A5100435388- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Issues in Pregnancy
- Health Systems, Economic Evaluations, Quality of Life
- Angiogenesis and VEGF in Cancer
- Sports injuries and prevention
- Aortic aneurysm repair treatments
- IL-33, ST2, and ILC Pathways
- Cardiovascular and exercise physiology
- Semiconductor materials and devices
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
Wuhan University
2015-2024
Wuhan Asia Heart Hospital
2015-2024
First Affiliated Hospital of Zhengzhou University
2009-2024
University of Maryland, Baltimore
2015-2024
Office of Chief Medical Examiner
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
State Key Laboratory of Cardiovascular Disease
2022
Beijing Anzhen Hospital
2022
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
Abstract Background Current studies suggest that cardiac troponin (cTn) forms in the circulation may vary different clinical scenarios. Our aim was to design a combination of cTn assays specific main and evaluate their analytical performance. Methods We developed immunoassays for measuring (1) long-cTnT cTnI-cTnT-TnC (ITC) ternary complex, with cTnT long form without cleavage at C-terminal amino acids residue 189–223, designated “long-cTnT ITC complex assay;” (2) both plus short-cTnT...
Abstract Background Registry studies in high‐income countries have defined contemporary management of heart failure (HF), but few such data exist the large aging population China. We report study design and baseline characteristics Heart Failure Patient Outcomes (HERO) study, undertaken to determine evidence–practice gaps HF a broad representative Methods results The HERO is prospective, longitudinal, seasonally‐rotating, multicentre registry patients hospitalized with acute who are followed...
Cardiac troponin (cTn) is the key biomarker for diagnosis of acute coronary syndrome (ACS). We performed a complete assessment high-sensitivity cardiac I (hs-cTnI) (CLIA) assay on analytical performance and clinical diagnostic performance, which was compared with Abbott ARCHITECT hs-cTnI assay.
Abstract Background Increased cardiac troponin (cTn) concentrations occur in acute myocardial injury and chronic diseases. Characterization of cTn composition the circulation may assist differentiating etiologies injury. Our goal was to study kinetics patients following type 1 infraction (T1MI), procedures, heart diseases establish relationship between clinical diagnosis. Methods Plasma samples were collected from 201 with T1MI, 78 undergoing surgeries, 218 cardiomyopathy or failure. Major...
Soluble suppression of tumorigenicity 2 (sST2), a biomarker representing myocardial fibrosis and inflammation, has been applied in risk stratification patients with infarction (MI). However, whether primary PCI (PPCI) will eliminate the predictive value sST2 STEMI not well studied. Here, we conducted prospective clinical trial to evaluate correlation between prognosis undergoing PPCI. levels were measured 295 (60.2 ± 10.8 years) at admission using high sensitivity assay. Baseline...
Abstract Background Data on fibrinolytic therapy use for ST-segment elevation myocardial infarction (STEMI) and long-term clinical outcomes in developing countries are limited. We aimed to investigate the management 2-year mortality of fibrinolytic-treated patients China. Methods A total 19,112 with STEMI from 108 hospitals participated China Acute Myocardial Infarction registry between January 2013 September 2014. investigated all-cause among treated fibrinolysis. Non-invasive indexes were...
Abstract Background There is great heterogeneity in the quality of care among hospitals China, but studies on performance measures and prognosis patients with heart failure (HF) are still deficient. Hypothesis Performance have been used as a guideline to clinicans, however, association between them outcomes HF China remains unclear. Methods We analyzed 4497 from Heart Failure Registry Patient Outcomes study. were determined according guidelines, divided into four groups based composite...
Abstract Objectives The N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) is a widely used heart failure (HF) biomarker. Commercial NT-proBNP immunoassays detect only subfraction endogenous NT-proBNP, as the antibodies target region that could be glycosylated at Ser44. diagnostic utility measuring total remains unclear. Methods was measured in 183 HF and 200 non-HF patients diagnosed by two independent cardiologists blinded to results. Plasma samples either non-treated or...
To investigate the relationship between serum plasma pregnancy-associated protein A (PAPP-A) and coronary plaque characteristics, their prognostic value for no-reflow after percutaneous intervention (PCI).Patients with unstable angina undergoing PCI were divided into a normal reflow group stent deployment. Coronary blood flow was measured angiographically; components detected by virtual histology intravascular ultrasound. Serum PAPP-A high-sensitivity C-reactive (hsCRP) before PCI. Cardiac...
Anemia is common in patients with chronic heart failure (HF) and associated adverse outcomes. However, data regarding the prognostic value of on-admission anemia on mortality hospitalized acute HF were relatively limited conflicting. This study aimed to investigate association 1-year evaluate whether an independent predictor HF.The present analysis included 4,244 from HERO (Heart Failure Registry Patient Outcomes) study. On-admission was defined using World Health Organization (WHO) criteria...
The aim of this study was to investigate whether the neuropeptide calcitonin gene related peptide (CGRP) contributes nitroglycerin (GTN) response in patients with chronic heart failure (CHF) and association mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism.This is a 2-period, placebo-controlled clinical study. An intravenous infusion saline followed by GTN (20 μg/min), each for 2 hours, respectively, given 49 stable CHF patients. Blood pressure (BP), rate (HR)...
SUMMARY Inhibiting the renin–angiotensin–aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). The present study was designed to assess effects of a combination perindopril and losartan on LV remodelling, cardiac function serum procollagen type III amino terminal peptide (PIIINP) levels in patients with acute MI. Patients anterior MI were divided into three groups: (i) + perindopril; (ii) losartan; (iii) losartan. After successful intervention...
Background Depression is a prevalent comorbidity in patients with heart failure (HF). However, data regarding the prognostic significance of depression during early post-discharge period hospitalized acute HF, regardless left ventricular ejection fraction (LVEF), were scarce. Methods and results The Heart Failure Registry Patient Outcomes (HERO) study prospective, multicenter HF China. At first follow-up after discharge (median 4.0, interquartile range [IQR]: 2.4–6.1 weeks), depressive...
Spontaneous coronary artery dissection occurs predominantly in women and is associated with fibromuscular dysplasia. We illustrate a rare case of sudden death as result cardiac rupture from spontaneous 54-year-old man without Cardiac has been previously reported 6 cases, mostly women.
We aimed to explore the association between stressful life events and coronary plaque vulnerability, examine moderating effects of psychological distress physiological indices. A total 311 patients with acute syndrome (ACS) completed Life Events Scale, Zung Self-Rating Depression Anxiety Scales. Plaque vulnerability was assessed by in vivo optical coherence tomography (OCT). The regression analysis showed that were independent predictors including lipid-rich (OR = 1.018, 95% CI 1.005, 1.031,...
Objective To study the thrombolysis effect and safety of UK combined with tirofiban in young patients ST segement elevation acute myocardial infarction. Methods 76 elvation infarction were selected as research objects,and they divided into group(control group,n= 34)and group(observation group,n=42)by random number table,then recanalization rate infarct-related artery incidence complications compared. Results The observation group was 97.6%,which 91.2%in control group,there no...
：Objective To explore therelationship between renal function and coronary heart disease(CHD) in patients withcoronary disease. Methods One hundred eighty -nine underwent coronaryangiography, according to different degrees of artery disease were divided intonormal control group the CHD (including single vessel disease, double vesseldisease,multi - disease), detected blood 132 microglobulin, urea nitrogen,creatinine concentration,and β2 ureanitrogen, differences creatinine concentration...
Background: Reperfusion evaluation after primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) remains challenging in clinical practice. We aimed to evaluate the long-term prognostic significance of resolution (STR) alone and combination with Thrombolysis Myocardial Infarction (TIMI) flow PPCI STEMI. Methods: analyzed relationship between STR from one lead showing most prominent ST at 120 min 2-year all-cause mortality 5966 patients STEMI...