A5100638292- Sepsis Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Appendicitis Diagnosis and Management
- Intestinal Malrotation and Obstruction Disorders
- Intraperitoneal and Appendiceal Malignancies
- Genetic Associations and Epidemiology
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- Retinal Development and Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Adenosine and Purinergic Signaling
- Research in Cotton Cultivation
- Orthopaedic implants and arthroplasty
- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Peptides and Activities
- Cancer Cells and Metastasis
- High Altitude and Hypoxia
- Inflammasome and immune disorders
- Invertebrate Immune Response Mechanisms
- Powder Metallurgy Techniques and Materials
- Plant Molecular Biology Research
- Neurogenesis and neuroplasticity mechanisms
- Neurogenetic and Muscular Disorders Research
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2022-2025
Guangzhou Medical University
2019-2025
Imperial College London
2023-2024
University of Pennsylvania
2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2022-2023
Fudan University
2019-2023
Tang Du Hospital
2023
Air Force Medical University
2023
We previously reported a new line of Shank3 mutant mice which led to complete loss by deleting exons 4-22 (Δe4-22) globally. Δe4-22 display robust ASD-like behaviors including impaired social interaction and communication, increased stereotypical behavior excessive grooming, profound deficit in instrumental learning. However, the anatomical neural circuitry underlying these are unknown. generated with selectively deleted forebrain, striatum, striatal D1 D2 cells. These were used interrogate...
Abstract As an anatomical extension of the brain, retina eye is synaptically connected to visual cortex, establishing physiological connections between and brain. Despite unique opportunity retinal structures offer for assessing brain disorders, less known about their relationship structure function. Here we present a systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. Novel phenotypic links were identified biomarkers function measures derived from...
Background: The gut plays an important role in the development of sepsis and acts as one possible drivers multiple-organ dysfunction syndrome. This study aimed to explore dynamic alterations microbiota its metabolites septic patients at different stages intensive care unit (ICU) admission. Methods: In this prospective observational study, a total 109 fecal samples from 23 patients, 16 nonseptic ICU 10 healthy controls were analyzed. 16S rRNA gene sequencing ultra-performance liquid...
Immune checkpoint inhibitors (ICIs) have significant therapeutic effects but can also cause fatal lung injury. However, the lack of mouse animal models ICI-related injury (ICI-LI) has limited in-depth exploration its pathogenesis. In clinical practice, underlying diseases increase risk Thus, we used a model induced by bleomycin (BLM) and then administered anti-programmed cell death 1 (aPD-1) antibodies to induce ICI-LI. Compared with BLM group, aPD-1 + group presented more weight loss,...
Organ-specific aging clocks have shown promise as predictors of disease risk and trajectories; however, the underlying biological mechanisms they reflect remain largely unexplored. Here, we use large-scale proteomic imaging data to investigate relationships among organ-specific modality-specific uncover processes represent. By estimating paired protein-based imaging-based across 8 major organs, demonstrate that these omics structural profiles exhibit distinct phenotypic genetic signatures,...
Gustatory receptors (GRs) are crucial in the peripheral coding of non-volatile compounds insects, and thus play important roles multiple behaviors including feeding, mating, oviposition. However, little research has been done on GRs lepidopteran pests. In current work with Spodoptera litura, an worldwide crop’s pest, a candidate fructose GR gene (SlitGR8) was cloned full length, its spatial temporal expression profiles were determined by quantitative real-time PCR (qPCR). It revealed that...
The present study aimed to evaluate the influence of biological characteristics hepatocellular carcinoma (HCC) on Liver Imaging Reporting and Data System (LI-RADS) v2017 category contrast-enhanced ultrasound (CEUS) in patients with high risk compare outcomes among different categories after radical resection.Between June 2017 December 2020, standardized CEUS data liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis HCCs...
Alteplase is the only FDA-approved drug for thrombolysis in acute ischemic stroke (AIS). Meanwhile, several thrombolytic drugs are deemed to be promising candidates substitute alteplase. This paper evaluates efficacy and safety of urokinase, ateplase, tenecteplase, reteplase intravenous AIS therapy by computational simulations pharmacokinetics pharmacodynamics combined with a local fibrinolysis model. The performances evaluated comparing clot lysis time, plasminogen activator inhibitor (PAI)...
In this case report, we describe two unusual presentations of varicella-zoster virus (VZV) reactivation without rash, a condition known as Zoster Sine Herpete (ZSH). Case 1, 58-year-old woman presented with severe right-sided chest pain under her breast that radiated to the ipsilateral back. After initial workup ruled out cardiac and musculoskeletal etiologies, characteristic dermatomal distribution made us suspect VZV reactivation. A diagnosis ZSH was positive IgG IgM serologies symptomatic...
The synergistic advantage of combining tissue plasminogen activator (tPA) with pro-urokinase (proUK) for thrombolysis has been demonstrated in several vitro experiments, and a single site proUK mutant (m-proUK) developed better stability plasma. Based on these studies, combination thrombolytic therapy intravenous tPA m-proUK suggested as promising treatment patients ischemic stroke. This paper evaluates the efficacy safety dual by computational simulations pharmacokinetics pharmacodynamics...
Yellow genes are thought to be involved in the melanin biosynthetic pathway and play a crucial role pigmentation reactions insects. However, little research has been done on yellow lepidopteran pests. To clarify function of one ( yellow-y ) Spodoptera litura , we cloned full-length investigated its spatial temporal expression profiles by quantitative real-time PCR (qPCR). It revealed that was highly expressed larva fourth, fifth, sixth instars, as well epidermis (Ep), fat bodies (FB),...
Abstract Acute appendicitis is one of the common acute abdominal diseases in pediatrics. However, implementation radiological examination guided endoscopic retrograde therapy (ERAT) adults limited children. Our previous research explored non-invasive guidance high-frequency ultrasound (HFUS) for ERAT and achieved good therapeutic effects. This study mainly focuses on exploring application value HFUS feasibility assessment children with appendicitis. 163 received by were analyzed...
Sleep is crucial for overall physical and mental health, concerning organs such as the brain, heart, eye, liver, kidney, lung. Nonetheless, a thorough understanding of how sleep relates to these organs, well their genetic bases, remains elusive. Here we conducted systematic mapping sleep-organ connections, focusing on 623 multi-organ imaging biomarkers 10 traits. Both phenotypic analyses uncovered robust associations between structure function multiple brain functions measured by functional...
As large-scale biobanks provide increasing access to deep phenotyping and genomic data, genome-wide association studies (GWAS) are rapidly uncovering the genetic architecture behind various complex traits diseases. GWAS publications typically make their summary-level data (GWAS summary statistics) publicly available, enabling further exploration of overlaps between phenotypes gathered from different cohorts. However, systematically analyzing high-dimensional statistics for thousands can be...
To qualitatively describe bone health changes in children with acute flaccid myelitis (AFM) and assess relationships muscle mass strength functional performance.Retrospective analysis of a cohort 79 AFM seen consecutively one specialized academic center between January 1, 2007, December 31, 2019.Of the participants who were aged 4 months to 21 years old, 41 (52%) had density measured by dual energy absorptiometry (DXA) 32 them (78%) diagnosed low (LBM). We recorded 25 fractures that occurred...
Bray, David; Quillin, Joseph MD; Press, Robert; Yang, Yilin; Wu, Jiayi; Chen, Zhengjia; Eaton, Bree; Olson, Jeffrey J MD Author Information
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant several types of cancer including mesothelioma. Protein kinase CK2 affects pathways through the mechanism phosphorylation. mRNA levels CK2α Gli1 were tested by quantitative RT-PCR immunohistochemistry staining mesothelioma samples lines. Down-regulated expression transcriptional activity demonstrated RT-PCR, Western blot luciferase reporter assay. In this study, we show that...
Abstract Understanding the complex causal relationships among major clinical outcomes and interplay multiple organs remains a significant challenge. By using imaging phenotypes, we can characterize functional structural architecture of human organs. Mendelian randomization (MR) provides valuable framework for inferring causality by leveraging genetic variants as instrumental variables. In this study, conducted systematic multi-organ MR analysis involving 402 traits 372 outcomes. Our revealed...
Abstract Acute appendicitis is one of the common acute abdominal diseases in pediatrics. However, implementation radiological examination guided endoscopic retrograde therapy (ERAT) adults limited children. Our previous research explored non-invasive guidance high-frequency ultrasound(HFUS) for ERAT and achieved good therapeutic effects. This study mainly focuses on exploring application value HFUS feasibility assessment children with appendicitis. 163 received by were analyzed...