A5103016253- Cancer-related molecular mechanisms research
- Cellular transport and secretion
- MicroRNA in disease regulation
- Biochemical and Structural Characterization
- RNA modifications and cancer
- Antimicrobial Peptides and Activities
- Carbon and Quantum Dots Applications
- Drug Solubulity and Delivery Systems
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Echinoderm biology and ecology
- Circular RNAs in diseases
- Advanced Drug Delivery Systems
- Protein Hydrolysis and Bioactive Peptides
- Aquatic life and conservation
- Cell Adhesion Molecules Research
- Polysaccharides and Plant Cell Walls
- Hedgehog Signaling Pathway Studies
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Antimicrobial agents and applications
- Cellular Mechanics and Interactions
- Extracellular vesicles in disease
Zhengzhou University
2014-2025
Henan Cancer Hospital
2020-2025
Wuhan Polytechnic University
2023-2024
Shandong Academy of Sciences
2023-2024
Qilu University of Technology
2023-2024
Dalian University of Technology
2020
Dalian University
2020
Thomas Jefferson University
2005-2010
Shenyang Pharmaceutical University
2010
Sidney Kimmel Cancer Center
2005-2008
Antimicrobial peptides (AMPs) offer an opportunity to overcome multidrug resistance. Here, novel were designed based on AMP fragments derived from sea cucumber hemolytic lectin enhance anti-methicillin-resistant Staphylococcus aureus (MRSA) activity with less side effects. Two peptides, CGS19 (LARVARRVIRFIRRAW-NH2) and CGS20 (RRRLARRLIFFIRRAW-NH2), exhibited strong antibacterial activities against clinically isolated MRSA MICs of 3–6 μM, but no obvious cytotoxicity was observed....
Differences between CDs prepared by microwave reaction and conventional hydrothermal methods were systematically compared to guide the optimization of parameters biomass-derived CDs.
Long noncoding RNAs (lncRNAs) play critical roles in the pathogenesis of various diseases, including a variety tumors. Nevertheless, its functional and underlying molecular basis for their dysregulation lung adenocarcinoma (LUAD) are largely unknown. Herein, our study, we identified that lncRNA TMPO-AS1 is significantly upregulated LUAD tissues cell lines. Knockdown remarkably suppressed growth, induced apoptosis as well G1/S arrest, inhibited invasion, whereas overexpression exerts opposite...
We report here detection of novel intracellular clathrin‐coated structures revealed by continuous high‐speed imaging cells expressing green fluorescent protein fusion proteins. These structures, which we operationally term ‘gyrating clathrin’ (G‐clathrin), are characterized localized but extremely rapid movement, leading to the hypothesis that they coated buds on waving membrane tubules. G‐clathrin have structurally and functionally distinct features. They lack detectable adaptor proteins...
We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms risk hepatocellular carcinoma (HCC). A matched case-control study 152 cases 304 controls were conducted. The genotypes analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients more likely to be smokers drinkers, have hepatitis B C virus infections, a family history cancer. miR-149 CC genotype was associated reduced HCC, while miR-499 GG an increased HCC....
Long noncoding RNAs (lncRNAs) are dysregulated in various malignancies and involved the growth aggressive phenotypes of cancer cells. Previous studies indicate that lncRNA testis development related 1 (TDRG1) plays critical roles several malignancies. Nevertheless, molecular mechanism underlying TDRG1 contributes to non-small cell lung (NSCLC) remains elusive. Here, we demonstrate is significantly overregulated NSCLC tissues lines. Knockdown inhibits proliferation metastatic-related traits...
Hypoxia is a common characteristic of solid tumors and associated with cancer progression poor outcomes.However, the roles specific mechanisms exosomes hypoxia during still remain unclear.Herein, we found that secreted from hypoxic colorectal (CRC) cells promoted proliferation, migration, invasion, metastasis normoxic CRC cells, these exerted their biological effects depending on miR-410-3p.We discovered miR-410-3p was highly enriched in CRC-derived HIF1α or HIF2α-dependent manner, levels...
2595 Background: Tumor mutational burden (TMB) has emerged as a predictive biomarker of immune checkpoint blockade response in cancers. Envafolimab, humanized single-domain anti-PD-L1 antibody subcutaneous administration (s.c.), been approved China for the treatment advanced solid tumors with MSI-H. The study is to explore potential anti-tumor activity patients TMB-high (TMB-H) China. Methods: consists two parts. Part 1 association single agent envafolimab tissue TMB (tTMB) measured by...
Arsenic was recently identified as a pollutant that is major cause of lung cancer. Since heparin-binding EGF-like growth factor (HB-EGF) reported to be promising therapeutic target for cancer, we investigated the role and mechanism HB-EGF during arsenic-induced carcinogenesis development expression were upregulated in As-T cells, cancer cell lines, most tissue samples; activated EGFR/p-ERK/HIF-1α pathway induced VEGF by regulating HIF-1α transcription. transcriptional stimulation facilitated...
The ability to rapidly and specifically regulate protein activity combined with in vivo functional assays and/or imaging can provide unique insight into underlying molecular processes. Here we describe the application of chemically induced dimerization FKBP create nearly instantaneous high-affinity bivalent ligands capable sequestering cellular targets from their endogenous partners. We demonstrate specificity efficacy these inducible, dimeric "traps" for dynein light chains LC8 (Dynll1)...
A case-control study of the association miR-499A>G rs3746444 with risk hepatocellular carcinoma (HCC)was conducted. Patients HCC and healthy control subjects were recruited for genotyping miR- 499A>G using duplex polymerase-chain-reaction confronting-two-pair primer(PCR-RFLP) analysis. The MiR-499 GG genotype was associated a decreased as compared miR-499 AA (adjusted OR=0.74, 95%CI=0.24-0.96). Similarly, showed 0.45-fold in recessive model. G allele significantly among patients infected HBV...
With the abuse of antibiotics, more and drug-resistant strains have emerged clinically Antimicrobial peptides kill bacteria by inhibiting synthesis nucleic acid protein in cell membrane regulating cellular immune response. Because its bactericidal mechanism, antimicrobial can many gram-negative gram-positive are not easy to develop drug resistance, they good candidates for a new generation antibiotics treat multidrug-resistant Sea cucumber is one excellent sources peptides, but there few...
Through modification, this work significantly enhances the quantum yield of carbon dots derived from fish scales and applies them for trace detection quercetin.
<p>PDF file - 2605K, Fig. S1. X-gal staining of SMG sections from Ptch1-lacZ mice non-treated (NT), 7 days after ligation main excretory ducts or IR. S2. Dox treatment did not rescue IR-induced hyposalivation in female KrtrtTA/ tetO-Shh and male wild type mice. (A) Relative saliva flow rate. (B) expression acinar markers Aqp5 Chrm3 determined by qRT-PCR. S3. Transient Hh activation has no long-term effect on percentage putative salivary stem/progenitor cells. S4. Effects transient...