A5019424924- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
- COVID-19 and healthcare impacts
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Obstructive Sleep Apnea Research
- Climate Change and Health Impacts
- Lung Cancer Diagnosis and Treatment
- Neurological disorders and treatments
- Sports injuries and prevention
- Hormonal Regulation and Hypertension
- Cardiovascular Issues in Pregnancy
- Nitric Oxide and Endothelin Effects
- Colorectal Cancer Treatments and Studies
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Heparin-Induced Thrombocytopenia and Thrombosis
Henan Provincial People's Hospital
2020-2025
Zhengzhou Central Hospital
2020-2025
Zhengzhou University
2023
Vifor Pharma (United States)
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2022
Academia Sinica
2022
Peking Union Medical College Hospital
2019
Fu Wai Hospital
2019
Background: Catheter ablation as first-line therapy for ventricular tachycardia (VT) at the time of implantable cardioverter defibrillator (ICD) implantation has not been adopted into clinical guidelines. Also, there is an unmet need to prospectively examine role VT in patients with nonischemic cardiomyopathy, increasingly prevalent population that referred advanced therapies globally. Methods: We conducted international, multicenter, randomized controlled trial enrolling 180 cardiomyopathy...
Objective: To examine whether spironolactone could reduce the severity of obstructive sleep apnea (OSA) and lower blood pressure in patients with resistant hypertension. Methods: This was a blank-controlled, single-center study. Patients hypertension moderate-to-severe OSA (apnea–hypopnea index >15 events/h) were enrolled randomly assigned to therapy or control group. group administered 20 mg once daily (up 40 for 4 weeks, if required) addition original antihypertensive medication. Follow-up...
Background: Increased parasympathetic activity is thought to play important roles in syncope events of patients with vasovagal (VVS). However, direct measurements the vagal control are difficult. The novel deceleration capacity (DC) heart rate measure has been used characterize modulation. This study aimed assess VVS and evaluate diagnostic value DC VVS. Methods: Altogether, 161 consecutive (43±15 years; 62 males) were enrolled. Tilt table test was positive 101 negative 60 patients....
Background: Circumferential pulmonary vein isolation (CPVI) often cause unavoidable vagal reflexes during procedure due to the coincidental modification of ganglionated plexus which are located on (PV) antrum. The right anterior plexi (RAGP) at superoanterior area superior PV antrum is an essential station regulate cardiac autonomic nerve activities and easily coincidentally ablated CPVI. aim this study assess effect RAGP ablation response (VR) Methods: A total 80 patients with paroxysmal...
The study aims to describe the long-term outcome of radiofrequency catheter ablation for ventricular tachycardia (VT) in a large cohort arrhythmogenic right cardiomyopathy (ARVC) patients.Radiofrequency was performed 284 ARVC patients due VT between July 2000 and January 2019. An endocardial approach used initially, with epicardial procedures reserved those who failed an ablation. Activation, entrainment, pace substrate mapping strategies were regional applied. A total 393 including only (n...
Abstract Aim To assess the electrocardiogram patterns of paced QRS narrowing after successful left bundle branch area pacing (LBBAP) and echocardiographic measurements in patients with bradycardia block (BBB). Methods We prospectively enrolled 55 consecutive BBB ventricular ejection fraction ≥40% who had attempted LBBAP. Successful LBBAP was defined as morphology a right (RBBB) pattern lead V1 recording abruptly shortened then constant stimulus to peak activation time high low output. Pacing...
Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim this study was to investigate the genetic susceptibility TA in Chinese population.Four single nucleotide polymorphisms (SNPs) those locate IL12B region (rs56167332), MLX (rs665268), FCGR2A/FCGR3A locus (rs10919543), and HLA-B/MICA (rs12524487), associated with different population, were genotyped 123 patients 147 healthy controls from January 2013 August 2014. A Chi-square test used for genotype/allele...
Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable myocardium disorder that predominantly affects the ventricle. Little known about atrial involvement. This study aimed to assess involvement, especially role of genotype on atrium in ARVC. Methods The incidence, characterization and predictors involvement were investigated. Nine ARVC‐causing genes screened correlation between was assessed. Results Right (RA) dilation, left (LA) sustained tachyarrhythmias...
Abstract Background Congenitally corrected transposition of great arteries (ccTGA) is a rare congenital cardiac defect with atrioventricular and ventriculoarterial discordance which leads to heart failure limits patients’ lifespan. The extremely aberrant structure makes electrophysiological procedure radiofrequency ablation very difficult be performed in such patients. Until now, there were only sporadical cases that have reported the successful atrial flutter ccTGA Case presentation We...
To investigate the long-term efficacy of continuous positive airway pressure (CPAP) treatment for patients with obstructive sleep apnea syndrome (OSAS).This case control study was performed among 154 moderate or severe OSAS between September 2009 and 2014. Patients were divided into group (n=66, 53 hypertension) (n=88, 67 hypertension). The CPAP on clinical events blood evaluated.The combined incidence death, myocardial infarction, coronary revascularization stroke 1.5% (1/66) in 11.4%...
The present study aimed to evaluate the safety and efficacy of an optimized single transseptal puncture technique contact force sensing atrial fibrillation (AF) radiofrequency catheter ablation (RFCA) strategy within a clinical setting. Fast anatomic mapping was applied patients with paroxysmal AF (PAF) between September 2014 December 2016 using trans-septal sheath. Pulmonary vein isolation (PVI) linear were performed in PAF individually 10-20 g minimal fluoroscopy. Stimulation 10 mA outputs...
Abstract Background Left bundle branch area pacing (LBBAP), lacks adequate evaluation for AVB. Purpose We aimed to assess the feasibility, safety, and acute clinical outcomes of permanent LBBAP in patients with Methods retrospectively recruited AVB indication ventricular who had underwent from May Sep. 2018. ECG characteristics, parameters, echocardiographic parameters adverse events were evaluated during follow-up. Successful was defined as paced QRS morphology RBBB pattern QRSd less than...
Endothelial function, as measured by big endothelin-1 (ET-1), has been demonstrated to be useful in predicting adverse long-term events patients with cardiovascular disease. Nevertheless, there are little data about the association between ET-1 and thromboembolism risk atrial fibrillation (AF). We aimed investigate relationship CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic non-valvular AF.The study population consisted of 238 consecutive AF (67.6% paroxysmal 32.4% persistent...