A5054016978- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Chronic Disease Management Strategies
- Cardiac Arrest and Resuscitation
- Healthcare cost, quality, practices
- Obstructive Sleep Apnea Research
- Acute Kidney Injury Research
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Machine Learning in Healthcare
- Non-Destructive Testing Techniques
- Advanced ceramic materials synthesis
- interferon and immune responses
- Health Promotion and Cardiovascular Prevention
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Sphingolipid Metabolism and Signaling
- Electrical Fault Detection and Protection
Yantai University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Affiliated Hospital of North Sichuan Medical College
2023-2024
State Key Laboratory of Cardiovascular Disease
2018-2024
North Sichuan Medical University
2024
Peking Union Medical College Hospital
2019-2024
Fu Wai Hospital
2018-2024
Northwestern Polytechnical University
2024
Aerospace Research Institute of Materials and Processing Technology
2024
Sichuan University
2022
Sepsis is a systemic inflammatory response caused by infection and leading cause of death worldwide. We designed synthesized series hederagenin analogues with anti-inflammatory activity. The most effective compound, 14, reduced the release TNF-α IL-6 in RAW264.7 cells induced lipopolysaccharide affecting NF-κB/MAPK signaling. It demonstrated significant protection against sepsis vivo ameliorated histopathological changes liver, lungs, kidneys. exhibited good safety subacute toxicity assays....
Background Contrast‐induced acute kidney injury ( CI‐AKI ) is one of the most serious complications in patients who undergo percutaneous coronary intervention PCI ), especially those with syndrome. It has been shown that inflammation may play an important role pathophysiology . Hypothesis Inflammatory factors a predominant prediction emergency Methods Patients underwent from 2013 to 2015 were consecutively enrolled and divided into non– groups. Logistic analysis was used identify risk...
<h3>Importance</h3> The incidence of acute myocardial infarction has increased over the past decades in China, and management challenges include an unbalanced economy, disparate resources, variable access to medical care across nation. <h3>Objective</h3> To examine variations outcomes patients with ST-segment elevation among 3 levels hospitals typical Chinese public hospital model. <h3>Design, Setting, Participants</h3> This cross-sectional study used data from China Acute Myocardial...
Abstract Background Recent publications reported a paradoxical finding that there was an inverse association between the number of standard modifiable risk factors (SMuRFs; smoking, hypertension, diabetes, and hyperlipidemia) mortality in patients with myocardial infarction. However, current evidence is only limited to those highly developed countries advanced medical management systems. Methods The China Acute Myocardial Infarction registry prospective observational study including acute...
Young people hold a stable or increasing percentage of patients with acute myocardial infarction (AMI) in many countries. However, data on clinical characteristics and outcomes young AMI were insufficient. This study aimed to analyze characteristics, prognosis, gender disparities aged ≤45 years AMI.
Only a few randomized trials have analyzed the clinical outcomes of elderly ST-segment elevation myocardial infarction (STEMI) patients (≥ 75 years old). Therefore, best reperfusion strategy has not been well established. An observational study focused on was performed in this population.Based national registry STEMI patients, in-hospital with different strategies were compared. The primary endpoint defined as death. Secondary endpoints included recurrent infarction, ischemia driven...
Background:Accurate risk stratification of non-ST segment elevation myocardial infarction (NSTEMI) patients is important due to great variability in mortality risk, but, date, no prediction model has been available. The aim this study was therefore establish a score predict in-hospital NSTEMI patients.
Approximately 70% patients with acute myocardial infarction (AMI) presented without ST-segment elevation on electrocardiogram. Patients non-ST segment (NSTEMI) often atypical symptoms, which may be related to pre-hospital delay and increased risk of mortality. However, up date few studies reported detailed symptomatology NSTEMI, particularly among Asian patients. The objective this study was describe compare symptoms presenting characteristics NSTEMI vs. STEMI
Diabetes is frequently associated with poor prognosis among acute myocardial infarction (AMI) patients. Patients these comorbidities often have atypical symptoms and subsequent delay in treatment. Few studies reported detailed AMI patients diabetes. This study compared presentation characteristics between diabetics non-diabetics.We included from the China registry diagnosed January 2013 September 2014. Baseline characteristics, symptomology, treatment were non-diabetics. Multivariable...
Introduction Smoking is a well-established risk factor for cardiovascular disease. However, the effect of smoking on in-hospital mortality in patients with acute myocardial infarction (AMI) who are managed by contemporary treatment still unclear. Methods A cohort study was conducted using data from China AMI registry between 2013 and 2016. Eligible were diagnosed accordance third universal definition MI. Propensity score (PS) matching multivariable logistic regression used to control...
Acute ST-segment elevation myocardial infarction (STEMI) remains a serious life-threatening event. Despite coronary revascularization, patients might still suffer from poor outcomes caused by no-reflow and ischemic/reperfusion injury. Tongxinluo (TXL), traditional Chinese medicine, has been preliminarily demonstrated to reduce We further hypothesize that TXL treatment is also effective in reducing clinical end points for the with STEMI. The CTS-AMI trial prospective, randomized,...
Abstract Background Data on fibrinolytic therapy use for ST-segment elevation myocardial infarction (STEMI) and long-term clinical outcomes in developing countries are limited. We aimed to investigate the management 2-year mortality of fibrinolytic-treated patients China. Methods A total 19,112 with STEMI from 108 hospitals participated China Acute Myocardial Infarction registry between January 2013 September 2014. investigated all-cause among treated fibrinolysis. Non-invasive indexes were...
Background Obstructive sleep apnea ( OSA ) is common and independently associated with atrial fibrillation AF in patients hypertrophic cardiomyopathy HCM ). This study aimed to investigate the relationship between apnea‐hypopnea index AHI ), a measure of severity, prevalence large series HCM. Methods Results A total 555 who underwent evaluations were retrospectively included. Data from polysomnography studies, echocardiography, baseline clinical characteristics collected. was present 327...
Objectives The risk of adverse events and prognostic factors are changing in different time phases after acute myocardial infarction (AMI). incidence is considerable the early period AMI hospitalisation. Therefore, dynamic prediction needed to guide postdischarge management AMI. This study aimed develop a instrument for patients following Design A retrospective analysis prospective cohort. Setting 108 hospitals China. Participants total 23 887 China Acute Myocardial Infarction Registry were...
Background To evaluate the role of ST-segment resolution (STR) alone and in combination with Thrombolysis Myocardial Infarction (TIMI) flow reperfusion evaluation after primary percutaneous coronary intervention (PPCI) for ST-segment-elevation myocardial infarction by investigating long-term prognostic impact. Methods Results From January 2013 through September 2014, we studied 5966 patients enrolled CAMI (China Acute Infarction) registry available data STR evaluated at 120 minutes PPCI....