A5026487779- Mesenchymal stem cell research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Neuroscience and Neuropharmacology Research
- Psoriasis: Treatment and Pathogenesis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Circular RNAs in diseases
- Blood transfusion and management
- Cardiac Ischemia and Reperfusion
- Bacteriophages and microbial interactions
- Drug-Induced Adverse Reactions
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hemostasis and retained surgical items
- Antiplatelet Therapy and Cardiovascular Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Pulmonary Hypertension Research and Treatments
Air Force Medical University
2016-2025
Xijing Hospital
2016-2025
Tianjin Medical University
2025
Nanjing Medical University
2021-2025
Second Affiliated Hospital of Jilin University
2003-2025
Wuhan Children's Hospital
2025
Huazhong University of Science and Technology
2025
Jiangsu Province Hospital
2024
Lanzhou University
2014-2022
Lanzhou University Second Hospital
2014-2022
Neutrophils have a pathogenic function in inflammation via releasing pro-inflammatory mediators or neutrophil extracellular traps (NETs). However, their heterogeneity and mechanisms remain unclear. Here, we demonstrate that CXCR4hi neutrophils accumulate the blood inflamed skin human psoriasis, correlate with disease severity. Compared to CXCR4lo neutrophils, enhanced NETs formation, phagocytic function, degranulation, overexpression of cytokines chemokines vitro. This is accompanied by...
Reactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 inhibits its activity. Using three genetic models, demonstrate protects against male mice. Mechanistically, suppresses STAT signaling mitochondrial function scavenging hydrogen peroxide,...
Portable, low-cost, and quantitative detection of cancer cells at home in the field has potential to revolutionize medical diagnostics. We first report design synthesis highly efficient folic-acid-conjugated hydrogen-generation tube-in-tube CuO/Co3O4 heterojunction nanofibers for sensitive rapid recognition through a pressure signal under visible-light irradiation. The resultant can dramatically enhance activity ammonia borane Such reaction translate molecular event between folic acid folate...
Several studies have reported that microRNA (MIR) is involved in the pathogenesis and progression of ischemic diseases, including cerebral ischemia, MIR-22 may inhibit inflammatory response cell apoptosis, which contribute to ischemia/reperfusion (I/R) injury. However, specific function I/R injury remains far from clear. This study aimed examine potential protective effect against its mechanism. As predicted, adenovirus-mediated overexpression markedly reduced neurological score infarct size...
The timely administration of platelet transfusions is critical for patient survival, and the clinical demand has been steadily increasing. However, storage lesions (PSLs) that develop during in vitro preservation exacerbate these shortages. PSL significantly influenced by various factors, including temperature, gas composition, buffering systems. Strategies to mitigate PSLs improve have actively explored recent years. This study aimed investigate whether elevated carbon dioxide (CO2) levels...
Abstract Researchers commonly use cyclization recombination enzyme/locus of X-over P1 (Cre/loxP) technology-based conditional gene knockouts model mice to investigate the functional roles genes interest in Sertoli and Leydig cells within testis. However, shortcomings these genetic tools include high costs, lengthy experimental periods, limited accessibility for researchers. Therefore, exploring alternative silencing techniques is great practical value. In this study, we employed...
Objective To investigate the effectiveness of JAK 1/3 inhibitor tofacitinib in treating Blau syndrome and explore association between various clinical genetic features therapeutic responses within cohort. Methods A five-year, multi-center, retrospective, observational study was conducted across seven centers, focusing on profiles manifestations Genetic analysis, including whole exome sequencing NOD-2 STAT3 rs2293152 phenotypic comparisons, performed to assess responses. Results Baseline data...
The interplay between microbiota and the onset of immune-mediated diseases is increasingly coming to light. However, role tonsillar in cutaneous inflammation remains largely unknown. We aimed determine how influence skin psoriasis uncover underlying molecular mechanisms. Tonsillar samples were collected from 24 healthy controls 28 patients. Microbial community composition was analyzed using 16S rRNA sequencing metagenomic sequencing. Serum levels short-chain fatty acids (SCFAs) measured via...
Tanshinone IIA is an extract of Salvia miltiorrhiza Bunge (Labiatae) used to treat cardiovascular disorders. It shows potential anticonvulsant and cognition-protective properties.We investigated the mechanism tanshinone on antiepileptic effects in model epileptic rats.Lithium chloride (LiCl)-pilocarpine-induced Wistar rats were randomly assigned following groups (n = 12): control (blank), model, sodium valproate (VPA, 189 mg/kg/d, positive control), low dose (TS IIA-L, 10 mg/kg/d), medium...
The purpose of this study was to investigate the expression estradiol and estrogen receptor α (ESRα) in severe preeclamptic (sPE) pregnancies compared with normal pregnancies. Sera placentas were obtained from i) patients sPE (n=25) ii) a control group who underwent elective Cesarean deliveries. Estradiol assessed by enzyme-linked immunosorbent assays (ELISAs). ESRα reverse transcription polymerase chain reaction (RT-PCR) analysis western blot analysis. In pregnancies, underexpressed...
Mesenchymal stromal cells (MSCs) based therapy is a promising approach to treat inflammatory disorders. However, therapeutic effect not always achieved. Thus the mechanism involved in inflammation requires further elucidation. To explore mechanisms by which MSCs respond stimuli, we investigated whether employed inflammasomes participate inflammation. Using vitro and vivo models, found that canonical NLRP3 non-canonical caspase-11 were activated bone-associated (BA-MSCs) promote response. The...
The transient receptor potential vanilloid type 1 (TRPV1) is expressed in the cardiovascular system, and increased TRPV1 expression has been associated with cardiac hypertrophy. Nevertheless, role of pathogenesis hypertrophy underlying molecular mechanisms remain unclear.In cultured cardiomyocytes, activation cell size elevated atrial natriuretic peptide mRNA intracellular calcium level, which was reversed by antagonist capsazepine. Increased phosphorylated calmodulin-dependent protein...
Abstract Background Blood transfusion, a common basic supporting therapy, can lead to acute hemolytic transfusion reaction (AHTR). AHTR poses great risk patients through kidney function damage in short time. Previous reports found that heme from destroyed red blood cells impaired function, and NLR family pyrin domain containing 3 (NLRP3) inflammasome was augmented case of injury. However, the detailed mechanism regarding whether NLRP3 is involved injury not fully understood yet. Methods...
BACKGROUND Platelet (PLT) storage at cold temperatures (4°C) can reduce bacterial contamination and lower the risk of transfusion‐related complications. We compared effects 22 4°C conditions for PLTs to further explore efficiency hemostasis in acute bleeding extended PLT shelf life. STUDY DESIGN AND METHODS Manually prepared (PLT concentrates plasma, not additive solution) were stored 4 22°C. The counts, scanning electronic microscope observations, blood gas indices, biochemical aggregative...
Abstract Background The fate of hematopoietic stem cells (HSCs) is determined by a complex regulatory network that includes both intrinsic and extrinsic signals. In the past decades, many key molecules HSCs have been shown to control hematopoiesis homeostasis. Non-hematopoietic niche also contribute self-renewal, quiescence, differentiation HSCs. Mesenchymal stromal (MSCs) identified as important components niche. However, role MSCs in has not fully understood. Methods Caspase-3 NLRP3 gene...