A5079412899- Cancer Cells and Metastasis
- Tuberculosis Research and Epidemiology
- Chromosomal and Genetic Variations
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cannabis and Cannabinoid Research
- Inhalation and Respiratory Drug Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related gene regulation
- Soil and Unsaturated Flow
- Renal and related cancers
- Alcohol Consumption and Health Effects
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Immunodeficiency and Autoimmune Disorders
- Cholesterol and Lipid Metabolism
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Advanced biosensing and bioanalysis techniques
- CO2 Sequestration and Geologic Interactions
- Diagnosis and treatment of tuberculosis
- Groundwater flow and contamination studies
Xiamen University
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2016
Chongqing Medical University
2014-2016
University of California, Los Angeles
1996-2002
University of California, Irvine
2002
Brigham and Women's Hospital
2002
West Virginia University
2002
Harvard University
1999-2002
Boston Children's Hospital
1999
University of Alberta
1994-1997
Angiogenesis is implicated in the pathogenesis of cancer, rheumatoid arthritis, and atherosclerosis treatment coronary artery peripheral vascular disease. Here, cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are shown to interfere with angiogenesis. In vivo, HMG-CoA inhibitor simvastatin dose-dependently inhibited capillary growth both endothelial factor–stimulated chick chorioallantoic membranes basic fibroblast mouse corneas. vitro,...
ABSTRACT Extracytoplasmic function (ECF) sigma factors are a heterogeneous group of alternative that regulate gene expression in response to variety conditions, including stress. We previously characterized mycobacterial ECF factor, SigE, contributes survival following several distinct stresses. A encoding closely related sigH , was cloned from Mycobacterium tuberculosis and smegmatis . single copy this is present these other fast- slow-growing mycobacteria, M. fortuitum avium While the...
MicroRNAs (miRNAs) are a class of small non‑coding single‑stranded RNAs that regulate gene expression at the posttranscriptional level. Since identification miRNA, accumulating research has shown their involvement in numerous biological processes, including timing developmental patterning, embryogenesis, cell differentiation, organogenesis, growth control and pathogenesis human diseases. It is estimated >30% genes may be regulated by each miRNA can >100 target mRNAs. The widespread distinct...
The human interleukin 2 (huIL-2) gene was introduced into Mycobacterium bovis BCG by using the integrative vector pMV306. To express and secrete huIL-2 from BCG, two different plasmids, CI CII, were made. In CI, huIL-2-encoding region under control of alpha-antigen promoter BCG; in expression regulated heat shock protein 60 promoter. A signal peptide sequence isolated naturally secreted inserted between to facilitate secretion. Both plasmids integrated genome when Pasteur strain...
We have previously demonstrated that growth of embryonic chick atrial cells in medium supplemented with lipoprotein-depleted serum (LPDS) resulted a coordinate increase the expression genes involved parasympathetic response heart (the M 2 muscarinic receptor; α-subunit heterotrimeric G protein, Gα i2 ; and inward rectifying K + channel GIRK1) marked negative chronotropic to stimulation. In present study, we demonstrate regulation promoter activity by LPDS is mediated binding sterol...
In Drosophila melanogaster, mutations in Su(var) and En(var) loci either suppress or enhance position effect variegation, respectively. Towards the cloning of these genes we have induced, recovered, characterized a series located on third chromosome. These were recovered from P-element mutagenesis scheme which chromosome P[ry + Δ2–3](99B) element would provide transposase trans to mobilize single nonautonomous P transposon, P[pUCHSNeo](9C), X Although this cross induces mobilization...