A5019472642- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- RNA Research and Splicing
- Blood Pressure and Hypertension Studies
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Cardiac Arrhythmias and Treatments
- Epigenetics and DNA Methylation
- Cardiac pacing and defibrillation studies
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Peptidase Inhibition and Analysis
- Cardiovascular Function and Risk Factors
- Genomics and Chromatin Dynamics
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Supramolecular Self-Assembly in Materials
- Acute Myocardial Infarction Research
- Gout, Hyperuricemia, Uric Acid
- Case Reports on Hematomas
- Cardiovascular Syncope and Autonomic Disorders
- Toxin Mechanisms and Immunotoxins
- DNA Repair Mechanisms
- Moyamoya disease diagnosis and treatment
Songjiang District Central Hospital
2023-2025
Shanghai Jiao Tong University
2024-2025
Changchun University of Chinese Medicine
2024
Shanghai Medical College of Fudan University
2023
Shanghai First People's Hospital
2023
Nanjing Medical University
2023
Weifang People's Hospital
2008-2022
Harbin Normal University
2020
Peking University
2019
Peking University People's Hospital
2019
ABSTRACT Pulse pressure (PP) is a recognized marker of cardiovascular risk in the general population. However, its role as an independent predictor recurrent events following myocardial infarction (MI) and whether there are age‐dependent differences this relationship remains uncertain. We analyzed data from 4091 participants with history MI were enrolled Kailuan Study. Univariate multivariable Cox models used to analyze associations between PP primary outcome (composite events, composite...
Previous studies have reported that inflammatory responses can promote the onset of cardiovascular diseases; however, its association with cardiac conduction disorders remains unclear. The present community-based cohort study aimed to elucidate effects on risk developing disorders.After exclusion participants failing meet inclusion criteria, 86,234 eligible (mean age: 50.57 ± 11.88 years) were included. divided into high-sensitivity C-reactive protein (hsCRP) ≤ 3 mg/L, and hsCRP > mg/L...
Aims and objectives. The aim is to determine the efficacy of internal external biliary drainage (ED) with special reference effect bile acid on intestinal epithelium during experimental obstruction. Methods. A total 59 male Sprague Dawley rats were randomly assigned four groups: (I) sham operation (SH); (II) obstructive jaundice (OJ); (III) OJ ED; (IV) (ID). animals underwent surgical ligation duct day 1. They reoperated 8 for procedure. Blood cultures obtained from portal vein inferior vena...
// Jiangtao Guo 1, 2, * , Wei Zhao Xuqing Cao Huiying Yang 1 Juan Ding Jingbin Zifang Tan 2 Xiaoli Ma Chunfang Hao Lili Wu Zhengjuan 3 Jianjun Xie 4 and Zhijun Wang Cancer Hospital of General Hospital, Affiliated Ningxia People's Key Laboratory Fertility Preservation Maintenance Ministry Education, Medical University, Yinchuan, China The Fifth Ningxia, Shizuishan, Pingluo Pingluo, These authors have contributed equally to this work Correspondence to: Wang, email: wangzhijun1978@hotmail.com...
BackgroundPrevious studies have shown that arterial stiffness (AS) was a risk factor for heart failure (HF) in nondiabetic patients. We aimed to analyze this impact community-based diabetic population.MethodsOur study excluded those who had HF before brachial-ankle pulse wave velocity (baPWV) measurement and included 9041 participants finally. Subjects were divided into the normal (<14 m/s), intermediate (14–18 elevated baPWV groups (>18 m/s) based on values. Multivariate Cox proportional...
Abstract The aim of this study was to analyze the correlation between free triiodothyronine (FT3), thyroxine (FT4), thyroid-stimulating hormone (TSH), and serum high-density lipoprotein cholesterol (HDL-C), explore significance FT3 in HDL-C metabolism people with normal thyroid function. A total 461 Chinese, aged ≥28 years, from a college community Nanning, Guangxi, were enrolled for cross-sectional epidemiological investigation metabolic syndrome October 2016 November 2016. Height, weight,...
RUNX1/AML1, which is a Runt family transcription factor critical for normal hematopoiesis, frequently mutated or translocated in broad spectrum of hematopoietic malignancies.We describe here the case 54-year-old female developed acute myeloid leukemia with t(5;21)(q21;q22). Transcriptome sequencing identified chromodomain-helicase-DNA-binding protein 1 gene, CHD1, as novel partner gene RUNX1. Furthermore, patient was found to harbor FLT3-ITD mutation, might collaborated CHD1-RUNX1...
This study aimed to explore the association between serum non-high-density lipoprotein cholesterol (non-HDL-C) and cognitive dysfunction risk in patients with acute ischemic stroke (AIS). cross-sectional enrolled 583 AIS patients. Biochemical markers lipid profile were collected after admission. classified into high group (non-HDL-C ≥3.4 mM) normal <3.4 mM). Mini-Mental State Examination scale (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living (ADL) scale,...
Inflammatory response is one of the important factors affecting formation intracranial aneurysm. miR-1246 involved in regulation several inflammatory diseases; however, its expression levels and mechanism action aneurysms remain further investigated.Bioinformatics was used to analyze micro-RNAs (miRNAs) serum aneurysm patients as well tissues downloaded from GEO RNA-seq database. Blood samples were collected pre-operatively with healthy volunteers, miRNA-1246 detected using quantitative...
Although bundle branch block and atrioventricular are recognized to be association with cardiovascular disease (CVD) mortality, the relationship between cardiac conduction (CCB) both CVD all-cause mortality has yet explored.
The present study was designed to investigate the prevalence and clinical significance of SIL-TAL1 rearrangements in T-cell acute lymphoblastic leukemia (T-ALL). incidence analyzed by nest real-time quantitative polymerase chain reaction (RT-PCR) 68 patients with T-ALL. Karyotypic analysis performed conventional R-banding assay array-based comparative genomic hybridization (array-CGH). results showed that were identified 10/26 (38.5%) pediatric 2/42 (4.8%) adult T-ALL cases, which indicate a...
Intracerebral hemorrhage is one of the most common types cerebrovascular disease in humans and often causes paralysis, a vegetative state even death. Patients with acute intracerebral are frequently monitored intensive care units (ICUs). Spontaneous associated higher rate mortality morbidity than other intracephalic diseases. The expression levels inflammatory factors have important roles responses indicative changes patient's condition therefore monitoring treatment affected patients at ICU...
Inflammation plays a critical role in the development of cardiac conduction block (CCB), which is associated with an increased risk morbidity and mortality. The monocyte-lymphocyte ratio (MLR) acts as novel inflammatory marker; however, its association CCB has not yet been studied. This study aimed to investigate between MLR risk.In total, 82,472 CCB-free participants were identified from Kailuan study. was calculated using monocyte count/lymphocyte count. stratified based on quartiles...
Objective: This study aimed to explore the impact of a combination hyperuricemia (HUA) and excessive high-sensitivity C-reactive protein (hs-CRP) levels on likelihood developing cardiac conduction block (CCB). Additionally, it sought assess whether influence uric acid (UA) CCB is mediated by hs-CRP. Methods: A prospective was executed utilizing data from Kailuan cohort, including 81,896 individuals initially free CCB. The participants were categorized into four groups depending existence HUA...
The stromal antigen 2 (STAG2) gene encodes a component of the cohesin complex that participates in regulation sister chromatid separation during mitosis. When activated, STAG2 may act as 'caretaker' tumor suppressor gene. As it is unknown whether responsible for occurrence and associated with prognosis acute myeloid leukemia (AML), present study analyzed relative expression levels 127 de novo AML patients 17 healthy volunteers using reverse transcription-quantitative polymerase chain...
This study aimed to investigate the relationship and diagnostic potential between microsatellite instability (MSI) caused by a 9-bp GGGGGTAGA insertion/deletion in mitochondrial DNA (mtDNA) at position 8272 clinical features Chinese patients diagnosed with non-Hodgkin’s lymphoma. The non-d-loop area of locus was detected PCR 139 lymphoma patient samples. found total 16 cases (11.5%), including nine T cell seven B cases. 5-year survival rate 33.3% MSI, 26.7% lacking MSI. In B-cell lymphoma,...