A5100776628- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Hedgehog Signaling Pathway Studies
- Fungal Biology and Applications
- Epigenetics and DNA Methylation
- Advanced X-ray Imaging Techniques
- Cancer and Skin Lesions
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- Genetics, Aging, and Longevity in Model Organisms
- Plant Molecular Biology Research
- Cancer therapeutics and mechanisms
- Genetic and rare skin diseases.
- Hydrogels: synthesis, properties, applications
- Cutaneous lymphoproliferative disorders research
- Oral and Maxillofacial Pathology
- interferon and immune responses
- Medical Imaging Techniques and Applications
- Insect Resistance and Genetics
- Insect and Arachnid Ecology and Behavior
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
South China Agricultural University
2022-2025
Daqing Oilfield General Hospital
2024
Changzhou Third People's Hospital
2024
First Affiliated Hospital of GuangXi Medical University
2021-2023
Guangxi Medical University
2021-2023
Molecular Biology Consortium
2023
Industrial Technology Research Institute
2022
Key Laboratory of Guangdong Province
2022
Yunnan Normal University
2006-2021
University of Michigan
2003-2021
Nonselective inhibitors of human histone deacetylases (HDAC) are known to have antitumor activity in mice vivo, and several them under clinical investigation. The first these, Vorinostat (SAHA), has been approved for treatment cutaneous T-cell lymphoma. Questions remain concerning which HDAC isotype(s) the best target anticancer whether increased efficacy safety will result with an isotype-selective inhibitor. We developed inhibitor, MGCD0103, potently targets HDAC1 but also inhibitory...
Temporally and spatially constrained Hedgehog (Hh) signaling regulates cyclic growth of hair follicle epithelium while constitutive Hh drives the development basal cell carcinomas (BCCs), most common cancers in humans. Using mice engineered to conditionally express effector Gli2, we show that continued is required for established BCCs. Transgene inactivation led BCC regression accompanied by reduced tumor proliferation increased apoptosis, leaving behind a small subset nonproliferative cells...
Significant effort is being made to understand the role of HDAC isotypes in human cancer and develop antitumor agents with better therapeutic windows. A part this endeavor was exploration 14 internal cavity adjacent enzyme catalytic site, which led design synthesis compound 4 unusual bis(aryl)-type pharmacophore. SAR studies around lead resulted optimization potent, selective, nonhydroxamic acid inhibitors.
Long noncoding RNAs (lncRNAs) have recently received wide attention as key molecules that mediate a variety of physiological and pathological processes by regulating gene expression; however, knowledge lncRNAs in rheumatoid arthritis (RA) is limited. Thus, we investigated the lncRNA expression profile fibroblast-like synoviocytes (FLSs) from patients with RA explored function abundantly expressed lncRNAs. LncRNA mRNA microarrays were performed to identify differentially FLSs compared normal...
In the passive Heymann nephritis (PHN) model of membranous nephropathy, complement C5b-9 induces glomerular epithelial cell (GEC) injury, proteinuria, and activation cytosolic phospholipase A(2) (cPLA(2)). This study addresses role endoplasmic reticulum (ER) stress proteins (bip, grp94) in GEC injury. that overexpress cPLA(2) (produced by transfection) "neo" (which expresses at a lower level) were incubated with (40 min), leakage constitutively expressed bip grp94 from ER into cytosol was...
Ferroptosis, a defensive strategy commonly employed by the host cells to restrict pathogenic infections, has been implicated in development and therapeutic responses of various types cancer. However, role ferroptosis oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV)-induced cancers remains elusive. While growing number non-histone proteins have identified as acetylation targets, functions these modifications yet be revealed. Here, we show KSHV reprogramming proteomics following...
Inappropriate Hedgehog (Hh) signaling underlies development of a subset medulloblastomas, and tumors with elevated HH activity express the stem cell self-renewal gene BMI1. To test whether Bmi1 is required for Hh-driven medulloblastoma development, we varied dosage in transgenic mice expressing an oncogenic Hh effector, SmoA1, driven by glial fibrillary acidic protein (GFAP) promoter. Whereas 100% SmoA1; Bmi1+/+ or SmoA1;Bmi1+/- examined between postnatal (P) days 14 26 had typical...
Neuroblasts generate neurons with different functions by asymmetric cell division, cycle exit and differentiation. The underlying transcriptional regulatory pathways remain elusive. Here, we performed genetic screens in C. elegans identified three evolutionarily conserved transcription factors (TFs) essential for Q neuroblast lineage progression. Through live imaging analysis, showed that the storkhead TF HAM-1 regulates spindle positioning myosin polarization during division PAR-1-like...
Abstract RNAi is an effective tool for gene function analysis and a promising strategy to provide environmentally friendly control approaches pathogens pests. Recent studies support the utility of bacterium-mediated as cost-effective method study suitable externally applied delivery mechanism pest control. Here, we developed system in Spodoptera frugiperda based on four target genes, specifically, Chitinase (Sf-CHI), Chitin synthase B (Sf-CHSB), Sugar transporter SWEET1 (Sf-ST), Hemolin...
Abstract Background Emerging reports demonstrated that PIWI‐interacting RNAs (piRNAs) played an indispensable role in tumorigenesis. However, it still remains elusive whether piR‐1245 gastric juice specific stomach could be employed as a biomarker for cancer (GC). The present work is aiming at exploring the possibility of potential marker to judge diagnosis and prognosis cancer. Methods Gastric was collected from 66 GC patients healthy individuals. Quantitative real‐time reverse...
CRISPR/Cas9-based cytosine base editors (CBEs) and adenine (ABEs) can efficiently mediate C-to-T/G-to-A A-to-G/T-to-C substitutions, respectively; however, achieving transversions (C-to-G/C-to-A A-to-T/A-to-C) is challenging has been rarely studied in plants. Here, we constructed new plant C-to-G (CGBEs) A-to-Y (T/C) explored their editing characteristics rice. First, fused the highly active cytidine deaminase evoFENRY PAM-relaxed Cas9-nickase variant Cas9n-NG with rice human uracil DNA...
SUMMARY The grains of rice ( Oryza sativa ) are enclosed by a spikelet hull comprising the lemma and palea. Development determines storage capacity grain, thus affecting grain yield quality. Although multiple signaling pathways controlling size have been identified, transcriptional regulatory mechanisms underlying development remain limited. Here, we used RNA‐seq ATAC‐seq to characterize transcription chromatin accessibility dynamics during hulls. A time‐course analysis showed that more than...
Soybean, as a major oil crop, is one of the most widely planted crops in world. Fusarium oxysporum causes soybean root rot, leading to great economic losses planting every year globally. Chemical fungicide for controlling F. diseases may cause environmental problems and has human health risks. Biological control methods avoid these shortcomings; however, few studies have focused on biocontrol caused by oxysporum. Aiming at this problem, we obtained bacteria against plate confrontation...
Plant height is an important agronomic trait for lodging resistance and yield. Here, we report a new plant-height-related gene, OsUBR7 in rice (Oryza sativa L.); knockout of caused fewer cells internodes, resulting semi-dwarf phenotype. encodes putative E3 ligase containing plant homeodomain finger ubiquitin protein component N-recognin 7 (UBR7) domain. interacts with histones monoubiquitinates H2B (H2Bub1) at lysine148 coordination the E2 conjugase OsUBC18. mediates H2Bub1 number chromatin...