Stress granules (SGs) are cytoplasmic assemblies in response to a variety of stressors. We report new neurodevelopmental disorder (NDD) with common features language problems, intellectual disability, and behavioral issues caused by de novo likely gene-disruptive variants UBAP2L , which encodes an essential regulator SG assembly. Ubap2l haploinsufficiency mouse led social cognitive impairments accompanied disrupted neurogenesis reduced formation during early brain development. On the basis...
For children with a history of Kawasaki disease (KD), low grade inflammation was generally reported to be associated persistent coronary artery lesions (CAL). However, this association has not been clearly demonstrated hold true in KD adolescents and young adults (10-25 years age).We enrolled 104 subjects into our study, who were separated the following 3 groups controls: 1): 22 patients angiography-confirmed CAL which persisted for an average 12.5 after onset KD; 2) 38 regressed aneurysms;...
Hydroxysteroid dehydrogenases (HSDs) play an important role in the metabolism of steroids and xenobiotics. However, function HSDs invertebrates is unclear. In this study, we cloned hydroxysteroid dehydrogenase-like 2 (HSDL2) gene Perinereis aibuhitensis, which 1652 bp length, encoding 400 amino acids. This sequence contains conserved short-chain dehydrogenase sterol carrier protein-2 domain, alignment analysis showed its close relationship with other invertebrate HSDL2. Further, tissue...
G-protein-coupled receptors (GPCRs) are one of the most important molecules that transfer signals across plasma membrane, and play central roles in physiological systems. The molecular architecture GPCRs allows them to bind diverse chemicals, including environmental contaminants.To investigate effects benzo(a)pyrene (B(a)P) on GPCR signaling, protein kinase A (PKA) catalytic subunit Perinereis aibuhitensis were cloned. expression patterns these two genes during B(a)P exposure determined with...
BackgroundThe prognostic significance of tumor size with adrenocortical carcinoma (ACC) patients has not yet been thoroughly evaluated. Our objective was to investigate the influence on value in adult ACC patients.MethodsThe Surveillance, Epidemiology and End Results Program (SEER) employed identify who had diagnosed from 2004 2015. The "X-Tile" program determined optimal cutoff size. Cancer-specific survival (CSS) overall survive (OS) were estimated. outcomes risk factors analyzed by...
ObjectiveThe National Biosurveillance Integration Center (NBIC) isdeveloping a scalable, flexible open source data collection, analysis,and dissemination tool to support biosurveillance operations bythe U.S. Department of Homeland Security (DHS) and its federalinteragency partners.IntroductionThe NBIC integrates, analyzes, distributes key informationabout health disease events help ensure the nation’s responsesare well-informed, save lives, minimize economic impact. NBICserves as bridge...
Abstract Background: The incidence of Isocitrate dehydrogenase (IDH) gene mutation had closed contact with the development and prognosis WHO grade II/III glioma. This study aims to establish evaluate predicting random Forest model for IDH1 based on parenchyma peritumoral edema ADC image texture parameters Materials Methods: 146 patients (77 males 69 females) histologically confirmed anaplastic glioma were divided into training validation groups in a ratio 7:3 according requirements Random...