A5100423173- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- RNA regulation and disease
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Colorectal Cancer Screening and Detection
- Mycobacterium research and diagnosis
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- High Altitude and Hypoxia
- Biosensors and Analytical Detection
- Postharvest Quality and Shelf Life Management
- Oropharyngeal Anatomy and Pathologies
- Salivary Gland Disorders and Functions
- Ferroptosis and cancer prognosis
- Breast Implant and Reconstruction
Nanfang Hospital
2024-2025
Southern Medical University
2024-2025
Beihang University
2025
Fifth Hospital In Wuhan
2025
Wuhan University
2022-2025
Tianjin Medical University
2022-2024
Bengbu Medical College
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2023
Chongqing Medical University
2020-2023
Ningbo University
2023
Under hypoxia, most of glucose is converted to secretory lactate, which leads the overuse glutamine-carbon. However, under such a condition how glutamine nitrogen disposed avoid over-accumulating ammonia remains be determined. Here we identify metabolic flux dihydroorotate, indispensable glutamine-carbon metabolism hypoxia. We found that necessary nucleotide biosynthesis, but enriched in dihyroorotate and orotate rather than processing its downstream uridine monophosphate Dihyroorotate, not...
Abstract Background Exosome-mediated crosstalk between cancer cells and immune contributes to tumor growth. In this study, we investigated the mechanism underlying exosome-mediated escape of colorectal (CRC) from natural killer (NK) via transfer long noncoding RNAs (lncRNAs). Methods An epithelial–mesenchymal transition (EMT) model SW480 was established by transforming growth factor beta (TGF-β), followed assessment effect EMT-derived exosomes (EMT-exo) on functions NK cells. RNA sequencing...
// Wenqiao Zang 1 , Tao Wang 2 Yuanyuan Xiaonan Chen Yuwen Du Qianqian Sun Min Li Ziming Dong 1, 3 Guoqiang Zhao College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China Department Hemato-tumor, The First Affiliated Hospital Henan University TCM, Collaborative Innovation Center Cancer Chemoprevention, Henan, Correspondence to: Zhao, e-mail: zhaogq@zzu.edu.cn Keywords: LncRNA TP73-AS1, BDH2, biomarker, chemosensitivity, esophageal cancer Received: July 24, 2015 Accepted:...
The redox homeostasis system regulates many biological processes, intracellular antioxidant production and signaling. However, long noncoding RNAs (lncRNAs) involved in regulation have rarely been reported. Herein, we reported that downregulation of MAGI2-AS3 decreased the superoxide level Human fibroblasts (Fbs), a replicative aging model, as detected by fluorescent probes dihydroethidium (DHE) MitoSOX™ Red. RNA pulldown combined with mass spectrometry showed HSPA8 is novel interacting...
MicroRNAs are small non-coding RNAs that may also function as oncogenes and tumor-suppressor genes, the abnormal expression of microRNAs is associated with various human tumors. However, effect miR-335 on lung cancer cells remains unclear. The aim paper was to study miR335 in non-small cell (NSCLC) miR335's relation metastasis, invasion, apoptosis A549 H1299. qRT-PCR used identify expression. effects proliferation, apoptosis, invasion were further analyzed. Luciferase reporter assay Western...
Patients with gastric ulcer (GU) have a significantly higher risk of developing cancer (GC), especially within 2 years after diagnosis. The main way to improve the prognosis GC is predict tumorigenesis and metastasis in early stage. objective this study was demonstrate ability human plasma amino acid metabolic profile for discriminating GU. In study, we first used liquid chromatography-tandem mass spectrometry technique characterize metabolism GU patients. Plasma samples were collected from...
Abstract Stereotactic body radiotherapy (SBRT) has emerged as a standard treatment for non-small-cell lung cancer. However, its therapeutic advantages are limited with the development of SBRT resistance. The SBRT-resistant cell lines (A549/IR and H1975/IR) were established after exposure hypofractionated irradiation. differential lncRNAs screened by microarray assay, then expression was detected in LUAD tumor tissues qPCR. influence on radiation response assessed via vitro vivo assays,...
MicroRNAs (miRNAs) are small non-coding RNAs that, by targeting certain messenger (mRNAs) for translational repression or cleavage, can regulate the expression of these genes. In addition, miRNAs may also function as oncogenes and tumor-suppressor genes, abnormal is associated with various human tumors. However, effects miR-124 in breast cancer remain unclear. The present study was conducted to cancer, paying particular attention miR-124's relation proliferation, invasion, apoptosis cell...
Lung cancer, predominantly non-small-cell lung cancer (NSCLC), is the leading cause of deaths worldwide. There a great need to identify critical effectors involved in metastasis NSCLC that will facilitate development new therapeutic strategies. Here we evaluated potential role miR-125b cells.Human cells were isolated from surgical tissues with Cancer Cell Isolation Kit. Expressions and TP53INP1 detected real-time PCR western blot. Human mimics, inhibitor, expression plasmid siRNA transfected...
Breast cancer (BC) is a common malignancy worldwide. It has been reported that long non-coding RNA (lncRNA) HOX transcript antisense (HOTAIR) abnormally expressed in BC. However, the role of HOTAIR BC worth further discussion. This study aims to clarify function and molecular mechanism BC.Quantitative real-time polymerase chain reaction (qRT-PCR) was employed determine expression HOTAIR, microRNA (miR)-601 zinc finger E-box binding homeobox 1 (ZEB1). Cell counting kit-8 (CCK-8) transwell...
Abstract Background MicroRNAs (miRNAs) can act as either oncogenes or tumor suppressor genes under different conditions and thus play a significant role in cancer development. We investigated miR-655 expression cohort of esophageal squamous cell carcinoma (ESCC) to assess the impact this miRNA on ESCC invasion metastasis. Methods A qRT-PCR assay was used quantify levels 34 paired samples adjacent non-tumor tissues. Wound healing transwell assays were evaluate effects invasiveness cells....
MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, including breast cancer. We evaluated miR‑365 expression cancer tissues, investigated its effects on cell growth, cycle, invasion, target gene ADAMTS-1. levels were analyzed tissues adjacent normal using qRT-PCR. CCK-8, invasion assays used to explore role cells. conducted luciferase reporter western blot test whether ADAMTS-1 is a direct miR‑365. found that significantly higher compared with non-tumor...
The high mobility group-box 3 (HMGB3) protein belongs to the group box (HMG-box) subfamily, and recent studies have shown that HMGB3 is an oncogene for leukemia. also expressed at a level in progression phase of breast gastric cancer (GC). Using bioinformatic analyses, we found potential target miR-513b. However, pathophysiological role miR-513b its relevance growth development GC yet be investigated. This study focuses on whether acts as tumor suppressor GC. Compared with non-malignant...
Thyroid cancer is one of the most common types in endocrine system. Among all thyroid cancer, papillary carcinoma (PTC) type cancer. Long non‑coding RNA (lncRNA) BRAF‑activated non‑protein‑coding (BANCR) a 688‑bp‑long nucleotide transcript, which was first identified melanoma. The function BANCR remains unclear. aim present study to investigate whether involved development results indicated that expression increased tumors compared with adjacent normal tissues. cell lines, level differed:...
Lung cancer is the most common cause of cancer-related mortality worldwide. It a complex disease involving multiple genetic and epigenetic alterations. The development transcriptomics revealed important role long non-coding RNAs (lncRNAs) in lung occurrence development. Here, microarray analysis adenocarcinoma tissues showed abnormal expression lncRNA RGMB-AS1. However, RGMB-AS1 remains largely unknown. We that upregulation was significantly correlated with differentiation, TNM stage, lymph...
Many long non-coding RNAs (lncRNAs) have emerged as good biomarkers and potential therapeutic targets for various cancers. We aimed to get a detailed understanding of the lncRNA landscape that is associated with lung cancer survival. A comparative analysis between our RNA sequencing (RNA-seq) data TCGA datasets was conducted reveal lncRNAs significant correlations survival then association most promising validated in cohort 243 patients. Comparing RNA-seq ones, 84 dysregulated were...
The key circadian genes, Period1(Per1), Period2(Per2), and Period3(Per3), constitute the mammalian Period gene family. abnormal expression of Per1 Per2 is closely related to tumor development, but there are few reports on Per3 tumorigenesis. This study was conducted determine whether could influence progression astroblastoma. results indicated that level increased in astroblastoma cells, high correlated with poor overall survival time glioma patients. role cells then investigated using two...