A5074051355- Acute Myeloid Leukemia Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Drug Transport and Resistance Mechanisms
- Renal Transplantation Outcomes and Treatments
- Gastric Cancer Management and Outcomes
- Cancer therapeutics and mechanisms
- Acupuncture Treatment Research Studies
- Quinazolinone synthesis and applications
- Gastrointestinal Tumor Research and Treatment
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- Pharmacological Effects and Toxicity Studies
- Synthesis and Biological Evaluation
- Chronic Lymphocytic Leukemia Research
- Molecular Biology Techniques and Applications
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Renal Diseases and Glomerulopathies
- Mast cells and histamine
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
Nanchang University
2015-2025
First Affiliated Hospital of Nanchang University
2015-2025
First Affiliated Hospital of Jiangxi Medical College
2024
Wuhan University
2021-2024
Zhongnan Hospital of Wuhan University
2021-2024
Soochow University
2020-2024
Second Affiliated Hospital of Soochow University
2020-2024
Xuzhou No.1 People's Hospital
2023
Xuzhou Medical College
2023
Kiel University
2023
Abstract Minimally invasive thermal therapy is a successful alternative treatment to surgery in solid tumors with high complete ablation rates, however, tumor recurrence remains concern. Central memory CD8 + T cells (T CM ) play important roles protection from chronic infection and cancer. Here we find, by single-cell RNA analysis of human breast cancer samples, that although the phenotype peripheral increases slightly after microwave (MWA), metabolism unfavorable for phenotype. In mouse...
Cell-free DNA (cfDNA), a burgeoning class of molecular biomarkers, has been extensively studied across variety biomedical fields. As key component liquid biopsy, cfDNA testing is gaining prominence in disease detection and management due to the convenience sample collection abundant wealth genetic information it provides. However, broader clinical application currently impeded by lack standardization preanalytical procedures for analysis. A number fundamental challenges, including selection...
In the passive Heymann nephritis (PHN) model of membranous nephropathy, complement C5b-9 induces glomerular epithelial cell (GEC) injury, proteinuria, and activation cytosolic phospholipase A(2) (cPLA(2)). This study addresses role endoplasmic reticulum (ER) stress proteins (bip, grp94) in GEC injury. that overexpress cPLA(2) (produced by transfection) "neo" (which expresses at a lower level) were incubated with (40 min), leakage constitutively expressed bip grp94 from ER into cytosol was...
Mesenchymal stem cells (MSCs) are an attractive candidate for cell-based therapy. We have designed a promising double-target therapeutic system non-Hodgkin's lymphoma (NHL) The is based on MSC homing capacity and scFvCD20 antigen-restriction to NHL. In this system, novel secreted fusion protein scFvCD20-sTRAIL, which contains CD20-specific single chain Fv antibody fragment (scFv) soluble tumor necrosis factor related apoptosis-inducing ligand (sTRAIL, aa residues 114-281) with isoleucine...
Tacrolimus (TAC) is a first-line immunosuppressant which used to prevent transplant rejection after solid organ transplantation (SOT). However, it has narrow therapeutic index and high individual variability in pharmacokinetics (PK) pharmacogenomics (PG). It been reported that the metabolism of TAC can be affected by genetic factors, leading different rates subjects. Wuzhi Capsule (WZC) commonly TAC-sparing agent Chinese SOT reduce dosing due its inhibitory effect on enzymes CYP3A subfamily....
Multidrug resistance (MDR) is a major hurdle in the treatment of cancer. Research indicated that main mechanisms most cancers included so-called "pump" (P-glycoprotein, P-gp) and "non-pump" (apoptosis) resistance. Identification novel signaling molecules associated with both P-gp apoptosis will facilitate development more effective strategies to overcome MDR tumor cells. Since proto-oncogene c-fos has been implicated cell adaptation environmental changes, we analyzed its role mediating...
In this study, high performance hydrogels with strong underwater adhesion were constructed through a "mussel feet-rock" inspired strategy, in which random copolymer containing side-chain positive charges and catechol groups (PMD) simulated the adhesive proteins of mussel, poly(acrylic acid) (PAA) mimicked rocky surface. PMD PAA chains could noncovalently cross-link together hydrogen bonding, charge interaction, chain entanglement. Catechol further provide hydrogel ability. Taking advantage...
Objective: The introduction of Bruton's tyrosine kinase (BTK) inhibitors was a milestone in the treatment B-cell malignancies recent years owing to its desired efficacy against chronic lymphocytic leukaemia and small cell lymphoma. However, safety issues have hindered application clinical practice. current study aimed explore warning signals BTK real-world setting using FDA Adverse Event Reporting System (FAERS) provide reference for rational drug use. Methods: Owing short marketing time...
Introduction: Acute myeloid leukemia is characterized by high heterogeneity, and the current European Leukemia Net (ELN) risk stratification system not universally applicable to all AML patients, requiring approximately three weeks for testing. Aim: This study aimed develop an prognostic tool capable of addressing limitations methods. We selected patients from clinic TCGA database explore role ER stress in response chemotherapy. Methods: Patients were employed as training cohort, two GEO...
Abstract In the rat passive Heymann nephritis model of membranous nephropathy, complement C5b-9 induces sublethal glomerular epithelial cell (GEC) injury and proteinuria. activates cytosolic phospholipase A2 (cPLA2), products cPLA2-mediated phospholipid hydrolysis modulate GEC present study, we demonstrate that c-Jun N-terminal kinase (JNK) in cultured GECs JNK activity is increased glomeruli isolated from proteinuric rats with nephritis, as compared control rats. Stable overexpression cPLA2...
Neuroblastoma is a common solid malignant tumor of the sympathetic nervous system, which contributes to 15% cancer‑related mortality in children. The differentiation status neuroblastoma correlated with clinical outcome, and induction thus constitutes therapeutic approach this disease. However, molecular mechanisms that control remain poorly understood. present study aimed define whether GATA3 involved cells. results demonstrated prognostic marker for survival patients neuroblastoma,...
Cardiac adverse events (AEs) are common in tyrosine kinase inhibitors(TKIs). This study explored the cardiac AEs of TKIs through Food and Drug Administration's Adverse Event Reporting System (FAERS).
Studies have reported that electroacupuncture (EA) may reduce learning and memory impairment following cerebral ischemic injury. However, the precise mechanism of action remains unclear. In present study, attenuation focal ischemia/reperfusion injury by EA in rats was investigated. at Baihui (DU 20) Shenting 24) acupoints demonstrated to significantly improve performance Morris water maze task, with shortened latency time increased frequency passing platform. Molecular analysis revealed...
A previous study by our group found that electro-acupuncture (EA) at the Shenting (DU24) and Baihui (DU20) acupoints ameliorates cognitive impairment in rats with cerebral ischemia-reperfusion (I/R) injury. However, precise mechanism of action has remained largely unknown. The present investigated whether brain-derived neurotropic factor (BDNF) mediates hippocampal synaptic plasticity as underlying mechanism. Rats were randomly divided into three groups: sham operation control (Sham) group,...
To develop a population pharmacokinetic (PK) model of tacrolimus in Chinese Han renal transplant and establish the influence different covariates (especially CYP3A5/3A4/POR genotype) on PK properties. Trough concentrations, clinical characteristics CYP3A5/CYP3A4/POR genotypes were collected from 141 adult recipients after transplantation. The analysis was carried out using nonlinear mixed-effect modeling software NONMEM version 3.4.2. Tacrolimus profiles exhibited high interpatient...
A novel type of bone cement, magnesium potassium phosphate cement (MKPC), was fabricated by mixing 5% phosphoric acid with magnesia, dihydrogen phosphate, sucrose, hydroxyapatite, and sodium tri-polyphosphate powders. The surface morphology mechanical strength MKPC were investigated together tissue responses following implantation into rabbit condylar defects, using commercially available calcium (CPC) as the control. results showed that had a higher compressive (25.40 ± 0.61 MPa) than CPC...