A5101770614- Inflammatory Bowel Disease
- Nutrition and Health in Aging
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Eosinophilic Esophagitis
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Diet and metabolism studies
- Hepatitis B Virus Studies
- Clinical Nutrition and Gastroenterology
- Gout, Hyperuricemia, Uric Acid
- MicroRNA in disease regulation
- Agriculture, Soil, Plant Science
- Cancer-related molecular mechanisms research
- Esophageal and GI Pathology
Qingdao University
2014-2024
Affiliated Hospital of Qingdao University
2013-2024
Nanjing Normal University
2010
Medizinische Hochschule Hannover
2008
Abstract Background Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked CRC recently. this study, we explored mechanisms underlying the role of in progression a mouse model. Methods C57BL/6 J-Adenomatous polyposis coli (APC) Min/J mice [APC (Min/+)] were treated with (10 9 cfu/mL, 0.2 mL/time/day, i.g., 12 weeks), saline, or FadA knockout (FadA−/−)...
Abstract Purpose Inulin is a type of fermentable dietary fiber, which non-digestible, and can improve metabolic function by modulating intestinal microbiota. This study aimed to evaluate the role inulin in hyperuricemia microbial composition gut microbiota mouse model established through knockout Uox (urate oxidase) gene. Methods KO ( -knockout) WT (wild-type) mice were given or saline gavage for 7 weeks. The effect combat was determined assessing changes serum UA (uric acid) levels,...
Patients with inflammatory bowel disease (IBD) often have low weight, malnutrition and sarcopenia. The criteria of sarcopenia used were European American standards previously. aim the study was to evaluate impact on clinical outcomes in patients IBD using Asian Working Group for Sarcopenia 2019 (AWGS2019) criteria.The inclusion subjects between 18 60 years. Sarcopenia, pre-sarcopenia sarcopenic obesity defined. Participants followed up 90 days. Information as whether symptoms improved,...
Fucoidan is a natural bioactive product with broad therapeutic applications. Hepatocellular carcinoma (HCC) common malignancy of the liver associated relatively high mortality rate; thus, effective treatments are urgently needed. Here, effects fucoidan on HCC and underlying mechanism were explored.The proliferation apoptosis two cell lines (BEL-7402 LM3) treated different concentrations or saline assessed. The levels proliferating nuclear antigen (PCNA) CCK8 assay used to determine...
Abstract This article documents the addition of 411 microsatellite marker loci and 15 pairs Single Nucleotide Polymorphism (SNP) sequencing primers to Molecular Ecology Resources Database. Loci were developed for following species: Acanthopagrus schlegeli, Anopheles lesteri, Aspergillus clavatus, flavus, fumigatus, oryzae, terreus, Branchiostoma japonicum, belcheri, Colias behrii, Coryphopterus personatus, Cynogolssus semilaevis, Cynoglossus Dendrobium officinale, Dysoxylum malabaricum,...
Inflammatory bowel disease (IBD) is believed to be caused by various factors, including abnormalities in susceptibility genes, environmental immune and intestinal bacteria. Proton pump inhibitors (PPIs) are the primary drugs used treat acid-related diseases. They also commonly prescribed patients with IBD. Recent studies have suggested a potential association between use of certain medications, such as PPIs, occurrence progression In this review, we summarize impact PPIs on IBD analyze...
The aim of this study is to identify and consolidate reliable endoscopic features associated with H. pylori infection in gastric mucosa, which one the major causes cancer. A total 256 Chinese patients symptomatic stomach disturbances were enrolled. Pathological examination was conducted using a light microscope biopsy specimens stained hematoxylin-eosin. Endoscopic performed high resolution video endoscope. association between pathological diagnosis compared, significantly identified. 14...
Hepatocellular carcinoma (HCC) is a common malignant tumor with high fatality rate. Recent studies reported that up-regulation of long non-coding RNA antisense in the INK4 locus (lncRNA ANRIL) was found HCC tissues, and which could affect cells biological processes. However, potential molecular mechanism ANRIL still unclear. The study aimed to uncover effect on HepG2 growth, migration invasion.
Ulcerative colitis (UC) is considered an immune-mediated disease. The disorder of T-lymphocyte subsets plays important role in the pathogenesis UC. aim this study was to evaluate significance peripheral blood assessing disease severity and predicting clinical outcomes UC patients.The retrospective case-control performed 116 patients with active 90 healthy controls (HC). included were followed up for 180 days. Analyses t-test, Spearman's correlation coefficient, multivariable Cox regression...
Objective To investigate the association between dietary and some other environmental factors risk of inflammatory bowel diseases (IBD) in Chinese population. Materials methods A multicenter case-control study was conducted involving 11 hospitals across China. total 1,230 subjects were enrolled consecutively, diet factor questionnaires collected. IBD patients matched with healthy controls (HC) using propensity-score matching (PSM) at a 1:1 ratio caliper value 0.02. Multivariate conditional...
Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue lymphoma compared with other species in humans and animals. Saccharomyces boulardii been established as an adjunct H. pylori eradication treatment, but the effect of S. administration alone on infection remains unclear. Here, we found that effectively decreased bacterial load inhibited formation follicles stomach post-infection. The levels suis-specific immunoglobulin A (IgA) secretory IgA juice...
Endoscopic removal of GISTs (gastrointestinal stromal tumors) is recently recognized, but less known about its efficacy and safety. This study aimed at assessing the feasibility, clinical efficacy, safety endoscopic gastric GISTs. (ER) was performed in 134 patients our hospital between January 2015 2019. The features, surgical outcomes, complications, pathological diagnosis, risk classification were evaluated retrospectively. ER successful 131 cases (98%), including 58 by ESD (endoscopic...
Abstract Background The significance of endoscopic evaluation in the diagnosis and management ulcerative colitis (UC) has been widely recognized. Over years, scholars have established several scores. Herein, we assessed clinical application value Mayo Endoscopic Subscore (Mayo ES), Degree Ulcerative Colitis Burden Luminal Inflammation (DUBLIN) score, Index Severity (UCEIS) score UC patients, by comparing their correlation with disease activity predictive potential for treatment response...
Sarcopenia leads to complications (infections, hepatic encephalopathy and ascites) poor overall survival in patients with cirrhosis, which the phenotypic presentation is loss of muscle mass. This study aimed reveal metabolic profile identify potential biomarkers cirrhotic hepatitis B virus mass loss.Twenty decompensated HBV were designated Group S; 20 normal NS; healthy people H. Muscle was defined as skeletal index less than 46.96 cm2/m2 for males 32.46 females. Gas chromatography-mass...
Endoscopic evaluation in diagnosing and managing ulcerative colitis (UC) is becoming increasingly important. Several endoscopic scoring systems have been established, including the Ulcerative Colitis Index of Severity (UCEIS) score Mayo Subscore (MES). Furthermore, Toronto Inflammatory Bowel Disease Global Reporting (TIGER) for UC has recently proposed; however, its clinical value remains unclear.
Background Ulcerative colitis (UC) is a disease characterized by chronic relapsing-remitting inflammatory disorders and associated with environmental changes.
Vedolizumab (VDZ), a monoclonal antibody to α4β7 integrin, is available for patients with moderate-to-severe ulcerative colitis (UC). This study planned assess the real-world effectiveness and safety of VDZ UC in Northern China. We enrolled who underwent induction therapy from March 2021 November 2022 at Affiliated Hospital Qingdao University. The primary outcome was clinical remission weeks 14 52 after initial therapy. Overall adverse events risk factors associated loss response (LOR) were...