A5008833674- COVID-19 Clinical Research Studies
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Treatments and Mutations
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Acute Myocardial Infarction Research
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Heme Oxygenase-1 and Carbon Monoxide
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Coronary Interventions and Diagnostics
- Transplantation: Methods and Outcomes
Wuhan University
2004-2024
Renmin Hospital of Wuhan University
2004-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Weatherford College
2020-2021
Shanghai Chest Hospital
2016
Shanghai Jiao Tong University
2016
Huazhong University of Science and Technology
2010-2014
Tongji Hospital
2010-2014
PurposeAimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia.MethodsAsymptomatic pneumonia confirmed by SARS-COV-2 nucleic acid testing in Renmin Hospital Wuhan University were retrospectively enrolled. The characteristics feature collected analyzed.Results58 admitted our hospital between Jan 1, 2020 Feb 23, All patients had history exposure SARS-CoV-2. On admission, no symptoms laboratory findings normal. predominant this cohort was ground...
Itaconate, a metabolite produced during inflammatory macrophage activation, has been extensively described to be involved in immunoregulation, oxidative stress, and lipid peroxidation. As form of iron hydroperoxide-dependent regulated cell death, ferroptosis plays critical role sepsis-induced acute lung injury (ALI). However, the relationship between itaconate remains unclear. This study aims explore regulatory on ALI. In vivo experiments, mice were injected with LPS (10 mg/kg) for 12 h...
Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSC
Background: Exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) have been considered as a promising cell-free therapeutic strategy for ischemic heart disease. Cardioprotective drug pretreatment could be an effective approach to improve the efficacy of MSC-exo. Nicorandil has long used in clinical practice cardioprotection. This study aimed investigate whether effects exosomes nicorandil pretreated MSC (MSC NIC -exo) enhanced facilitating cardiac repair after acute myocardial...
// Chengcao Sun 1, 2, * , Zhidong Liu 3, Shujun Li 4, Cuili Yang 1 Ruilin Xue Yongyong Xi Liang Wang Suqing Qiqiang He Jie Huang 5 Songping Xie Wenyang Jiang Dejia Department of Occupational and Environmental Health, School Public Wuhan University, 430071, P. R. China 2 Institute Global 3 Thoracic Surgery, Beijing Chest Hospital, Capital Medical 101149, P.R. 4 Hospital for the Prevention Treatment Diseases, People's 430000, These authors have contributed equally to this work Correspondence...
Fine particulate matter (PM2.5) is one of the most important components environmental pollutants and associated with lung injury. Pyroptosis, a form programmed cell death mainly mediated by NLRP3 inflammasome, has been reported to be involved in sepsis-induced or ischemia/reperfusion-induced However, specific mechanisms pyroptosis PM2.5-induced injury are not yet clear. We constructed macrophage-specific knockout mice explore mechanism terms inflammatory response, oxidative stress, apoptosis...
Abstract Background Bone marrow cells (BMCs), especially mesenchymal stem (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation clinical translation. Based on anti-inflammation and anti-apoptosis effects of a Chinese medicine-Tongxinluo (TXL), we aimed to explore TXL-pretreated MSCs (MSCs TXL ) enhancing cardiac repair further investigated underlying mechanism. Methods or derived exosomes -exo...
Abstract Lung cancer remains the leading cause of cancer‐related death all over world. In spite great advances made in surgery and chemotherapy, prognosis lung patients is poor. A substantial fraction long noncoding RNAs (lncRNAs) can regulate various cancers. recent study has reported that lncRNA HOXB‐AS3 plays a critical role However, its biological function unclear progression. current research, we found was obviously elevated NSCLC tissues cells. Functional assays showed inhibition able...
Esophageal microbiota plays important roles in esophageal cancer. Esophagectomy, as the most therapeutic way, contributes to changes of microbiome. However, there are few studies examining microbiome and metabolic before after esophagectomy. The present study characterized 17 patients with squamous cell carcinoma (ESCC), 11 esophagogastric junction (EGJ) cancer, 15 at 9–12 months radical esophagectomy 16 healthy controls (HC). 16S ribosomal RNA gene sequencing was used evaluate predict...
Abstract Background Bone marrow-derived mesenchymal stem cells (MSCs), which possess immunomodulatory characteristic, are promising candidates for the treatment of acute myocardial infarction (AMI). However, low retention and survival rate MSCs in ischemic heart limit their therapeutic efficacy. Strategies either modifying or alleviating inflammatory environment, facilitates recruitment engrafted MSCs, may solve problem. Thus, we aimed to explore efficacy sequential transplantation exosomes...
Background: Lymphoepithelioma-like carcinoma (LELC) is a rare form of non-small cell lung carcinoma. The current study focused on its clinicopathological features and potential factors influencing the prognosis. Methods: statistical analysis was based records prognosis 43 LELC patients, analyzed by Kaplan-Meier method, Log-rank test, COX regression analysis. Results: patients' average age 57.35±9.22 years, 86.05% them were non-smokers 53.49% women. tumor diameter 3.24±1.57 cm. 2- 5-year...
Abstract Acute lung injury (ALI) induced by sepsis is characterized an inflammatory process related to the up‐regulation of cytokines and chemokines. In present study, we explored role circC3P1 in sepsis‐induced ALI vitro vivo. The caecal ligation puncture (CLP)‐induced model was established through CLP surgery. Forty adult male C57BL/6 mice were randomly assigned into sham, CLP, + vector (each n = 10). Primary murine pulmonary microvascular endothelial cells (MPVECs) transfected with or...
Abstract Long intergenic nonprotein coding RNA p53‐induced transcript (LINC‐PINT) has been reported to participate in various cancers. Here, we investigated the effects of LINC‐PINT on lung cancer progression. Firstly, our study, implied that was obviously decreased NSCLC. Thereafter, A549 and H1299 cells, upregulated via transfecting LV‐LINC‐PINT. As exhibited, repressed cell proliferation colony formation cells. Subsequently, flow cytometry evidenced apoptosis triggered cycle arrested G1...
Abstract Background Heart failure, which is characterized by cardiac remodelling, one of the most common chronic diseases in aged. Stimulator interferon genes (STING) acts as an indispensable molecule modulating immune response and inflammation many diseases. However, effects STING on cardiomyopathy, especially remodelling are still largely unknown. This study was designed to investigate whether could affect explore potential mechanisms. Methods In vivo , aortic binding (AB) surgery...
Abstract Therapeutic blockade of the immune checkpoint proteins programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has transformed cancer treatment. However, overall response rate to these treatments is low, suggesting that activation not only mechanism leading dysfunctional anti-tumour immunity. Here we show butyrophilin-like 2 (BTNL2) a potent suppressor response. Antibody-mediated BTNL2 attenuates tumour progression in multiple vivo murine models,...
Object: To detect expression of hypoxia inducible factor-<TEX>$1{\alpha}$</TEX> (HIF-<TEX>$1{\alpha}$</TEX>) and lysyl oxidase (LOX) in non-small cell lung cancer (NSCLC) explore their roles prognosis. Methods: The mRNA levels HIF-<TEX>$1{\alpha}$</TEX> LOX were investigated by real-time reverse-transcriptase polymerase chain reaction 40 cases tumour paired normal tissues. In addition, protein was examined immunohistochemistry 82 45 relationship between or clinicopathologic characteristics,...
Abstract Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) an important enzyme that regulates protein stability by modulating the acetylation level of non-histones. Here, we aimed to explore potential role and regulatory mechanisms HDAC3 PF. Methods We quantified expression both lung tissues from patients PF bleomycin (BLM)-treated mice. was also detected...