A5043995683- Gout, Hyperuricemia, Uric Acid
- Rheumatoid Arthritis Research and Therapies
- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- Advanced Optical Sensing Technologies
- Central Venous Catheters and Hemodialysis
- Chronic Kidney Disease and Diabetes
- Remote Sensing and LiDAR Applications
- Parathyroid Disorders and Treatments
- Spondyloarthritis Studies and Treatments
- Alcohol Consumption and Health Effects
- Inflammasome and immune disorders
- Cardiovascular Health and Risk Factors
- Genetic and Kidney Cyst Diseases
- Acute Kidney Injury Research
- Cardiovascular Health and Disease Prevention
- Heme Oxygenase-1 and Carbon Monoxide
- Optical Systems and Laser Technology
- Liver Disease Diagnosis and Treatment
- Satellite Image Processing and Photogrammetry
- Inflammatory mediators and NSAID effects
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
Kailuan General Hospital
2013-2024
Shanghai Jiao Tong University
2018-2024
Shanghai First People's Hospital
2014-2024
Wuhan University
2022-2024
Shanghai Institute of Technical Physics
2002-2024
North China University of Science and Technology
2013-2024
University of Chinese Academy of Sciences
2022-2024
Hubei Zhongshan Hospital
2022-2024
Southern Medical University
2024
Nanfang Hospital
2016-2024
Background: Vascular calcification (VC), in which vascular smooth muscle cells (VSMCs) undergo a phenotypic transformation into osteoblast-like cells, is one of the emergent risk factors for accelerated atherosclerosis process characteristic chronic kidney disease (CKD). Phosphate an important regulator VC. Methods: The expression different cell or osteogenesis markers response to high concentrations phosphate exogenous bone morphogenetic protein 2 (BMP-2) was examined by qRT-PCR and western...
Abstract Aims The relationship between uric acid (UA) concentrations and the risk of cardiovascular disease (CVD), especially for subtypes CVD among individuals with chronic kidney (CKD), is not well understood. This study aimed to investigate whether UA concentration was associated all-cause mortality CKD. Methods results A total 27 707 CKD, free at recruitment from Kailuan Study, were included. Cox proportional hazards regression models used compute hazard ratios (HRs) 95% confidence...
Abstract Background Vascular calcification associated with chronic kidney disease (CKD) can increase the risk of mortality. Elevated serum levels high mobility group box 1 (HMGB1) promotes vascular in CKD via Wnt/β-catenin pathway. Sirtuin 6 (SIRT6) prevents fibrosis by blocking expression β-catenin target genes through deacetylation. This study aimed to investigate whether inhibition bone marrow mesenchymal stem cell (BMSC)-derived exosomes is related SIRT6 activity and assess regulatory...
Although keratin 15 (KRT15) has been indicated to be overexpressed in several types of tumor, its role breast invasive carcinoma (BRCA) so far remained elusive. The aim the present study was explore KRT15 expression BRCA based on data obtained from Cancer Genome Atlas and Genotype‑Tissue Expression. compared using a Wilcoxon rank‑sum test. Functional enrichment analysis performed reveal biological roles pathways KRT15. association between immune‑cell infiltration evaluated via single‑sample...
Abstract Background The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories UA and explore its block. Methods A total 67,095 participants a mean age 53.12 years were included from Kailuan cohort in Tangshan, China, who free repeated measurements 2006 2012. during 2012 identified by group-based trajectory modeling. Cox proportional hazard regression models used assess Results categorized three observed...
Intestinal microecology (IM) is the largest and most important microecological system of human body. Furthermore, it key factor for activating maintaining physiological functions intestine. Numerous studies have investigated effects gut microbiota on different tissues organs body as well their association with various diseases, findings are gradually being translated into clinical practice. The affects occurrence, progression, treatment response, toxic side tumors. deepening research related...
Cardiovascular disease (CVD) is a common cause of death in patients with chronic kidney (CKD). Aortic and mitral valve calcification (AVC MVC, respectively) are critical indicators CVD all-cause mortality CKD patients.We conducted single center retrospective study Chinese inpatients to identify risk factors associated (VC).Of 288 enrolled patients, 22.9% had VC, all which exhibited AVC, while 21.2% MVC. The VC group were significantly older than the non-VC (70.42 ± 11.83 vs 56.47 15.00, P <...
Objective Autosomal dominant polycystic kidney disease (ADPKD) is a relentlessly progressing form of chronic for which there no cure. The aim this study was to characterize Chinese patients with ADPKD and identify the factors predict cyst growth renal functional deterioration. Methods To analyze predicting we performed prospective longitudinal observational in cohort 541 an eGFR ≥30 ml/min/1.73 m2. Patients were followed clinically radiologically sequential abdominal magnetic resonance...
Hypertension and enlarged perivascular spaces (EPVS) are thought to be associated with cognitive impairment. However, the correlations among hypertension, EPVS, impairment have not been studied yet. We aimed investigate relationships between cumulative blood pressure (cBP) exposure EPVS whether may mediate relationship cBP impairment.A total of 1507 subjects from Kailuan prospective cohort study were enrolled. was calculated 2006 2022. The effects cBP, scores, evaluated using a logistic...
We examined whether breakfast frequency was associated with chronic inflammatory, as assessed by high-sensitivity C-reactive protein (CRP) concentration.Cross-sectional study.Kailuan community, China.Included were 70 092 Chinese adults without CVD and cancer in 2014 CRP concentrations <10 mg/l, when via a questionnaire, plasma concentration measured.Breakfast (P-trend < 0·001). The adjusted mean 1·33 mg/l (95 % CI 1·23, 1·44) for the 'no breakfast' group 1·07 1·0, 1·14) 'breakfast everyday'...
In neonatal rats, precocious introduction of dietary fructose significantly enhances brush-border transport rates and GLUT-5 mRNA levels during early weaning. this study, these were more than two times higher in the anastomosed intestine compared with those bypassed loop weaning pups that underwent Thiry-Vella surgery consumed high-fructose (HF) diets. fed fructose-free (NF) diets, uptake very low similar to loop. sham-operated littermates, between intestinal regions corresponded loops three...
Ischemia‑reperfusion (I/R) injury of the kidneys is commonly encountered in clinic. The present study assessed efficacy simvastatin preventing I/R‑induced renal a rat model and investigated corresponding molecular mechanisms. Rats were divided into 3 groups, including sham, I/R + group. results revealed that group, levels blood urea nitrogen, serum creatinine lactate dehydrogenase significantly higher than those sham which was inhibited by pre‑treatment. decreased superoxide dismutase...
China's first Mars exploration mission will be implemented in 2020. Scientific objectives and payload configurations are one of the most important top-level designs for mission. The main scientific abroad briefly reviewed. Chinese introduced,and innovation characteristics analyzed.
Abstract Aim The objective of this study was to evaluate the impact rheumatoid arthritis ( RA ) on physical function and health‐related quality life HRQ oL) in China. Method A cross‐section survey conducted 21 general hospitals Eight hundred seven patients were recruited. Data demographics, clinical data, (Stanford Health Assessment Questionnaire Disability Index, HAQ ‐ DI oL (Study Short Form 36 Survey, SF ‐36) collected site. Results In our cohort, impaired 77.6% >0). median...
Longitudinal evidence on change of serum urate level with mortality risk is limited as prior studies have a measurement at single time point. Further, the combined effect and systemic inflammation unknown.
To reduce the harm caused by industrial solid waste to environment, and solve problem of excavated soil disposal in buried pipeline management projects, this study proposes a method produce soil-based controlled low strength materials (CLSM) using wastes (including fly ash red mud) as partial replacements for cement. The properties CLSM were characterized terms flowability, unconfined compressive strength, phase composition microstructure. test results showed that could significantly improve...