A5061952583- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Iron oxide chemistry and applications
- Corneal surgery and disorders
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Machine Learning in Bioinformatics
- Magnetic properties of thin films
- RNA Interference and Gene Delivery
- Retinal Development and Disorders
- PARP inhibition in cancer therapy
- Hemoglobin structure and function
- Pancreatitis Pathology and Treatment
- Photosynthetic Processes and Mechanisms
- Metabolism and Genetic Disorders
- Insect-Plant Interactions and Control
- Mitochondrial Function and Pathology
- Connexins and lens biology
- CRISPR and Genetic Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- Ocular Oncology and Treatments
- Retinal Imaging and Analysis
- Thermal Regulation in Medicine
- Magnetic Properties and Synthesis of Ferrites
Penn Presbyterian Medical Center
2011-2024
University of Pennsylvania
2011-2024
Yale University
2002-2021
Indiana University – Purdue University Indianapolis
2020
Aalborg University Hospital
2020
University of North Carolina at Chapel Hill
2018
Fera Science (United Kingdom)
2009-2017
Cork University Hospital
2014
Prince of Wales Hospital
2002-2011
Lawrence Berkeley National Laboratory
2000-2007
Background: The pharmacologic profile of the new proton pump inhibitor esomeprazole has demonstrated advantages over omeprazole that suggest clinical benefits for patients with acid‐related disease. Methods: 1960 endoscopy‐confirmed reflux oesophagitis (RO) were randomized to once daily 40 mg ( n =654) or 20 =656), =650), standard recommended dose RO, up 8 weeks in a US, multicentre, double‐blind trial. primary efficacy variable was proportion healed at week 8. Secondary variables included...
In yeast, the Rad51-related proteins include Rad55 and Rad57, which form a heterodimer that interacts with Rad51. Five human Rad51 paralogs have been identified (XRCC2, XRCC3, Rad51B/Rad51L1, Rad51C/Rad51L2, Rad51D/Rad51L3), each one or more of others. Previously we reported HsRad51 Rad51C Rad51B, HsRad51. Here report in yeast two-hybrid system, Rad51D XRCC2 Rad51C. No other interactions, including self-interactions, were found, indicating observed interactions are specific. The suggesting...
Homologous recombinational repair of DNA double-strand breaks and crosslinks in human cells is likely to require Rad51 the five paralogs (XRCC2, XRCC3, Rad51B/Rad51L1, Rad51C/Rad51L2 Rad51D/Rad51L3), as has been shown chicken rodent cells. Previously, we reported on interactions among these proteins using baculovirus two- three-hybrid yeast systems. To test for involving XRCC3 Rad51C, stable cell lines have isolated that express (His)6-tagged versions or Rad51C. Ni2+-binding experiments...
The depolarization ratio has been measured for several peaks in the resonant Raman spectrum of horse heart ferrocytochrome c (reduced) using six argon and krypton ion laser lines near resonance with β absorption band. is observed to be a strong function frequency so that previous mode symmetry assignments heme proteins based on data at single are unreliable. For anomalously polarized (ρl > 3/4), increases maximum when midway between α bands. These compared theoretical expression...
The purpose of this study was to investigate the association between gender and primary open-angle glaucoma (POAG) among African Americans assess demographic, systemic, behavioral factors that may contribute differences genders. Primary Open-Angle American Glaucoma Genetics (POAAGG) had a case-control design included 35 years older, recruited from greater Philadelphia, Pennsylvania. Diagnosis POAG based on evidence both glaucomatous optic nerve damage characteristic visual field loss....
Identification of the juveniles economically important thrips species on imports by morphology alone can be challenging and culturing is usually required. In case EU quarantine such as Thrips palmi, rapid accurate identification essential. DNA barcoding using Cytochrome oxidase I (COI) gene has become a popular technique for identification; however, in some invertebrate genera COI been shown to provide insufficient variability discrimination. This study presents comparison five different...
Purpose: To determine the risk factors associated with progression to blindness from primary open-angle glaucoma (POAG) in an African-American population.Methods: This study examined 2119 patients enrolled Primary Open-Angle Glaucoma Genetics (POAAGG) study. A total of 59 eyes were identified as legally blind a result POAG (cases) and age-and sex-matched non-blind (controls). Chart reviews performed record known suspected factors.Results: Cases diagnosed at earlier age than controls (p =...
In vertebrates, homologous recombinational repair (HRR) requires RAD51 and five paralogs (XRCC2, XRCC3, RAD51B, RAD51C RAD51D) that all contain conserved Walker A B ATPase motifs. human RAD51D we examined the requirement for these motifs in interactions with XRCC2 RAD51C, survival of cells response to DNA interstrand crosslinks (ICLs). Ectopic expression wild-type or mutants having a non-functional motif was used test complementation rad51d knockout hamster CHO cell line. Although A-motif...
The question of whether DNA obtained from saliva is an acceptable alternative to blood a topic considerable interest for large genetics studies. We compared the yields, quality and performance DNAs mostly elderly study population. Two thousand nine hundred ten primarily subjects (mean age ± standard deviation (SD): 65 12 years), collected Primary Open-Angle African-American Glaucoma Genetics (POAAGG) study, were evaluated by fluorometry and/or spectroscopy. These included 566 2344 saliva....
The magnetic behavior of β-NaFeO2 precipitated in compositions along the Na2SiO3-Fe2O3 join Na2O-Fe2O3-SiO2 system is reported from susceptibility data and Moessbauer studies. anomalous properties observed are discussed terms possibility presence super-paramagnetism.
Fine-particle beta sodium ferrite (β-NaFeO2), rather than α-Fe2O3, may be responsible for superparamagnetic behavior in a glass of composition (in mole fractions) 0.37Na2O-0.26Fe2O3-0.37SiO2. The 700°C isothermal section the phase diagram Na2O-Fe2O3-SiO2 system is given, showing three-phase field bounded by Na2SiO3-NaFeO2-Fe2O3; there no evidence existence (at 700°C) compounds molar 6Na2O-4Fe2O3-5SiO2 or 2Na2O-Fe2O3-SiO2. Moessbauer spectrum β-NaFeO2 has an internal magnetic 487 kOe at room...