A5113677960- Antenna Design and Analysis
- T-cell and B-cell Immunology
- Advanced Antenna and Metasurface Technologies
- Air Quality and Health Impacts
- Microwave Engineering and Waveguides
- Electromagnetic Compatibility and Measurements
- Antenna Design and Optimization
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Genomics and Phylogenetic Studies
- Climate Change and Health Impacts
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Millimeter-Wave Propagation and Modeling
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Biomarkers in Disease Mechanisms
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- IPv6, Mobility, Handover, Networks, Security
- Gene expression and cancer classification
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
Harvard University
2014-2025
Zhengzhou Central Hospital
2024
First Affiliated Hospital of Anhui Medical University
2024
Henan Provincial People's Hospital
2024
Anhui Medical University
2024
Shenzhen University
2024
Capital Medical University
2019-2023
Wenzhou Medical University
2014-2022
First Affiliated Hospital of Wenzhou Medical University
2014-2022
Ericsson (Sweden)
2022
Gene Ontology (GO), the de facto standard in gene functionality description, is used widely functional annotation and enrichment analysis. Here, we introduce agriGO, an integrated web-based GO analysis toolkit for agricultural community, using advantages of our previous tool (EasyGO), to meet demands from new technologies research objectives. EasyGO valuable its proficiency, has proved useful uncovering biological knowledge massive data sets high-throughput experiments. For system...
The agriGO platform, which has been serving the scientific community for >10 years, specifically focuses on gene ontology (GO) enrichment analyses of plant and agricultural species. We continuously maintain update databases accommodate various requests our global users. Here, we present updated that a largely expanded number supporting species (394) datatypes (865). In addition, larger have classified into groups covering crops, vegetables, fish, birds insects closely related to community....
Abstract Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for binding to protein-coding transcripts. However, the prevalence, functional significance targets of lncRNA-mediated sponge regulation cancer are mostly unknown. Here we identify a regulatory network affects expression many prostate driver genes, by integrating analysis sequence features gene profiles both lncRNAs genes in tumours. We confirm tumour-suppressive two (TUG1...
Gene Set Enrichment Analysis (GSEA) is a powerful method for interpreting biological meaning of list genes by computing the overlaps with various previously defined gene sets. As one most widely used annotations defining sets, Ontology (GO) system has been in many enrichment analysis tools. EasyGO and agriGO, two GO toolkits developed our laboratory, have gained extensive usage citations since their releases because effective performance consistent maintenance. Responding to increasing...
Mitophagy is the process of selective mitochondrial degradation via autophagy, which has an important role in quality control. Very little known, however, about molecular mechanism mitophagy. A genome-wide yeast mutant screen for mitophagy-defective strains identified 32 mutants with a block mitophagy, addition to known autophagy-related (ATG) gene mutants. We further characterized one these mutants, ylr356wDelta that corresponds whose function not been identified. YLR356W mitophagy-specific...
Significance Our study provided a comprehensive view of the transcriptional landscape across cell cycle. We revealed lag between transcription and steady-state RNA expression at cell-cycle level characterized large amount active during early mitosis. In addition, our analysis identified thousands enhancer RNAs related factors that are highly correlated with cell-cycle–regulated but not expression, thus highlighting importance epigenetic dynamics progression.
Significance DNA double-strand breaks (DSBs) occur in all cells, including neural stem/progenitor cells (NSPCs) that give rise to the brain. We previously found developing lacking a major DSB end-joining pathway are subject widespread death. Because DSBs may result from gene transcription, we assayed for near active transcription start sites (TSSs) genome-wide NSPCs. TSSs of highly transcribed genes involved general cellular processes but less often neural-specific TSSs. These TSS-associated...
Short-term PM
Autophagy has been implicated in a number of physiological processes important for human heath and disease. involves the formation double-membrane cytosolic vesicle, an autophagosome. Central to autophagosome is ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated 1 light chain 3/LC3 mammalian cells). Following autophagy induction, Atg8 shows greatest change expression any proteins required autophagy. The magnitude is, part, controlled by amount Atg8; thus, controlling...
Significance B lymphocytes change the type of antibody they express to combat infections though a DNA breakage and joining process termed class switch recombination (CSR). During CSR, breaks are introduced into two specific regions locus, these joined make new form gene. Like other genomic breaks, CSR activate cellular damage response pathway that helps ensure their proper repair. We now show that, when certain components inactivated, B-cell junctions different molecular signatures,...
Significance Antibodies are generated by B cells of the adaptive immune system to eliminate various pathogens. A somatic gene rearrangement process, termed V(D)J recombination, assembles antibody segments form sequences encoding antigen-binding regions antibodies. Each multitude newly produces a different with unique sequence, which collectively primary repertoire an individual. Given utility specific antibodies for treating human diseases, approaches elucidate repertoires great importance....
Abstract Fine particulate matter (PM 2.5 ) exposure is correlated with the risk of developing cardiac fibrosis. Melatonin a major secretory product pineal gland that has been reported to prevent However, whether melatonin affects adverse health effects PM not investigated. Thus, this study was aimed investigate protective effect against ‐accelerated The echocardiography revealed had impaired both systolic and diastolic function in ApoE −/− mice. Histopathological analysis demonstrated...
Abstract Background The ubiquitin 26S/proteasome system (UPS), a serial cascade process of protein ubiquitination and degradation, is the last step for most cellular proteins. There are many genes involved in this system, but not identified species. accumulating availability genomic sequence data generating more demands management analysis. Genomics plants such as Populus trichocarpa , Medicago truncatula Glycine max others now publicly accessible. It time to integrate information on classes...
Abstract Glucose monitoring sensors with high softness and flexibility are critical for the developments of wearable implantable healthcare devices that enable diagnosis, prognosis, management diabetes. The design implementation such have been extensively exploited by electrochemical strategies, which, however, suffer from poor reusability complex modification procedures, necessitate frequent calibration or sensor replacement due to enzymatic reaction instability. Here, a soft plasmonic...