A5101877589- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Mangiferin and Mango Extracts
- Cancer therapeutics and mechanisms
- Plant-based Medicinal Research
- Plant biochemistry and biosynthesis
- Peptidase Inhibition and Analysis
- Phytochemistry and Biological Activities
- Ferroptosis and cancer prognosis
- Graphene and Nanomaterials Applications
- Plant Gene Expression Analysis
- DNA Repair Mechanisms
- Supramolecular Self-Assembly in Materials
- Traditional Chinese Medicine Analysis
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Fungal Biology and Applications
- Metabolomics and Mass Spectrometry Studies
- Biochemical and biochemical processes
- Cancer, Hypoxia, and Metabolism
Guangzhou University of Chinese Medicine
2024
Peking University First Hospital
2023
Peking University
2023
Xiamen University
2022
Shandong Chest Hospital
2018-2021
Harbin Institute of Technology
2020-2021
Mitochondria are highly dynamic organelles and undergo constant fission fusion, which both essential for the maintenance of cell physiological functions. Dysregulation dynamin-related protein 1 (Drp1)-dependent mitochondrial dynamics is associated with tumorigenesis chemotherapeutic response in hepatocellular carcinoma (HCC). The enzyme cyclooxygenase-2 (COX-2) overexpressed most cancer types correlates a poor prognosis. However, roles played by translocation COX-2 (mito-COX-2) interaction...
MicroRNAs (miRNAs) regulate multiple cellular behaviors, and their aberrant expression is frequently associated with disease progression. This research focused on the effects of miR-520a development non-small-cell lung cancer (NSCLC) molecules involved. Tumor normal tissues from 24 patients NSCLC were collected. Differentially expressed miRNAs between tumor screened using microarrays, was to be significantly poorly in samples. Artificial upregulation reduced proliferation, migration...
To study the effect and potential mechanism of LKB1 on non-small cell lung cancer (NSCLC) A549 cells.A549 cells were divided into control group, negative (NC) ERK inhibitor group + activator group. Cell proliferation apoptosis detected by counting kit (CCK-8) assay flow cytometry, respectively. Transwell was used to analyze invasion ability cells. The expression signaling pathway-related proteins studied Western blot. Furthermore, a nude mouse xenograft model constructed treated with LKB1,...
A novel gallotannin, crenulatin ( 7), has been isolated from RHODIOLA CRENULATA. The structure was elucidated by spectral analyses (including 2D-NMR measurements) and chemical methods. Also six known polyphenols have identified.
Ophiocordyceps sinensis ( O. ) seems to be able alleviate airway epithelial cell senescence in chronic obstructive pulmonary disease (COPD). The objective of the study is evaluate effect on COPD model both vitro and vivo. We observed expression P16 P21 epithelia 30 patients with COPD. optimal concentration exposure time cigarette smoke extract (CSE) were determined vitro, senescence-associated β -galactosidase (SA- -gal) 5-bromodeoxyuridine (BrdU) used proliferation human bronchial (16HBE)...
Abstract BackgroundTumor easily develops resistance to anti-cancer drugs leading decreased therapy efficiency of chemotherapies. Targeting signaling molecules related with chemoresistance through strategy co-delivery siRNA and chemotherapeutics may overcome the multidrug chemotherapy. A nanosystem that could carry DOX simultaneously has been studied in this work. ResultsThe is based on carbon dots was surface-modified poly-ethylenimine (PEI), loaded siMRP1 surface pH-triggered drug release....
Abstract The authors have withdrawn this preprint due to erroneous posting.
Abstract BackgroundThe resistance to the anti-cancer agent limits chemotherapy effect in cancer therapy. Tumor easily develops drugs leading decreased therapy efficiency of chemotherapies. Targeting signaling molecules related with chemoresistance through strategy co-delivery siRNA and chemotherapeutics may overcome multidrug chemotherapy. A nanosystem that could carry DOX simultaneously has been studied this work. ResultsThe is based on carbon dots was surface-modified poly-ethylenimine...