A5046403346- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Visual perception and processing mechanisms
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Retinopathy of Prematurity Studies
- Ergonomics and Musculoskeletal Disorders
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Connexins and lens biology
- Ocular Disorders and Treatments
- Pelvic floor disorders treatments
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Corneal Surgery and Treatments
- Tactile and Sensory Interactions
- Urban Green Space and Health
- Urinary Bladder and Prostate Research
He Eye Hospital
2013-2025
Central South University
2016-2025
Hunan Provincial Science and Technology Department
2023-2025
Hubei University of Science and Technology
2017-2025
Anhui Medical University
2025
Jinan University
2024
Hunan Institute of Microbiology
2023
Hefei University of Technology
2022
Sun Yat-sen University
2004-2015
BGI Group (China)
2015
Aim To reassess the association between near work, outdoor exposure and myopia in children through an objective approach. Methods Eighty-six (10.13±0.48 years) were asked to wear Clouclip, a newly developed wearable device that is able measure working distance eye-level illuminance, for complete week obtain information on work exposure. The mean daily Clouclip wearing time was 11.72±1.14 hour. spherical equivalent refraction determined by cycloplegic autorefraction. Results myopic found be...
Purpose To assess the prevalence and risk factors of myopic macular degeneration (MMD) in young middle-aged individuals with high myopia Changsha, central China. Methods A total 445 adults (worse than or equal to −5.0 D) were examined between 2021 2023. Autorefraction biometry using IOLMaster conducted, fundus photos graded for MMD Meta-PM criteria. was diagnosed if category 2, 3, 4 any plus lesion present. Risk such as age, gender, spherical equivalent (SE)/axial length (AL), body mass...
Abstract Purpose: To evaluate the effectiveness of progressive addition lenses (PALs), with a near +1.50 D, on progression myopia in Chinese children. Methods: We enrolled 178 juvenile‐onset acquired myopes (aged 7–13 years, −0.50 to −3.00 D spherical refractive error), who did not have moderately or highly myopic parents, for 2‐year prospective study. They were randomly assigned PAL group single vision (SV) group. Primary measurements, which included and ocular biometry, performed every 6...
Purpose To examine the prevalence of refractive errors in children aged 3–6 years China. Methods Children were recruited for a trial home-based amblyopia screening kit Guangzhou preschools, during which cycloplegic refractions measured both eyes 2480 children. Cycloplegic refraction (from 3 to 4 drops 1% cyclopentolate ensure abolition light reflex) was by autorefraction and retinoscopy. Refractive defined as followed: myopia (at least −0.50 D worse eye), hyperopia +2.00 eye) astigmatism...
We investigated the adaptability and acceptance of a novel spectacle lens design that was recently reported to achieve significant antimyopia effect.A prospective, cross-over study.Twenty children were recruited wear both Defocus Incorporated Multiple Segments (DIMS) single vision (SV) lens, with random assignment which type experienced first. For each high low contrast central distant visual acuity (VA) mid-peripheral near VA measured at 500 lux 50 ambient illuminance after 30 minutes'...
Abstract Purpose: To investigate the possible relationship between myopia progression and near accommodative lag. Methods: A 1‐year longitudinal study was carried out to measure response in 62 children with mild progressing at two visits: they were 10.81 ± 1.60 years old refractive error −1.70 0.76 D on entry. Repeated measurements included error, ocular biometry 33 cm. The determined by autorefraction after cycloplegia; A‐scan ultrasonography; an open‐field autorefractor. Results based...
To investigate the effect of spectral composition and light intensity on refractive development in guinea pigs.One-week-old pigs were randomly assigned to groups exposed broad-spectrum Solux halogen (BS) or spiked-spectrum fluorescent (FL) at both high (Hi, 10,000 lux) low (Lo, 500 intensities under a 12:12 light/dark cycle. Half animals each group used as controls (n = 24, 20, 22, respectively), half fitted with binocular -4-diopter (D) lenses (L, lenses; n respectively). Refractive error,...
Abstract Purpose To determine the efficacy of two myopia control contact lenses (CL) compared with a single‐vision (SV) CL. Methods Ninety‐five Chinese children myopia, aged 7–13 years in 1‐year prospective, randomised, contralateral, cross‐over clinical trial 3 groups; bilateral SVCL (Group I); contralateral wear an extended depth focus (EDOF) CL and II) MiSight® III). In Groups II III, were crossed over at 6‐month point (Stage 1) worn for further 6 months 2). Group I wore during both...
Purpose: To investigate the role of peripheral refraction in children's myopization. Methods: This 2-year study included 214 children (8–15 years old). Refraction across retina (field view: 60° × 36°) was measured with a custom-made aberrometer every year. Three datasets were established: dataset 1, subjects from baseline to first-year visit; 2, 152 second-year and 3, 59 initial emmetropes visit. The different regions correlated central myopic shift, compared among groups levels shift....
Myopia is the second leading cause of visual impairment globally. can induce sight-threatening retinal degeneration and underlying mechanism remains poorly defined. We generated a model myopia-induced early-stage in guinea pigs investigated action. Methods: The form-deprivation-induced myopia (FDM) was induced right eyes 2~3-week-old using translucent balloon for 15 weeks. left eye remained untreated served as self-control. Another group age-matched animals used naïve controls. refractive...
Abstract Introduction: The study aimed to determine the effectiveness of an intervention for unhealthy visual behaviors school-age children using a wearable device (Clouclip). Method: design was self-controlled prospective study. Clouclip, with vibration alert disabled, first applied measure baseline near-work in week. then enabled signal (near-work distance < 30 cm and >5 seconds, or <60 >45 minutes) 3 weeks. Near-work were measured again at week month after intervention,...
To compare light intensity and near-visual tasks objectively between rural urban children.Clouclip, a wearable device, was applied to assess metrics of these two factors in 78 fifth-grade students from an school.The experienced by found significantly lower both the school period (614.05 ± 178.77 vs. 918.41 257.81 lux, P < 0.001) on weekend (444.53 216.65 882.21 536.67 0.001). The duration exposure bright (>1000 lux) also substantially shorter for students. Although no significant difference...
This study aims to explore the role of GABAB receptors in development deprivation myopia (DM), lens-induced (LIM) and hyperopia (LIH). Chicks were intravitreally injected with 25 µg baclofen (GABABR agonist) one eye saline into fellow eye. Choroidal thickness (ChT) was measured via OCT before 2, 4, 6, 8, 24 h after injection. ChT decreased strongly at 6 8 injection returned back baseline level h. Moreover, chicks monocularly treated translucent diffusers, −7D or +7D lenses randomly assigned...
To systematically analysis the burden and trends of blindness vision loss for those aged ≥55 years from 1990 to 2019 predict over next few years.
Abstract Purpose To validate a novel wearable device that can measure both viewing distance and light exposure, Clouclip, compare questionnaire estimates regarding near‐work outdoor time with the objective measures obtained using Clouclip. Methods Fifteen Clouclips were selected to different distances levels of illuminance. With each five measurements at intensities measured recorded. Eighty participants wore for week completed an activity afterwards. Results The intra‐ inter‐Clouclip...
SIGNIFICANCE The spatial frequency spectrum of the environment has been proposed as a risk factor for myopia development. However, this hypothesis not yet directly tested in humans. PURPOSE This study aimed to investigate impact on childhood classrooms with properties resembling those outdoor environments. article describes design, baseline characteristics, and acceptability strategy. METHODS Classrooms had custom-made wallpaper installed forest sky scenes that spectra comparable...
Purpose: Peripheral optics have been suggested to play a role in myopia progression, with accommodation responses also considered potential contributor. This study aimed investigate whether modifications peripheral through different spectacle lenses affect responses. Methods: Dynamic were assessed using double-pass instrument while switching the target from distance (3 m for 3 seconds) near (0.22 m/4.5 D adults, 0.18 m/5.5 children, 5 and then back seconds). Three groups studied. Group 1...