A5081891353- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Advancements in Solid Oxide Fuel Cells
- Magnetic and transport properties of perovskites and related materials
- Electronic and Structural Properties of Oxides
- Photoacoustic and Ultrasonic Imaging
- Conducting polymers and applications
- Acoustic Wave Phenomena Research
- Cancer, Hypoxia, and Metabolism
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Photocatalysis Techniques
- Sulfur Compounds in Biology
- Extracellular vesicles in disease
- Chemical Synthesis and Characterization
- Noise Effects and Management
- Molecular Sensors and Ion Detection
- Perovskite Materials and Applications
- Extraction and Separation Processes
- Gold and Silver Nanoparticles Synthesis and Applications
- Adsorption and biosorption for pollutant removal
- Multiferroics and related materials
Fujian Normal University
2021-2025
Jinan Maternity And Care Hospital
2025
University of Jinan
2017-2025
Affiliated Hospital of North Sichuan Medical College
2025
Bioscience (China)
2025
East China University of Science and Technology
2008-2024
Moderna Therapeutics (United States)
2024
North China Electric Power University
2022-2024
China Electric Power Research Institute
2022-2024
Xiangtan University
2019-2023
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
Abstract Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)‐assisted conversion of into gluconic acid toxic H 2 O , novel treatment paradigm starving‐like therapy developed significant tumor‐killing effects, more effective than conventional starving only cutting off supply. Furthermore, generated acidic can oxidize l ‐Arginine ( ‐Arg) NO enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as...
Cancer is one of the leading causes morbidity and mortality in world, but more cancer therapies are needed to complement existing regimens due problems therapies. Herein, we term ferroptosis therapy (FT) as a form hypothesize that FT efficacy can be significantly improved via accelerating Fenton reaction by simultaneously increasing local concentrations all reactants (Fe2+, Fe3+, H2O2) cells. Thus, Fenton-reaction-acceleratable magnetic nanoparticles, i.e., cisplatin (CDDP)-loaded...
Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via biocompatible metal-polyphenol networks self-assembly process by encapsulating doxorubicin (DOX) platinum prodrugs in nanoparticles. Both DOX drugs can activate nicotinamide adenine dinucleotide phosphate oxidases, generating superoxide...
Abstract Reactive oxygen species (ROS)‐induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal control ROS generation, meticulous participation light, photosensitizer, and greatly hinders broad application PDT as first‐line treatment option. An activatable system has been developed that enables tumor‐specific singlet ( 1 O 2 ) generation therapy, based on Fenton‐like reaction between linoleic acid...
In order to promote preclinical and clinical applications of photoacoustic imaging, novel contrast agents are highly desired for molecular imaging diseases, especially deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles reported as an efficient agent brain tumors in living mice with enhanced permeability retention effect.
Biocatalytic reactions in living cells involve complex transformations the spatially confined microenvironments. Inspired by biological transformation processes, we demonstrate effective biocatalytic cascade driven photodynamic therapy tumor-bearing mice integration of an artificial enzyme (ultrasmall Au nanoparticles) with upconversion nanoparticles (NaYF4@NaYb0.92F4:Er0.08@NaYF4)zirconium/iron porphyrin metal-organic framework core-shell (UMOF NPs) which act as biocatalysts and...
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
The development of smart theranostic systems with favourable biocompatibility, high loading efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal diagnostic functionalities is importance for future clinical application. premature burst release poor degradation kinetics indicative polymer-based nanomedicines remain the major obstacles translation. Herein we prepare shell-crosslinked nanoparticles (SCNPs) using a β-cyclodextrin-based polyrotaxane...
Immunomodulation of macrophages against cancer has emerged as an encouraging therapeutic strategy. However, there exist two major challenges in effectively activating for antitumor immunotherapy. First, ligation signal regulatory protein alpha (SIRPα) on to CD47, a "don't eat me" cells, prevents macrophage phagocytosis cells. Second, colony stimulating factors, secreted by polarize tumor-associated (TAMs) tumorigenic M2 phenotype. Here, it is reported that genetically engineered...
A cancer vaccine is an important form of immunotherapy. Given their effectiveness for antigen processing and presentation, dendritic cells (DCs) have been exploited in the development a therapeutic vaccine. Herein, versatile polymersomal nanoformulation that enables generation tumor-associated antigens (TAAs) simultaneously serves as adjuvant situ DC reported. The chimeric cross-linked polymersome (CCPS) acquired from self-assembly triblock copolymer, polyethylene glycol-poly(methyl...
The combination of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhancing ROS-mediated cancer treatment. Herein, we reported an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor to integrate the synergistic effect PDT/CDT pancreatic ductal adenocarcinoma HPPH photosensitizer was hybridized within framework HMON via "in growth" approach. Then, cavity HMONs exploited as a...
Combination of photoacoustic (PA) and ultrasound (US) imaging offers high spatial resolution images with deep tissue penetration, which shows great potential in applications medical imaging. Development PA/US dual-contrast agents contrast excellent biocompatibility is interest. Herein, an organic semiconducting nanodroplet, PS-PDI-PAnD, developed by stabilizing low-boiling-point perfluorocarbon (PFC) droplet a photoabsorber agent perylene diimide (PDI) molecules coencapsulating the...
Abstract Enhancing the generation of reactive oxygen species (ROS) is an effective anticancer strategy. However, it a great challenge to control production and image ROS in vivo, both which are vital for improving efficacy accuracy cancer therapy. Herein, activatable semiconducting theranostic nanoparticle (NP) platform developed that can simultaneously enhance while self‐monitoring its levels through ratiometric photoacoustic (PA) imaging. The NP further guide vivo therapeutic effect...
Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT-induced providing singlet oxygen from stored chemical energy may enhance cell-killing effect and boost therapeutic Herein, we present a phototheranostic (DPPTPE@PEG-Py NPs) prepared by using 2-pyridone-based diblock polymer (PEG-Py) to encapsulate semiconducting, heavy-atom-free pyrrolopyrrolidone-tetraphenylethylene (DPPTPE) with high singlet-oxygen-generation...
Semiconducting molecules of perylene diimide (PDI) with strong light absorption properties in the near-infrared region and good biocompatibility have received increasing attention field theranostics, especially as photoacoustic (PA) imaging agents. Herein, we report a series [64Cu]-labeled PDI nanoparticles (NPs) different sizes (30, 60, 100, 200 nm) dual positron emission tomography (PET) PA probes photothermal therapy The precise size control NPs can be achieved by adjusting initial...
2D nanomaterials have attracted broad interest in the field of biomedicine owing to their large surface area, high drug-loading capacity, and excellent photothermal conversion. However, few studies report "enzyme-like" catalytic performance because it is difficult prepare enzymatic nanosheets with small size ultrathin thickness by current synthetic protocols. Herein, a novel one-step wet-chemical method first proposed for protein-directed synthesis MnO
ConspectusPrecision medicine requires noninvasive and accurate early diagnosis individually appropriate treatments. Phototheranostics has been considered a frontier precision medical technology to provide rapid safe disease localization efficient cure. Harnessing the power of advanced nanomedicine with photonics, phototheranostics is rapidly developing progressively becoming irreplaceable in modern medicine.Nanoscale semiconducting materials, such as inorganic semiconductors, organic...
In the present study, we report development of magnetic–plasmonic bilayer vesicles assembled from iron oxide–gold Janus nanoparticles (Fe3O4–Au JNPs) for reactive oxygen species (ROS) enhanced chemotherapy. The amphiphilic Fe3O4–Au JNPs were grafted with poly(ethylene glycol) (PEG) on Au surface and ROS-generating poly(lipid hydroperoxide) (PLHP) Fe3O4 surface, respectively, which then into containing two closely attached NPs layers in opposite directions. self-assembly mechanism bilayered...
Abstract Improving singlet oxygen ( 1 O 2 ) lifespan by fractionated delivery in dark and hypoxic conditions is a better way to achieve enhanced phototherapeutic efficacy. Herein, three boron dipyrromethene (BODIPY) dyes are synthesized demonstrate that anthracence‐functionalized BODIPY, namely ABDPTPA an efficient heavy‐atom‐free photosensitizer for the reversible capture release of . The spin–orbit charge‐transfer intersystem crossing promises high quantum yield 60% dichloromethane. Under...
Abstract The outcome of radiotherapy is significantly restricted by tumor hypoxia. To overcome this obstacle, one prevalent solution to increase intratumoral oxygen supply. However, its effectiveness often limited the high metabolic demand for O 2 cancer cells. Herein, we develop a hybrid semiconducting organosilica-based nanoeconomizer pHPFON-NO/O combat Our twofold: first, interacts with acidic microenvironment release NO endogenous conservation; second, it releases in response mild...