A5102840990- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- ECG Monitoring and Analysis
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Non-Invasive Vital Sign Monitoring
- Cardiac Arrhythmias and Treatments
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Heart Failure Treatment and Management
- MicroRNA in disease regulation
- Congenital Heart Disease Studies
- Tissue Engineering and Regenerative Medicine
- Coronary Artery Anomalies
- Heart Rate Variability and Autonomic Control
- Nuclear Receptors and Signaling
- Studies on Chitinases and Chitosanases
- RNA Interference and Gene Delivery
- Kawasaki Disease and Coronary Complications
Peking University
2021-2025
Peking University Third Hospital
2021-2025
First Affiliated Hospital of Hebei Medical University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Tianjin haihe hospital
2024
King University
2024
Ministry of Education of the People's Republic of China
2021-2023
Hebei Medical University
2022
Fu Wai Hospital
2011-2017
Nanomaterials that combine multimodality imaging and therapeutic functions within a single nanoplatform have drawn extensive attention for molecular medicines biological applications. Herein, we report theranostic based on relatively smaller (<20 nm) iron oxide loaded porphyrin-grafted lipid nanoparticles (Fe3O4@PGL NPs). The amphiphilic PGL easily self-assembled the hydrophobic exterior surface of ultrasmall Fe3O4 NPs, resulting in final Fe3O4@PGL NPs with diameter ∼10 nm. excellent...
Abstract Background The relationship between stress hyperglycemia and long-term prognosis in acute decompensated heart failure (ADHF) patients is unknown. This study investigated the associations of with mortality rehospitalization rates among ADHF diabetes. Methods We consecutively enrolled 1904 patients. Among them, 780 were Stress was estimated using ratio (SHR), which calculated by following formula: SHR = admission blood glucose/[(28.7 × HbA1c%) – 46.7]. All diabetic subjects divided...
Advanced elastomers are highly demanded for the fabrication of medical devices minimally invasive surgery (MIS). A diselenide-containing, shape-memory and self-healing polyurethane MIS is illustrated in myocardial infarction therapy.
Arrhythmia is a common problem of irregular heartbeats, which may lead to serious complications such as stroke and even mortality. Due the paroxysmal nature arrhythmia, its long-term monitoring early detection in daily household scenarios, instead depending on ECG examination only available during clinical visits, are critical importance. While ambulatory Holter wearables like smartwatches have been used, they still inconvenient interfere with users' activities. In this paper, we bridge gap...
We report a randomized, multicenter, open-label trial (ClinicalTrials.gov: NCT03096613) to investigate the clinical benefits of levothyroxine (L-T4) administration in subclinical hypothyroidism (SCH) patients with heart failure reduced ejection fraction (HFrEF). Overall, 117 were enrolled and received L-T4 plus standard HFrEF treatment (experimental group, N = 57) or therapy alone (control 60). The change 6-min walk test distance experimental group was significantly higher than that control...
To analyze sex and age distribution of global disease burden calcific aortic valve (CAVD) from 1990 to 2021. CAVD data during 1990-2021 were obtained the IHME website for Global Burden Disease (GBD). The prevalence, mortality, years lived with disability (YLDs), disability-adjusted life (DALYs) analyzed by gender groups. Joinpoint regression was used calculate annual percentage change (APC) average (AAPC). In 2021, there 13.32 million patients 142 000 deaths caused globally. Age-standardized...
Macrophages play a crucial role in cardiac remodeling and prognosis after myocardial infarction (MI). Our previous studies have built scalable method for preparing scaled stem cell nanovesicles (NVs) demonstrated their remarkable reparative effects on ischemic heart disease. To further enhance the targeted capabilities of NVs toward injured myocardium, we employed dual modification strategy involving platelet membrane coating miR-181a-5p loading, creating nanovesicle termed P-181-NV. This...
To compare stent strut coverage using optical coherence tomography (OCT) at three-month follow-up between a PLGA-polymer with electro-grafting base layer sirolimus-eluting (SES) (BuMA) and PLA-polymer SES (EXCEL).This prospective, single-centre, non-inferiority randomised BuMA-OCT trial enrolled patients de novo coronary artery lesions, treated either the BuMA or EXCEL stent. The study primary endpoint was OCT-evaluated three months. Secondary endpoints were neointimal thickness of struts,...
Caspase-1 is a key player in pyroptosis and inflammation. inhibition found to be beneficial various diseases. Coumarin-originated natural products have an anti-inflammation function, but their direct effect caspase-1 remains unexplored. To evaluate interactions, the widely used commercial coumarin-based probe (Ac-YVAD-AMC) not suitable, as background signal from coumarin-originated could interfere with screening results. Therefore, fluorescent probes using large Stokes shift help solve this...
The electrocardiogram (ECG) has always served as a crucial biomedical examination for cardiac diseases monitoring and diagnosing. Typical ECG measurement requires attaching electrodes to the body, which is inconvenient long-term monitoring. Recent wireless sensing maps signals reflected from human chest into electrical activities of heart so reconstruct contactlessly. While making great progress, we find existing works are effective only healthy populations with normal ECG, but fall short...
Bevacizumab is a commonly used anticancer drug in clinical practice, but it often leads to adverse reactions such as vascular endothelial damage, hypertension, arterial and venous thrombosis, bleeding. This study investigated the protective effects of metformin against bevacizumab-induced injury mouse model examined possible involvement GDF15/PI3K/AKT/FOXO/PPARγ signaling effects.
Abstract Background Currently, pathophysiological mechanisms of post‐acute sequelae coronavirus disease‐19‐cardiovascular syndrome (PASC‐CVS) remain unknown. Methods and results Patients with PASC‐CVS exhibited significantly higher circulating levels severe acute respiratory syndrome‐coronavirus‐2 spike protein S1 than the non‐PASC‐CVS patients healthy controls. Moreover, individuals high plasma concentrations elevated heart rates normalized low frequency, suggesting cardiac β‐adrenergic...
Abstract Background Large Language Models (LLMs) are increasingly being explored for medical applications, particularly in emergency triage where rapid and accurate decision-making is crucial. This study evaluates the diagnostic performance of two prominent Chinese LLMs, “Tongyi Qianwen” “Lingyi Zhihui,” alongside a newly developed model, MediGuide-14B, comparing their effectiveness with human experts chest pain triage. Methods Conducted at Peking University Third Hospital’s centers from...
The risk of ventricular arrhythmia and heart failure in patients with hypertrophic obstructive cardiomyopathy (HOCM) is much higher than that the general population. More more pieces evidence showed HOCM leading cause sudden cardiac death young people. We reported our experience a study, comparing surgical myectomy, alcohol septal ablation (ASA), medical therapy.The original cohort included 965 consecutive HOCM. were divided into three groups according to treatment strategies: myectomy group...
To investigate whether the very elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI) will benefit from an invasive strategy versus a conservative strategy.190 consecutive aged 80 years or older NSTEMI were included in retrospective study September 2014 to August 2017, of which 69 received and 121 strategy. The primary outcome was death. Multivariate Cox regression models used assess statistical association between strategies mortality. survival probability further...
Myocardial bridging is a common congenital abnormality of coronary artery, and usually thought to be benign anatomical variant. Although rare, previous studies have reported that patients with myocardial may suffer from ischemia, infarction (MI), arrhythmias even sudden death. Here we report the case an 18-year-old adolescent athlete resulting in MI. Coronary angiography revealed 80% luminal narrowing by systolic compression proximal mid segments left anterior descending which returned...
Data on outcomes following transcatheter aortic valve replacement with SAPIEN 3 in China is limited as it was approved by the National Medical Products since 2020. The present study designed to collect clinical data Chinese patients bicuspid and tricuspid stenosis.We analyzed patient characteristics, procedural features of first 438 (223 for 215 valve) from 21 provinces 74 sites treated system between September 2020 May 2022.Procedural mortality 0.7%. 5 cases during operation were converted...
Growing evidences have revealed that a histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA) has anti-fibrotic effect in different diseases. In this study, we first evaluated whether SAHA could suppress cardiac fibrosis. Mice with MI-induced fibrosis were treated by intraperitoneal injection and their function was improved after treatment. Results of western blotting qRT-PCR heart tissues suggested TGFβ1/P38 pathway activated MI mice, reversed SAHA. Cell proliferation...