A5101838849- Microbial Natural Products and Biosynthesis
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bacterial Genetics and Biotechnology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Orthopedic Surgery and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Silk-based biomaterials and applications
- Lung Cancer Research Studies
- Microbial Metabolism and Applications
- Pharmacological Effects of Natural Compounds
- RNA and protein synthesis mechanisms
- Head and Neck Surgical Oncology
- Fungal Biology and Applications
- Cancer Diagnosis and Treatment
- Cleft Lip and Palate Research
- Glycosylation and Glycoproteins Research
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
First Affiliated Hospital of Guangzhou Medical University
2018-2025
Guangzhou Medical University
2011-2025
State Key Laboratory of Respiratory Disease
2011-2025
Donghua University
2025
Tianjin University of Traditional Chinese Medicine
2022-2024
Central Hospital Affiliated to Shenyang Medical College
2009-2023
Institute of Hematology & Blood Diseases Hospital
2013-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2022
Sixth Affiliated Hospital of Kunming Medical University
2016-2022
Kunming Medical University
2016-2022
Abstract CD19-specific chimeric antigen receptor T cell (CD19 CAR T) therapy has shown high remission rates in patients with refractory/relapsed B-cell acute lymphoblastic leukemia (r/r B-ALL). However, the long-term outcome and factors that influence efficacy need further exploration. Here we report of 51 r/r B-ALL from a non-randomized, Phase II clinical trial (ClinicalTrials.gov number: NCT02735291). The primary shows overall rate (complete or without incomplete hematologic recovery) is...
Lysobacter are ubiquitous environmental bacteria emerging as novel biocontrol agents and new sources of anti-infectives. So far, very little effort has been invested in the study biology these Gram-negative gliding bacteria. Many species characterized by their yellow-orange appearance. Using transposon mutagenesis, we identified a stand-alone polyketide synthase (PKS) gene cluster required for pigment production L. enzymogenes OH11. The yellow pigments were abolished "white" mutants...
TetR family transcriptional regulators (TFRs) are generally found to regulate diverse cellular processes in bacteria, especially antibiotic biosynthesis Streptomyces species. However, knowledge of their function lincomycin S. lincolnensis remains unknown. The present study provides a new insight into the regulation through TFR, SLCG_2919, that directly modulates production and resistance. Intriguingly, SLCG_2919 its adjoining gene, SLCG_2920 , which encodes an ATP/GTP binding protein, were...
Summary The content of bioactive phytochemicals, antioxidant activity and tyrosinase inhibitory the hydroalcoholic extracts Rosa roxburghii were determined. Yellow fruits cultivated R. showed highest phenolic (154.81 mg gallic acid g −1 ), green wild higher flavonoid triterpenoid. from different cultivars maturity stages all demonstrated as good agents inhibitors, with IC 50 value about twice positive standard in DPPH assay triple assay. Nineteen compounds, mainly ellagic acids its...
Immune checkpoint inhibitors (ICIs) have significant therapeutic effects but can also cause fatal lung injury. However, the lack of mouse animal models ICI-related injury (ICI-LI) has limited in-depth exploration its pathogenesis. In clinical practice, underlying diseases increase risk Thus, we used a model induced by bleomycin (BLM) and then administered anti-programmed cell death 1 (aPD-1) antibodies to induce ICI-LI. Compared with BLM group, aPD-1 + group presented more weight loss,...
Pulmonary fibrosis has been characterized by abnormal proliferation of fibroblasts and massive deposition the extracellular matrix, which results from a complex interplay chronic injury inflammatory responses. MicroRNA-301a (miR-301a) is activated multiple stimulators, contributing to tumorigenesis autoimmune diseases. This study showed that miR-301a was overexpressed in bleomycin-induced murine model pulmonary patients with idiopathic (IPF). In addition, transforming growth factor β (TGF-β)...
Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea; however, its biosynthetic cluster lacks regulatory gene, limiting the yield enhancement via regulation engineering of S. erythraea. Herein, six TetR family transcriptional regulators (TFRs) belonging to three genomic context types were individually inactivated in erythraea A226, and one them, SACE_3446, was proved play negative role regulating erythromycin biosynthesis. EMSA qRT-PCR analysis revealed that...
The host tolerance mechanisms to avian influenza virus (H5N1) infection that limit tissue injury remain unknown. Emerging evidence indicates cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent Cl− channel, modulates airway inflammation. Janus tyrosine kinase (JAK) 3, JAK family member plays central role in inflammatory responses, prominently contributes the dysregulated innate immune response upon H5N1 attachment; therefore, this study aims elucidate whether JAK3...
Circular RNAs (circRNAs/circs) have gained attention as a class of potential biomarkers for the early detection multiple cancers. However, functions and mechanisms circRNAs in oncogenesis human colorectal cancer (CRC) remain to be elucidated. The present study aimed investigate roles hsa_circ_0000523 its parental gene methyltransferase-like 3 (METTL3) regulating cell proliferation, apoptosis invasion HCT116 CRC line. To uncover regulated function cells, dual-luciferase reporter assay, flow...
BACKGROUND:Colon adenocarcinoma mostly happens at the junction of rectum and is a common gastrointestinal malignancy. Accumulated evidence has indicated that colon develops by genetic alterations complicated disease. The aim this study was to screen differentially expressed miRNAs (DEMs) genes with diagnostic prognostic potentials in adenocarcinoma. MATERIAL AND METHODS:In we screened DEMs their target (DEGs) between 100 normal samples Cancer Genome Atlas (TCGA) database using DEseq toolkit...
Gastric mucosal injury caused by ethanol is a common gastrointestinal disease. Quinoa (Chenopodium quinoa Willd.), as nutrient-rich grain, plays significant role in preventing and treating gastric damage. The present study aimed to explore the protective effect of on alcohol-induced damage its possible mechanism.The ethanol-induced rat model was used for vivo experiments H2 O2 -induced GES-1 cells vitro elucidate quinoa. results show that water extract can increase superoxide dismutase level...