Yaokun Li

ORCID: 0000-0002-9211-0244
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Cancer-related molecular mechanisms research
  • Genetic and phenotypic traits in livestock
  • Ruminant Nutrition and Digestive Physiology
  • Reproductive Physiology in Livestock
  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • Genetic Mapping and Diversity in Plants and Animals
  • RNA modifications and cancer
  • Reproductive System and Pregnancy
  • Reproductive Biology and Fertility
  • Effects of Environmental Stressors on Livestock
  • Epigenetics and DNA Methylation
  • Moringa oleifera research and applications
  • RNA Research and Splicing
  • Molecular Biology Techniques and Applications
  • Animal health and immunology
  • Meat and Animal Product Quality
  • Phytase and its Applications
  • Adipose Tissue and Metabolism
  • Geotechnical Engineering and Underground Structures
  • Animal Genetics and Reproduction
  • Pancreatitis Pathology and Treatment
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Livestock Farming and Management
  • Civil and Geotechnical Engineering Research

South China Agricultural University
2018-2025

Key Laboratory of Guangdong Province
2020-2021

Northwest A&F University
2012-2020

University of Maryland, College Park
2017-2020

South China University of Technology
2016-2018

Huazhong Agricultural University
2018

Wuhan University of Technology
2015

Abstract Beef represents a major dietary component and source of protein in many countries. With an increasing demand for beef, the industry is currently undergoing changes towards naturally produced beef. However, true differences between feeding systems, especially biochemical nutritional aspects, are still unclear. Using transcriptome metabolome profiles, we identified biological pathways related to grass- grain-fed Angus steers. In latissimus dorsi muscle, have recognized 241...

10.1038/srep25948 article EN cc-by Scientific Reports 2016-05-17

Heat stress has a severe effect on animal health and can reduce the productivity reproductive efficiency; it is therefore necessary to explore molecular mechanism involved in heat response, which helpful for cultivation of an breed with resistance stress. However, little research about stress-responsive analysis been reported sheep. Therefore, this study, RNA sequencing (RNA-Seq) was used investigate transcriptome profiling liver Hu sheep without In total, we detected 520 22 differentially...

10.3390/genes10050395 article EN Genes 2019-05-22

Abstract Background Fertility is an important economic trait in the production of meat goat, and follicular development plays role fertility. Although many mRNAs microRNAs (miRNAs) have been found to play critical roles ovarian biological processes, interaction between miRNAs not yet completely understood. In addition, less attention has given study single follicle (dominant or atretic follicle) goats. This aimed identify mRNAs, miRNAs, signaling pathways as well their networks follicles...

10.1186/s12864-020-6671-4 article EN cc-by BMC Genomics 2020-03-30

Capsaicin is the active ingredient of red pepper plant genus Capsicum. The aim this study was to investigate effects different doses capsaicin on growth performance, antioxidant capacity, immunity, fecal fermentation parameters and gut microbial composition in nursing calves. Twenty-four newborn Holstein calves were randomly assigned three treatment groups, which each consisted eight milk replacer supplemented with 0, 0.15 or 0.3 mL/d groups. During 4-week experiment, intake recorded daily,...

10.3390/ani13142309 article EN cc-by Animals 2023-07-14

This study investigates the effects of varying energy levels in diets on Black Angus steers, focusing growth performance, muscle composition, rumen microbial community, and their interrelationships. Twenty-seven aged approximately 22 months weighing 520 ± 40 kilograms, were randomly divided into three groups: low-energy (LE), medium-energy (ME), high-energy (HE). Each group consisted nine individuals. The steers fed with 6.657 MJ/kg 7.323 7.990 (HE) following a 14-day pre-feeding period,...

10.3389/fmicb.2024.1378073 article EN cc-by Frontiers in Microbiology 2024-05-06

Striped bass (Morone saxatilis) spermatozoa are used to fertilize in vitro the eggs of white (M. chrysops) produce preferred hybrid for striped aquaculture industry. Currently, only one source domestic juveniles is available growers that not obtained from wild-caught parents and thus devoid any genetic improvement phenotypic traits importance aquaculture. Sperm epigenetic modification has been predicted be associated with fertility, which could switch genes on off without changing DNA...

10.1186/s12864-018-4548-6 article EN cc-by BMC Genomics 2018-04-10

This study aimed to investigate the effects of oat hay feeding method and compound probiotics (CMP) on growth, health, serum antioxidant immune indicators, rumen fermentation, bacteria community dairy calves from 3 5 months age. Forty-eight female Holstein (80 ± 7 days age, 93.71 5.33 kg BW) were selected randomly divided into four groups. A 2 × factorial design was adopted for experiment, with factors (fed as free-choice or 16.7% in diet) inclusion (0.15% 0%) pelleted starter. The results...

10.3390/antiox12101851 article EN cc-by Antioxidants 2023-10-12

The proliferation and apoptosis of granulosa cells (GCs) affect follicle development reproductive disorders, with microRNAs playing a crucial regulatory role. Previous studies have shown the differential expression miR-128-3p at different stages goat development, which suggests its potential role in development. In this study, through Cell Counting Kit-8 assay, EDU flow cytometry, quantitative real-time polymerase chain reaction, Western blot, dual-luciferase reporter we used immortal human...

10.3390/ijms25052720 article EN International Journal of Molecular Sciences 2024-02-27

Many studies have shown that only a few breeds of goat the trait high fertility, and genes play an important role in regulating litter size. This study investigated effects GnRHR, BMP6, FSHR gene polymorphisms on traits four (Chongqing black, Chuanzhong Leizhou, Nubian). Single nucleotide (SNPs) (g.75G > A g.951T C g.-112C T/g.3236C FSHR) were genotyped using PCR-RFLP/HRM 959 goats. Association analysis revealed significant correlations between these SNPs size Chongqing, Chuanzhong,...

10.3390/ani15101358 article EN cc-by Animals 2025-05-08

The present study aimed to investigate the colonization process of epithelial bacteria attached rumen and intestinal tract tissue during development goats after birth. However, this from fetus adulthood was very limited. In goats, cecum are two important fermentation organs, it is acquisition neonatal microbiome, as well difference between these organs. To characterize microbial establishment dynamic changes in adulthood, we performed 16S rRNA gene sequencing for 106 samples 47 individuals...

10.3390/ani10091639 article EN cc-by Animals 2020-09-11

This study investigated the effects of substitution whole corn silage (WCS) with Broussonetia papyrifera (BPS) in different ratios on serum indicators, hindgut fermentation parameters (pH, ammoniacal nitrogen, and volatile fatty acids), fecal bacterial community Holstein heifers. Sixteen heifers (8-month-old, 220 ± 30 kg) were randomly divided into four treatments according to BPS feed basis (0%, 25%, 50%, 75%). The experiment consisted a 7-day preliminary feeding period 30-day experimental...

10.1186/s13568-020-01135-y article EN cc-by AMB Express 2020-10-31

Chinese local cattle with a high level of genetic diversity mainly originate from two subspecies; the in northern China are primarily Bos Taurus , and southern indicus . Cattle characterized by specific phenotype adapted to environment. This study explored diversity, degree admixture, selection signature eight breeds China. The lowest heterozygosity was found Hainan Nandan Guangxi province, respectively, whereas highest detected Zhaotong Yunnan province. A neighbor-joining phylogenetic tree...

10.3389/fgene.2020.533052 article EN cc-by Frontiers in Genetics 2020-12-18

Runs of homozygosity (ROH) are continuous homozygous segments from the common ancestor parents. Evaluating ROH pattern can help to understand inbreeding level and genetic basis important traits. In this study, three representative cattle populations including Leiqiong (LQC), Lufeng (LFC) Hainan (HNC) were genotyped using Illumina BovineHD SNPs array (770K) assess at genome wide level. Totally, we identified 26,537 with an average 153 per individual. The sizes ranged 0.5 53.26Mb, length was...

10.1371/journal.pone.0271718 article EN cc-by PLoS ONE 2022-08-25

Litter size is an important indicator to measure the reproductive performance of goats, which affected by function animals. The hypothalamus, as regulatory center endocrine system, plays role in reproduction female Here, we performed high-throughput RNA sequencing using hypothalamic tissue from high-fecundity and low-fecundity Leizhou goats explore critical functional genes associated with litter size. Differentially expressed mRNA, lncRNA, circRNAs were screened DESeq enriched, then...

10.3390/genes14020444 article EN Genes 2023-02-09

In this study, changes in milk performance, nutrient digestibility, hindgut fermentation parameters and microflora were observed by inducing fat depression (MFD) dairy cows fed with a high-starch or high-fat diet. Eight Holstein paired completely randomized cross-over design within two 35 d periods (18 control period 17d induction period). During the period, all low-starch low-fat diet (CON), at four of crushed wheat (IS), other sunflower (IO). The results showed that, compared to when CON...

10.3390/ani13152508 article EN cc-by Animals 2023-08-03

Beef represents a major diet component and one of the sources protein in human. The beef industry United States is currently undergoing changes facing increased demands especially for natural grass-fed beef. obtained their nutrients directly from pastures, which contained limited assimilable energy but abundant amount fiber. On contrary, grain-fed steers received grain-based regime that served as an efficient source high-digestible energy. Lately, ruminant animals have been accused to be...

10.1371/journal.pone.0116437 article EN cc-by PLoS ONE 2015-06-19

Beef is an essential food source in the world. quality, especially tenderness, has a significant impact on consumer satisfaction and industry profit. Many types of research to date have focused exploration physiological developmental mechanisms beef tenderness. Still, role DNA methylation status tenderness yet be elucidated. In this study, we exhaustively analyzed divergent observed Angus beef. We characterized profiles related explored distributions whole genome. As result, differentially...

10.3389/fgene.2020.00939 article EN cc-by Frontiers in Genetics 2020-08-26
Coming Soon ...