A5101702053- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Neonatal Health and Biochemistry
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Amino Acid Enzymes and Metabolism
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- 3D Printing in Biomedical Research
- FOXO transcription factor regulation
- Genetic Associations and Epidemiology
- Effects and risks of endocrine disrupting chemicals
- Ginseng Biological Effects and Applications
- Biopolymer Synthesis and Applications
- Glutathione Transferases and Polymorphisms
- Natural Antidiabetic Agents Studies
- Antimicrobial Peptides and Activities
- Brain Metastases and Treatment
Jinzhou Medical University
2007-2025
First Affiliated Hospital of Liaoning Medical University
2013-2017
Creative Research Enterprises (United States)
2016
Dalian Medical University
2016
First Affiliated Hospital of Dalian Medical University
2016
Dalian Institute of Chemical Physics
2016
Transforming growth factor-β1 (TGF-β1), secreted by main components of tumor microenvironment, is considered to be closely associated with cancer development and chemoresistance. The present study aimed analyze the effects mechanisms underlying TGF-β1-induced chemoresistance oxaliplatin (LOH) in human colorectal (CRC) cell lines. cytotoxic LOH subsequent TGF-β1 treatment were assessed three CRC lines MTT assay. In addition, epithelial mesenchymal transition (EMT), DNA damage apoptosis assays...
Patients with gastric ulcer (GU) have a significantly higher risk of developing cancer (GC), especially within 2 years after diagnosis. The main way to improve the prognosis GC is predict tumorigenesis and metastasis in early stage. objective this study was demonstrate ability human plasma amino acid metabolic profile for discriminating GU. In study, we first used liquid chromatography-tandem mass spectrometry technique characterize metabolism GU patients. Plasma samples were collected from...
This study aims to explore the effects of microRNA-21 (miR-21) on radiosensitivity in non-small cell lung cancer (NSCLC) by targeting programmed deanth 4 (PDCD4) and regulating PI3K/AKT/mTOR signaling pathway. Cancer tissues adjacent normal were collected from 97 NSCLC patients who received a standard radiotherapy regimen. TUNEL assay was applied determine apoptosis tissues. The qRT-PCR used detect expressions miR-21 expression PDCD4 mRNA. protein pathway-related proteins determined Western...
Background:
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) are indispensable for human health. Notably, imbalanced levels of maternal PUFAs during pregnancy can exert lasting impacts on the developing fetus. There is an urgent need a robust rapid method that simultaneously quantify multiple n-3 n-6 in plasma adapt to large-scale clinical screening. Sample preparative process consisted non-derivatized alkali hydrolyzing liquid-liquid extraction followed by reconstituting after being...
Background Research has indicated that both total cholesterol (TC) and low-density lipoprotein (LDL) levels may impact the risk of colorectal cancer (CRC). However, as TC LDL consist multiple lipid species, it remains uncertain which specific species contribute to this risk. Therefore, study plans search for major influence CRC. Methods Initially, a two-sample Mendelian randomization analyses was employed examine association between 179 Subsequent this, meta-analysis conducted on results in...
AIM:To investigate the targeted inhibition of proliferation and migration SW620 human colon cancer cells by upregulating miRNA-145 (miR-145). METHODS:Forty-five samples tissues 45 normal control were obtained from biological database First Affiliated Hospital Liaoning Medical University.We performed quantitative analysis miR-145 N-ras expression in tissues; reverse transcriptase polymerase chain reaction colonic epithelial cells; construction lentiviral vector determination transduced with...
Summary Breast cancer (BC) is the most commonly diagnosed in women worldwide. Arginine a semiessential amino acid humans and essential for several biological pathways malignant normal cells, such as ornithine N1, N12‐diacetylspermine (DiAcSpm). This study aimed to determine role of arginine these downstream molecules BC. Plasma arginine, ornithine, arginine–to–ornithine ratio (AOR) were analysed by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Urine samples measured colloid gold...
To investigate the correlation between miR-26b and non-small-cell lung cancer (NSCLC).NSCLC tissues normal that were more than 7 cm adjacent from tumor collected 154 NSCLC patients. Additionally, 63 specimens benign disease selected as control group. Real-time fluorescent quantitative PCR was used to detect expression in tissues.miR-26b significantly lower other two types of tissues. Receiver operating characteristic curve analysis showed area under 0.856 with sensitivity specificity 79.9...
Gastric cancer cells are resistant to tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and the resistance mechanism is not fully understood. In human gastric MGC803 BGC823 cells, TRAIL induces insulin‐like growth factor‐1 receptor (IGF‐1R) pathway activation. Treatment with IGF‐1R inhibitor OSI‐906 or small interfering RNAs against IGF‐1R, prevents activation increases TRAIL‐induced apoptosis. The promoted by translocation into lipid rafts. Moreover, of rafts regulated Casitas...
Scutellarin is an important bioactive flavonoid extracted from Erigeron breviscapus (Vant.) Hand‐Mazz, and scutellarein the corresponding aglycone of scutellarin. The present study aims to compare inhibition potential scutellarin towards several UDP‐glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 UGT2B7. It was demonstrated that exerted stronger tested UGT isoforms than Furthermore, kinetic type parameters (K i ) were determined for scutellarein's these isoforms....
The present study sought to explore the role of microRNA-330 (miR-330) in predicting radiation response and prognosis patients with brain metastasis (BM) from lung cancer (LC).Patients BM LC were identified classified into radiation-sensitive radiation-resistant groups according overall survival rate, local distant recurrence rate after conventional whole-brain therapy. Quantitative realtime polymerase chain reaction (qRT-PCR) was used detect miR-330 expression serum. Receiver operating...
Background: Metabolic disorder is a key factor in the occurrence and development of tumors. Metabolomics methods can explore variety prognostic markers for Methods: The 454 patients included this study comprised 92 cases gastric cancer, 51 ulcers, 206 polyps, 105 gastritis. plasma levels 23 amino acids before treatment were detected by liquid chromatography-tandem mass spectrometry, t-test was used to determine difference between cancer group other groups. Shared different selected analyze...
We aimed to explore the impacts of rs776746 polymorphism in CYP3A5 gene and smoking on prognosis non-small-cell lung cancer (NSCLC).Our study enrolled 104 early NSCLC patients undergoing surgery 107 advanced chemotherapy, hospitalized between December 2009 2012 at First Affiliated Hospital Liaoning Medical University. All subjects with complete follow-up data were pathologically diagnosed. The different genotypes (*1/*1, *1/*3, *3/*3) identified by polymerase chain-reaction restriction...
Arginine is one of the human nonessential amino acids critical for growth cancers. The aim this study to investigate variation arginine between breast cancer (BC) patients and benign mammary gland disease (control) determine its value in predicting risk BC. We also explore associations levels subtypes. Preoperative blood samples were obtained from 267 (102 BC 165 controls) 2015. Plasma values determined all preoperative using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyse...
1. UDP-glucuronosyltransferases (UGTs) are important drug-metabolizing enzymes (DMEs) catalyzing the glucuronidation elimination of various xenobiotics and endogenous substances. Endogenous substances regulators for activity UGT isoforms. Triiodothyronine (T3) thyroxine (T4) thyroid hormones essential normal cellular differentiation growth. The present study aims to elucidate inhibition behavior T3 T4 on 2. In vitro recombinant UGTs-catalyzed 4-methylumbelliferone (4-MU) was used screen...
The aim of the present study was to investigate role breast cancer stem cells (BCSCs) in angiogenesis tumors. expression levels mutant p53, cluster differentiation (CD)31, vascular endothelial factor (VEGF), addition human epidermal growth (HER)2, were detected blood vessels (BC) tissue samples. CD44+/CD24-/low selected from single-cell suspensions BC tissues assess CD31 and CD105, ability these metabolize acetylated low-density lipoprotein (Ac-LDL). Furthermore, vascular-like structures...
1. Everolimus is an inhibitor of mammalian target rapamycin (mTOR) and has been clinically utilized to prevent the rejection organ transplants. This study aims determine inhibition everolimus on activity phase-II drug-metabolizing enzymes UDP-glucuronosyltransferases (UGTs). 2. The results showed that 100 μM exerted more than 80% toward UGT1A1, UGT-1A3 UGT-2B7. UGT1A3 UGT2B7 were selected elucidate mechanism, in silico docking hydrogen bonds hydrophobic interactions mainly contributed strong...
Pyocyanin, an extracellular product of Pseudomonas aeruginosa (P. aeruginosa), is important in invasive pulmonary infection. infections are characterized by a marked influx polymorphonuclear cells (neutrophils). An increased release interleukin-8 (IL‑8), potent neutrophil chemoattractant, response to pyocyanin may contribute the infiltration neutrophils and subsequent neutrophil‑mediated tissue damage observed Pseudomonas‑associated lung diseases. In order explore pathogenesis on...
Maternal embryonic leucine zipper kinase (MELK) is involved in the development and progression of various cancers. This work investigated usefulness MELK prediction hepatocellular carcinoma (HCC) prognosis.Information on expression was obtained by pan-cancer analysis using The Cancer Genome Atlas (TCGA) database. TCGA-liver hepatic cancer (TCGA-LIHC), Oncomine datasets, International Consortium (ICGC) datasets were used to investigate HCC. prognostic roles HCC assessed univariate...
Eosinophils have the potential to exhibit both anti-tumor properties and tumor-promoting effects. However, impact of eosinophil levels in bloodstream on tumorigenesis risk remains inadequately explored. Furthermore, investigations regarding association between drugs regulating eosinophils cancer are currently absent. In this study, we conducted a Mendelian randomization (MR) analysis utilizing count percentage as exposures. cohorts, significant was observed colorectal skin malignancies. upon...