A5101635592- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- High Altitude and Hypoxia
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Orthopedic Infections and Treatments
- Mycobacterium research and diagnosis
- Pleural and Pulmonary Diseases
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
Shanghai Public Health Clinical Center
2025
Shandong Chest Hospital
2015-2021
Shandong Agricultural University
2021
Shandong First Medical University
2021
Fourth People’s Hospital of Jinan
2021
Shandong University
2020
To measure the expression levels of sputum and serum microRNA-144 (miR-144) before after treatment patients with tuberculosis (TB).Details cases a total 124 TB were collected at Qilu Hospital Shandong University between April 2014 2015. Fifty-three these had positive for bacteria cavity on imaging (group A), 20 negative B), 51 no C). One hundred seventeen healthy people who attended hospital physical examination recruited as controls. Quantitative real-time PCR (qRT-PCR) was used to miR-144...
MicroRNAs (miRNAs) regulate multiple cellular behaviors, and their aberrant expression is frequently associated with disease progression. This research focused on the effects of miR-520a development non-small-cell lung cancer (NSCLC) molecules involved. Tumor normal tissues from 24 patients NSCLC were collected. Differentially expressed miRNAs between tumor screened using microarrays, was to be significantly poorly in samples. Artificial upregulation reduced proliferation, migration...
8573 Background: Immunotherapy combined with chemotherapy has been established as the standard first-line treatment for patients advanced squamous NSCLC (sq-NSCLC) without oncogenic driver mutations. Antiangiogenic drugs enhance immunotherapy efficacy by normalizing blood vessels and remodeling tumor microenvironment. However, they pose a high bleeding risk in sq-NSCLC treatment. Recombinant human endostatin (Rh-endostatin), only approved agent sq-NSCLC, can prolong survival increasing risk....
Effect of targeted regulation mothers against decapentaplegic homolog 3 (Smad3) by microRNA-15a (miR-15a) on the proliferation, invasion and metastasis non-small cell lung cancer (NSCLC) cells its related mechanisms were investigated. Fifty pairs NSCLC para-cancerous tissues collected to identify expression level miR-15a in NSCLC, tissue, lines A549, H1299, H1975 BEAS-2B real-time fluorescence quantitative PCR (RT-PCR); A549 transfected with mimic; MTT assay was performed detect role...
Hypoxia is a prominent feature of solid cancer. This research aims to expose the role mitochondrial creatine kinase 1 (CKMT1) in non-small cell lung cancer (NSCLC) progression and hypoxia adaptation.The mRNA protein expression CKMT1 NSCLC tissues were detected by using GEPIA web, immunohistochemistry qRT-PCR. For hypoxia, cells exposed 1% O2 atmosphere. The levels HIF-1α H1650 H1299 determined western blot. roles on proliferation, invasion adaptation measured CCK8, colony formation transwell...
Background Pleural effusion (PE) Xpert has limited use in the diagnosis of pleural tuberculosis (TB). However, diagnostic incremental value sputum for TB remains unclear.Materials and methods Between March 2018 October 2019, patients with certain causes (such as TB, malignancy, pneumonia) PE were enrolled our study. Sputum collected from all sent acid-fast bacilli smear (Auramine O staining), mycobacterial culture (Lowenstein-Jensen media), Xpert. The differences sensitivities these assays...
Abstract The authors have withdrawn this preprint due to erroneous posting.
Abstract Background Increasingly evidence has noted the critical functions of microRNAs (miRNAs) in disease control including cancer progression. This paper aimed to explore miR-520a lung (LC) and downstream molecules implicated. Methods Aberrantly expressed miRNAs LC tissues were screened out by miRNA microarrays. expression cell lines was determined, correlation between level survival rate patients analyzed. Altered introduced evaluate its function malignant behaviors. The target mRNA...
Abstract Background Hypoxia is a prominent feature of solid cancer. This research aims to expose the role mitochondrial creatine kinase 1 (CKMT1) in non-small cell lung cancer (NSCLC) progression and hypoxia adaptation. Methods The mRNA protein expression CKMT1 NSCLC tissues cells were detected using GEPIA web, immunohistochemistry, qRT-PCR western blot. Cells exposed hypoxic chamber with atmosphere containing 5% CO 2 , 1% O residual N . levels HIF-1α H1650 H1299 determined by Luciferase...