A5100435098- Reproductive Biology and Fertility
- Infection Control and Ventilation
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Cardiac Valve Diseases and Treatments
- Prostate Cancer Treatment and Research
- Advanced Drug Delivery Systems
- Pluripotent Stem Cells Research
- Flow Measurement and Analysis
- Aortic Disease and Treatment Approaches
- Medical Image Segmentation Techniques
- Infection Control in Healthcare
- Microtubule and mitosis dynamics
- Inhalation and Respiratory Drug Delivery
- Cancer Cells and Metastasis
- Electrical and Bioimpedance Tomography
- Maternal Mental Health During Pregnancy and Postpartum
- Immune Response and Inflammation
- Enhanced Recovery After Surgery
- COVID-19 epidemiological studies
- Diabetes Management and Education
- Prostate Cancer Diagnosis and Treatment
- Cardiovascular Health and Risk Factors
- Acute Lymphoblastic Leukemia research
- AI and Multimedia in Education
Aerospace Center Hospital
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
China Medical University
2012-2023
Xi'an University of Architecture and Technology
2022-2023
Air Liquide (France)
2023
Shandong Center for Disease Control and Prevention
2023
Xuzhou Medical College
2023
First Hospital of China Medical University
2023
University of Augsburg
2022
Abstract Oestrogen receptor alpha (ERα) is a well-known target of endocrine therapy for ERα-positive breast cancer. ERα-negative cells, which are enriched during therapy, associated with metastatic relapse. Here we determine that loss ERα in the invasive front and lymph node metastasis human cancer significantly correlated lymphatic metastasis. Using vivo vitro experiments, demonstrate inhibits Furthermore, find novel regulator vinculin expression Notably, suppresses amoeboid-like movement...
Cerebral microbleeds are microscopic hemorrhages with deposits of blood products in the brain, which can be visualized MRI and implicated cerebrovascular diseases. Hematoxylin eosin (H&E) Perl’s Prussian blue popular staining methods used to localize cerebral pathology. This paper compared these two techniques a mouse model microbleeds. We lipopolysaccharide (LPS) induce microhemorrhages. C57B6 mice were treated LPS (5 mg/kg, i.p.) or vehicle at baseline 24 hr. The brains extracted 48 hr...
Objective To assess the effectiveness of a coach-led motivational interviewing (MI) intervention in improving glycaemic control, as well clinical, psychosocial and self-care outcomes individuals with type 2 diabetes mellitus (T2DM) compared usual care. Design Pragmatic cluster randomised controlled trial (RCT). Setting Community Health Stations (CHSs) Fengtai district, Beijing, China. Participants Of 41 CHSs (21 20 control), 21 (372 participants) 18 control (296 started participation....
Montmorillonite-loaded solid lipid nanoparticles with good biocompatibility, using Betaxolol hydrochloride as model drug, were prepared by the melt-emulsion sonication and low temperature-solidification methods drug bioavailability was significantly improved in this paper for first time to application eye. The appropriate physical characteristics showed, such mean particle size, Zeta potential, osmotic pressure, pH values, entrapping efficiency (EE%) content (DC%), all showed well suited...
Colon cancer stem cell (cCSC) is considered as the seed of colon initiation and metastasis. Cyclooxygenase-2 (COX2), a downstream target NFκB, found to be essential in promoting renewal. However, how COX2 dysregulated cCSCs largely unknown. In this study, we that expression transcription factor FOXP3 was much lower spheroids than parental tumor cells. Overexpression significantly decreased numbers spheres, reduced side population. Accordingly, size weight xenograft model. The inhibitory...
The outcomes of extended subtotal facial nerve decompression via the transmastoid approach were good for palsy after temporal bone fracture (TBF). Surgical should be carried out as soon possible within 8 weeks trauma.To present TBF and to describe our experience management in TBF.A consecutive clinical series was reviewed retrospectively. Eighteen cases that underwent (decompression from stylomastoid foramen labyrinthine segment) due involving perigeniculate ganglion region analyzed....
Abstract Cerebral venous sinus thrombosis (CVST) combined with intracerebral hemorrhage(ICH) is a special subgroup, and whether intrasinus thrombolysis (IST) or mechanical thrombectomy (MT) therapy should be carried out controversial because of previous hemorrhage possible delayed hemorrhage.The aim this study was to analyze the safety effectiveness endovascular treatment CVST ICH further discuss strategy. This retrospective 56 cases admitted from January 2010 June 2019 diagnosed ICH, all...
Objectives: To describe our multi-institutional experience with robotic repair of iatrogenic urogynecologic fistulae (UGF), including vesicovaginal (VVF) and ureterovaginal (UVF). Methods: We performed a retrospective review identifying patients who underwent VVF UVF between January 2010 May 2019. All failed conservative management Foley catheter or upper tract drainage (ureteral stent and/or nephrostomy tube), respectively. Patient demographics perioperative outcomes were analyzed. Success...
The present study aimed to characterize the specific pathology and magnetic resonance imaging (MRI) findings observed in patients with leukemia central nervous system (CNS) lesions, determine their value management of such patients. Lesions CNS were during following treatment leukemia. data from stereotactic biopsy-proven (12 patients) MRI examinations (14 retrospectively evaluated. Proton-magnetic resonance-spectroscopy was performed three Factors that predisposed lesions reviewed patient...
In the present study, we describe development of betaxolol hydrochloride and montmorillonite with ion exchange in a single formulation to create novel micro-interactive dual-functioning sustained-release delivery system (MIDFDS) for treatment glaucoma. Betaxolol molecule was loaded onto by MIDFDS formation confirmed XPS data. showed similar physicochemical properties those Betoptic, such as particle size, pH, osmotic pressure, rheological properties. Nevertheless, microdialysis intraocular...
ABSTRACT In mammalian growing follicles, oocytes are arrested at the diplotene stage (which resembles G2/M boundary in mitosis), while granulosa cells (GCs) continue to proliferate during follicular development, reflecting a cell cycle asynchrony between and GCs. Hypoxanthine (Hx), purine present fluid, has been shown induce meiotic arrest, although its role GC proliferation remains ill-defined. Here, we demonstrate that Hx indiscriminately prevents G2-to-M phase transition porcine However,...
Body-worn sensors (BWS) could provide valuable information in the management of Parkinson's disease and support therapeutic decisions based on objective monitoring. To study this pivotal step better understand how relevant is extracted from BWS results translated into treatment adaptation, eight neurologists examined virtual cases composed basic patient profiles their monitoring results. Sixty-four interpretations subsequent were collected. Relationship between interrater agreements reading...
Background: A total of 79 cases dengue fever were reported in Jining County 2017, which is currently the northernmost focal point local diagnosed China. This study aimed to evaluate density mosquito vectors before and after outbreak provide novel reference data for prevention control disease. Methods: The light traps set collect mosquitoes 2017 2018 assess adult species composition. We used human-baited double net trap determine biting rate. In addition, Breteau index (BI) was calculated...
Calcium (Ca2+)/calmodulin-dependent protein kinase II (CaMKII) had been reported to play a role in the process of fertilization. However, CaMKII release diplotene-arrested oocytes is poorly understood. In this study, we explored potential effect on Akt1 and relationship among CaMKII, phosphatidylinositol (3,4,5)-trisphosphate (PIP3) during meiotic resumption mouse oocytes. We found that inhibition aggravated diplotene arrest. detected expression distribution pCaMKII (Thr286), pAkt1 (Ser473),...