A5100725978- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Demographic Trends and Gender Preferences
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Cardiac and Coronary Surgery Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Cleft Lip and Palate Research
- Cardiovascular Function and Risk Factors
- Drug Transport and Resistance Mechanisms
- Craniofacial Disorders and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Global Maternal and Child Health
- Cardiac Fibrosis and Remodeling
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Congenital Ear and Nasal Anomalies
- Liver Diseases and Immunity
Chinese Academy of Medical Sciences & Peking Union Medical College
2004-2024
State Key Laboratory of Medical Molecular Biology
2023-2024
Tangshan Gongren Hospital
2024
Jiangxi Provincial People's Hospital
2024
Xiamen University
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Bengbu Medical College
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Abstract Aims Interleukin (IL)-5 mediates the development of eosinophils (EOS) that are essential for tissue post-injury repair. It remains unknown whether IL-5 plays a role in heart repair after myocardial infarction (MI). This study aims to test IL-5-induced EOS population promotes healing and process post-MI reveal underlying mechanisms. Methods results MI was induced by permanent ligation left anterior descending coronary artery wild-type C57BL/6 mice. Western blot real-time polymerase...
Influenza A viruses (IAVs) pose a persistent potential threat to human health because of the spillover from avian and swine infections. Extensive surveillance was performed in 12 cities Guangxi, China, during 2018 2023. total 2540 samples (including 2353 nasal swabs 187 lung tissues) were collected 18 pig farms with outbreaks respiratory disease. From these, 192 IAV-positive 19 genomic sequences obtained. We found that H1 H3 influenza (swIAVs) multiple lineages genotypes have continued...
Abstract Background: Acute respiratory distress syndrome (ARDS) is a common cause of failure in many critically ill patients. Although inflammasome activation plays an important role the induction acute lung injury (ALI) and ARDS, regulatory mechanism this process still unclear. When cells are stimulated by inflammation, integrity physiological function mitochondria play crucial part pyroptosis. However, underlying mechanisms mitochondrial proteins pyroptosis largely not yet known. Here, we...
Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in peripheral organs as well the brain and frequent cause late morbidity death after bone-marrow transplantation. In periphery, bone-marrow-derived macrophages are key drivers pathology, but recent evidence suggests that these cells also infiltrate into cGVHD-affected brains. Microglia persistently activated brain. To...
Diabetes is frequently associated with poor prognosis among acute myocardial infarction (AMI) patients. Patients these comorbidities often have atypical symptoms and subsequent delay in treatment. Few studies reported detailed AMI patients diabetes. This study compared presentation characteristics between diabetics non-diabetics.We included from the China registry diagnosed January 2013 September 2014. Baseline characteristics, symptomology, treatment were non-diabetics. Multivariable...
Acute ST-segment elevation myocardial infarction (STEMI) remains a serious life-threatening event. Despite coronary revascularization, patients might still suffer from poor outcomes caused by no-reflow and ischemic/reperfusion injury. Tongxinluo (TXL), traditional Chinese medicine, has been preliminarily demonstrated to reduce We further hypothesize that TXL treatment is also effective in reducing clinical end points for the with STEMI. The CTS-AMI trial prospective, randomized,...
We report the development of Zr/Ce-MOFs/DOX/MnO 2 as a new nanozyme for enhanced combination catalytic therapy and chemotherapy cancer in vitro vivo .
Chronic heart failure (CHF) is the terminal stage of several diseases. The present study aimed to investigate impact palliative care on physical and mental status quality life patients with CHF.This single-center randomized controlled clinical trial was conducted at Xiangtan Central Hospital. A total 103 cases were included divided into a group (n = 54) control 49). received usual care, whereas plus care. Statistical analyses Simplified Coping Style Questionnaire, negative emotions,...
As one common disease causing young people to die suddenly due cardiac arrest, arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder of heart muscle whose progression covers complicated gene interaction network that influence the diagnosis and prognosis it. In our research, differentially expressed genes (DEGs) were screened, we established weighted coexpression analysis(WGCNA) set net correlations analysis (GSNCA) for identifying crucial as well pathways related ARVC...
Aim: To determine the efficacy and safety of intracoronary infusion autologous bone marrow mesenchymal stem cells (MSCINJ) in combination with intensive atorvastatin (ATV) treatment for patients anterior ST-segment elevation myocardial infarction-elevation infarction. Patients & methods: The trial enrolls a total 100 ST-elevation subjects are randomly assigned (1:1:1:1) to receive routine ATV (20 mg/d) placebo or MSCsINJ (80 MSCsINJ. primary end point is absolute change left ventricular...
Pancreatic cancer is a malignancy that affects the digestive tract and has low 5-year survival rate of lower than 15%. Owing to its genetic mutation metabolic complexity, pancreatic difficult treat with surgical resection, radiotherapy, chemotherapy. The predominant modality ductal adenocarcinoma (PDAC), primarily attributed mutations in KRAS gene. Ferroptosis, an iron-mediated reactive oxygen species (ROS)-elevated nonapoptotic cell death caused by lipid peroxidation, distinct from any...
Despite increasing adoption of the transradial approach for percutaneous coronary intervention (PCI) in clinical practice, role (TRI) women remains a significant debate. We identified 1392 from consecutive cohort patients undergoing PCI China 2010 and compared efficacy hospital costs between TRI transfemoral intervention. An inverse probability weighting (IPW) method was used to control potential bias. After IPW adjustment, receiving were less likely experience post-PCI bleeding (adjusted...
Atherosclerotic cardiovascular disease (ASCVD) caused by atherosclerosis (AS) is one of the highest causes mortality worldwide. Although there have been many studies on AS, its etiology remains unclear. In order to carry out molecular characterization different types we retrieved two datasets composed 151 AS samples and 32 normal from Gene Expression Omnibus database. Using non-negative matrix factorization (NMF) algorithm, successfully divided into subgroups. We then compared...
Over the past decades, transradial approach for percutaneous coronary intervention (PCI) has been increasingly adopted in clinical practice. Women represent a large population who will possibly benefit from PCI, but they are often under-represented studies. Therefore, role of TRI women remains to be further defined. This study sought compare safety and efficacy (TRI) transfemoral (TFI) undergoing PCI China.The consisted 5,067 at Fuwai Hospital, Beijing, China between 2006 2011 (TRI: n=4,105,...
This study investigated early and midterm outcomes after valve-sparing aortic root replacement (VSSR procedure with De Paulis Valsalva graft) for acute dissection or ascending aneurysm in a single Chinese hospital center.Between September 2005 to July 2013, 38 patients (84.2% male; mean age, 45.5 ± 12.4) underwent VSSR valsalva graft were followed up clinically echocardiographically.Among the cases studied, intensive care unit stay duration was 34.5 (interquartile range, 16-34.6) days; 11.7...