A5037330818- Invertebrate Immune Response Mechanisms
- Mosquito-borne diseases and control
- Aquaculture disease management and microbiota
- interferon and immune responses
- Insect symbiosis and bacterial influences
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Parkinson's Disease Mechanisms and Treatments
- Connective tissue disorders research
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Diverse Scientific Research Studies
- Transgenic Plants and Applications
- Cystic Fibrosis Research Advances
Shandong University
2023-2025
Huazhong University of Science and Technology
2020-2024
University of Electronic Science and Technology of China
2024
Anhui Medical University
2023
Shantou University
2014-2021
The successive emergences and accelerating spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages evolved resistance to some ongoing clinical therapeutics increase the risks associated with disease 2019 (COVID-19) pandemic. An urgent intervention for broadly effective therapies limit morbidity mortality COVID-19 future transmission events from SARS-related coronaviruses (SARSr-CoVs) is needed. Here, we isolate humanize an angiotensin-converting enzyme-2...
Although genome-wide association studies have identified the gene RNF186 encoding an E3 ubiquitin-protein ligase as conferring susceptibility to ulcerative colitis, exact function of this protein remains unclear. In present study, we demonstrate important role for in macroautophagy/autophagy activation colonic epithelial cells and intestinal homeostasis. Mechanistically, acts EPHB2 regulates ubiquitination EPHB2. Upon stimulation by ligand EFNB1 (ephrin B1), is ubiquitinated at Lys892,...
Abstract Myddosome is an oligomeric complex required for the transmission of inflammatory signals from TLR/IL1Rs and consists MyD88 IRAK family kinases. However, molecular basis self-assemble proteins regulation intracellular signaling remains poorly understood. Here, we identify OTUD5 acts as essential regulator oligomerization formation. directly interacts with cleaves its K11-linked polyubiquitin chains at Lys95, Lys231 Lys250. This cleavage enhances after LPS stimulation, which...
The TAGAP gene locus has been linked to several infectious diseases or autoimmune diseases, including candidemia and multiple sclerosis. While previous studies have described a role of in T cells, much less is known about its function other cell types. Here we report that required for Dectin-induced anti-fungal signaling proinflammatory cytokine production myeloid cells. Following stimulation with Dectin ligands, phosphorylated by EPHB2 at tyrosine 310, which bridges proximal activity...
Abstract Therapeutic blockade of the immune checkpoint proteins programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has transformed cancer treatment. However, overall response rate to these treatments is low, suggesting that activation not only mechanism leading dysfunctional anti-tumour immunity. Here we show butyrophilin-like 2 (BTNL2) a potent suppressor response. Antibody-mediated BTNL2 attenuates tumour progression in multiple vivo murine models,...
Background Mud crab Scylla paramamosain is an economically important marine species in China. However, frequent outbreaks of infectious diseases caused by bacteria, such as Vibrio parahaemolyticus, result great economic losses. Methodology/Principal Findings Comparative de novo transcriptome analysis S. infected with V. parahaemolyticus was carried out to investigate the molecular mechanisms underlying immune response pathogenic bacteria using Illumina paired-end sequencing platform. A total...
It is well known that exosomes could serve as anti-microbial immune factors in animals. However, despite growing evidences have shown the homeostasis of hemolymph microbiota was vital for regulation crustaceans, relationship between and during pathogenic bacteria infection has not been addressed. Here, we reported released from Vibrio parahaemolyticus -infected mud crabs ( Scylla paramamosain ) help to maintain a protective effect on mortality host process. We further confirmed miR-224...
Significance Each year, the global mortality rates for fungal diseases now exceed those malaria and breast cancer are currently comparable to tuberculosis HIV. The limited scope of available antifungal drugs is major factor underlying observed high rate. Here, we provide evidence that Myosin IF (MYO1F) plays a critical role in mediating signaling molecules “trafficking from membrane cytoplasm,” this process essential pathway activation. Moreover, Sirt2 deacetylase inhibitors promote immunity...
Abstract IL-17A plays an essential role in the pathogenesis of many autoimmune diseases, including psoriasis and multiple sclerosis. Act1 is a critical adaptor signaling pathway. In this study, we report that anti-sense long noncoding RNA, TRAF3IP2-AS1, regulates expression by recruiting SRSF10, which downregulates IRF1, transcriptional factor Act1. Interestingly, found psoriasis-susceptible variant TRAF3IP2-AS1 A4165G (rs13210247) gain-of-function mutant. Furthermore, identified mouse gene...
Fungal infections have emerged as a major concern among immunocompromised patients, causing approximately 2 million deaths each year worldwide. However, the regulatory mechanisms underlying antifungal immunity remain elusive and require further investigation. The E3 ligase Trim26 belongs to tripartite motif (Trim) protein family, which is involved in various biological processes, including cell proliferation, antiviral innate immunity, inflammatory responses. Herein, we report that exerts...
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of abnormal α-synuclein (α-syn) within dopaminergic neurons in substantia nigra region brain. Despite excessive α-syn being key to pathogenesis PD, mechanisms governing its clearance remain elusive. In this study, we found that endosomal sorting complex required for transport (ESCRT) system plays crucial role capturing and facilitating degradation ubiquitinated α-syn. The E3 ubiquitin...
The enzyme cyclic GMP-AMP synthase (cGAS) is a key sensor for detecting misplaced double-stranded DNA (dsDNA) of genomic, mitochondrial, and microbial origin. It synthesizes 2′3′-cGAMP, which in turn activates the stimulator interferon genes pathway, leading to initiation innate immune responses. Here, we identified Listerin as negative regulator cGAS-mediated response. We found that interacts with cGAS on endosomes promotes its K63-linked ubiquitination through recruitment E3 ligase TRIM27....
Invasive fungal infections have become a leading cause of death among immunocompromised patients, to around 1.5 million deaths per year globally. The molecular mechanisms by which hosts defend themselves against infection remain largely unclear, impedes the development antifungal drugs and other treatment options. In this article, we show that tyrosine kinase receptor EPH B2 (EPHB2), together with dectin-1, recognizes β-glucan activates downstream signaling pathways. Mechanistically, found...