A5008474314- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Air Quality and Health Impacts
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Climate Change and Health Impacts
- Nanocluster Synthesis and Applications
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
- Sulfur Compounds in Biology
- Lanthanide and Transition Metal Complexes
- Air Quality Monitoring and Forecasting
- Advanced Photocatalysis Techniques
- Biomarkers in Disease Mechanisms
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Pickering emulsions and particle stabilization
- Immunotherapy and Immune Responses
- Supramolecular Self-Assembly in Materials
Fuzhou University
2014-2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Capital Medical University
2020-2024
Northeastern University
2024
Third Affiliated Hospital of Guangzhou Medical University
2019-2022
Guangzhou Medical University
2019-2022
Capital University
2022
National Institute of Biomedical Imaging and Bioengineering
2015-2020
National Institutes of Health
2015-2020
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for...
Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4@polydopamine core–shell (Fe3O4@PDA NCs) through an in situ self-polymerization method. Dopamine, melanin-like mimic of mussel adhesive proteins, can self-polymerize form surface-adherent polydopamine (PDA) films onto wide range materials including Fe3O4 nanoparticles used here. In such nanocomposites, PDA provides number...
Abstract Reactive oxygen species (ROS)‐induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal control ROS generation, meticulous participation light, photosensitizer, and greatly hinders broad application PDT as first‐line treatment option. An activatable system has been developed that enables tumor‐specific singlet ( 1 O 2 ) generation therapy, based on Fenton‐like reaction between linoleic acid...
It is essential to control the size and morphology of nanoparticles strictly in nanomedicine. Protein cages offer significant potential for templated synthesis inorganic nanoparticles. In this study, we successfully synthesized ultrasmall copper sulfide (CuS) inside cavity ferritin (Fn) nanocages by a biomimetic method. The uniform CuS–Fn (CuS–Fn NCs) showed strong near-infrared absorbance high photothermal conversion efficiency. quantitative ratiometric photoacoustic imaging (PAI), NCs...
We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic gold nanorod vesicle (rGO-AuNRVe) (∼65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The also exhibits high loading capacity of doxorubicin (DOX), as both the cavity large surface area encapsulated rGO can be used for DOX, making it an excellent drug carrier. loaded DOX is released sequentially: near-infrared heating induces release from vesicular cavity, intracellular...
Graphitic-phase carbon nitride (g-C3N4) nanosheets, the newly emerging two-dimensional (2D) layered nanomaterials, have been demonstrated to be promising bioimaging agents due their high photoluminescence (PL) quantum yields, good biocompatibility and low toxicity. However, therapeutic applications of g-C3N4 nanosheets not explored until now. In this study, we proven for first time that can used as efficient photosensitizers photodynamic tumor therapy pH-responsive nanocarriers drug...
Immunogenic cell death (ICD) elicited by photodynamic therapy (PDT) is mediated through generation of reactive oxygen species (ROS) that induce endoplasmic reticulum (ER) stress. However, the half-life ROS very short and intracellular diffusion depth limited, which impairs ER localization thus limits stress induction. To solve problem, we synthesized reduction-sensitive Ds-sP NPs (PEG-s-s-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] nanoparticles)...
A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG poly(ethylene glycol); PLGA poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion the body as AuNR@PEG after therapy; enhanced photoacoustic photo thermal properties; high photothermal cancer therapy efficacy.
The recently emerged exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) (<5 nm) are promising T1-weighted contrast agents for resonance imaging (MRI) due to their good biocompatibility compared with Gd-chelates. However, the best particle size of ES-MIONs T1 is still unknown because synthesis precise control clarify relationship between r1 (or r2/r1) and remains a challenge. In this study, we synthesized seven different sizes below 5 nm found that 3.6 be utilized as MR agent. To...
Combination therapy that could better balance immune activation and suppressive signals holds great potential in cancer immunotherapy. Herein, we serendipitously found the pH-responsive nanovesicles (pRNVs) self-assembled from block copolymer polyethylene glycol-b-cationic polypeptide can not only serve as a nanocarrier but also cause immunogenic cell death (ICD) through preapoptotic exposure of calreticulin. After coencapsulation photosensitizer, 2-(1-hexyloxyethyl)-2-devinyl...
Abstract Tumor‐lymph node (LN) metastasis is the dominant prognostic factor for tumor staging and therapeutic decision‐making. However, concurrently visualizing performing imaging‐guided lymph surgery challenging. Here, a multiplexed‐near‐infrared‐II (NIR‐II) in vivo imaging system using nonoverlapping NIR‐II probes with markedly suppressed photon scattering zero‐autofluorescence reported, which enables visualization of metastatic proximal LNs resection. A bright tumor‐seeking...
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However, administration an excess amount exogenous Fenton-type heavy metals may cause potential adverse effects human health, including acute and chronic damages. Here, we present a new CDT strategy that uses intracellular labile iron pool (LIP) as endogenous source Fenton-reactive for eliciting free generation,...
Immunomodulation of macrophages against cancer has emerged as an encouraging therapeutic strategy. However, there exist two major challenges in effectively activating for antitumor immunotherapy. First, ligation signal regulatory protein alpha (SIRPα) on to CD47, a "don't eat me" cells, prevents macrophage phagocytosis cells. Second, colony stimulating factors, secreted by polarize tumor-associated (TAMs) tumorigenic M2 phenotype. Here, it is reported that genetically engineered...
A cancer vaccine is an important form of immunotherapy. Given their effectiveness for antigen processing and presentation, dendritic cells (DCs) have been exploited in the development a therapeutic vaccine. Herein, versatile polymersomal nanoformulation that enables generation tumor-associated antigens (TAAs) simultaneously serves as adjuvant situ DC reported. The chimeric cross-linked polymersome (CCPS) acquired from self-assembly triblock copolymer, polyethylene glycol-poly(methyl...
Abstract Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened by elevated reactive oxygen species (ROS) in the tumour microenvironment. It is therefore of critical importance to modulate level extracellular ROS for reversal immunosuppressive environment. Here, we present a matrix (ECM) targeting nanoscavenger masked pH sensitive covalently crosslinked polyethylene glycol. The anchors on ECM sweep away from microenvironment relieve ICD elicited specific...
Abstract Cell membrane coating nanotechnology, which endows nanoparticles with unique properties, displays excellent translational potential in cancer diagnosis and therapy. However, the preparation evaluation of these cell membrane‐coated are based on lines cell‐line‐based xenograft mouse models. The feasibility membrane‐camouflaged nanomaterials is tested a preclinical setting. Head neck squamous carcinoma (HNSCC) patient‐derived tumor (PDTC) membranes coated onto gelatin (GNPs) resulting...
Abstract Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there no study exploring effect cell membrane unsaturation degree on CDT. Here, we report a self‐reinforcing CDT agent (denoted as OA@Fe‐SAC@EM NPs), consisting oleanolic acid (OA)‐loaded iron single‐atom catalyst (Fe‐SAC)‐embedded hollow carbon...
As a rising generation of nanozymes, single atom enzymes show significant promise for cancer therapy, due to their maximum utilization efficiency and well-defined electronic structures. However, it remains tremendous challenge precisely produce heteroatom-doped enzyme with an expected coordination environment. Herein, we develop anion exchange strategy controlled production edge-rich sulfur (S)- nitrogen (N)-decorated nickel (S-N/Ni PSAE). In particular, sulfurized S-N/Ni PSAE exhibits...
Tumor-specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)-responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) rationally designed. The acidic TME could drive self-assembly SPB@POM into bigger aggregates for enhanced retention accumulation, while reducing significantly enhance NIR absorption significant improvement photoacoustic imaging...