A5100437840- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA regulation and disease
- Cancer, Lipids, and Metabolism
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
Nanjing Medical University
2020-2024
Jiangsu Province Hospital
2020-2024
Chongqing Public Health Medical Center
2023
Chongqing Medical University
2023
Huazhong University of Science and Technology
2021-2022
Union Hospital
2021
Henan Cancer Hospital
2020
Zhengzhou University
2020
Zhongda Hospital Southeast University
2020
Long noncoding RNAs (lncRNAs) play critical roles in the pathogenesis of various diseases, including a variety tumors. Nevertheless, its functional and underlying molecular basis for their dysregulation lung adenocarcinoma (LUAD) are largely unknown. Herein, our study, we identified that lncRNA TMPO-AS1 is significantly upregulated LUAD tissues cell lines. Knockdown remarkably suppressed growth, induced apoptosis as well G1/S arrest, inhibited invasion, whereas overexpression exerts opposite...
Abstract Long noncoding RNAs (lncRNAs) are known to play a key role in chronic myelocytic leukemia (CML) development, and we aimed identify the involvement of lncRNA HOX antisense intergenic RNA (HOTAIR) CML via binding DNA methyltransferase 1 (DNMT1) accelerate methylation phosphatase tensin homolog (PTEN) gene promoter. Bone marrow samples from patients normal bone healthy controls were collected. HOTAIR, DNMT1, DNMT3A, DNMT3B, PTEN expression was detected. The biological characteristics...
Methylation is a fundamental regulator of gene transcription. Long non-coding RNA maternally expressed 3 (MEG3) inhibits cell proliferation in various types cancer. However, the molecular mechanisms MEG3 methylation regulation multiple myeloma (MM) are unknown. In present study, upregulation was negatively associated with International Staging System (ISS) status bone marrow samples 39 patients MM. overexpression an MM line resulted elevated p53 expression. Furthermore, results...
The oncogenic role of lncRNA ELFN1-AS1 has been described in different cancers, including colon cancer (CC). However, how regulates CC malignancy remains unclear. In this study, ELFN1-AS1, AURKB, and miR-4270 expression levels cells tissues were determined using RT-qPCR western blotting. CCK-8 wound healing assays also performed to analyze alterations cell proliferation migration. apoptosis-related proteins (Bax Bcl-2) was via blot analysis. RNA immunoprecipitation (RIP) coupled with...
Long noncoding RNAs (lncRNAs) have been implicated in coronary artery disease (CAD) processes. However, the relationship between gene polymorphisms of lncRNA RP1-276N6.2 as a novel molecule and susceptibility to CAD remains unclear. In our case-control study, 949 patients 892 healthy controls were genotyped using TaqMan genotyping assay. The quantitative real-time polymerase chain reaction enzyme-linked immunosorbent assay performed examine expression levels SLC22A3(OCT3). We observed that...