A5101514944- Metabolomics and Mass Spectrometry Studies
- AI in cancer detection
- Spectroscopy and Chemometric Analyses
- Traditional Chinese Medicine Analysis
- Machine Learning in Bioinformatics
- Image Retrieval and Classification Techniques
- Traditional Chinese Medicine Studies
- Ginseng Biological Effects and Applications
- Video Surveillance and Tracking Methods
- Face and Expression Recognition
- Medical Image Segmentation Techniques
- Aortic aneurysm repair treatments
- Advanced Vision and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Advanced Chemical Sensor Technologies
- Advanced Image and Video Retrieval Techniques
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Human Pose and Action Recognition
- Remote-Sensing Image Classification
- Anomaly Detection Techniques and Applications
- Computational Drug Discovery Methods
- Forensic Fingerprint Detection Methods
Central South University
2011-2024
Hunan University of Traditional Chinese Medicine
2015-2024
Hunan Academy of Traditional Chinese Medicine
2018-2024
Peking University
2024
Harbin Institute of Technology
2007-2024
Central South University of Forestry and Technology
2024
Jiangxi Normal University
2023
Menlo School
2023
Hunan Agricultural University
2023
Hunan Children's Hospital
2023
Abstract Background Icariin (ICA), an active ingredient extracted from Epimedium species, has shown promising results in the treatment of Alzheimer's disease (AD), although its potential therapeutic mechanism remains largely unknown. This study aimed to investigate effects and underlying mechanisms ICA on AD by integrated analysis gut microbiota, metabolomics, network pharmacology (NP). Methods The cognitive impairment mice was measured using Morris Water Maze test pathological changes were...
Abstract Leukoplakia is the most common premalignant lesion of oral cavity. Epidermal growth factor receptor (EGFR) abnormalities are associated with tumorigenesis and progression. We hypothesized that EGFR expression gene copy number changes predictors risk an (OPL) progressing to squamous cell carcinoma (OSCC). A formalin-fixed, paraffin-embedded OPL biopsy specimen was collected from each 162 patients in a randomized controlled clinical trial. assessed by immunohistochemistry two methods:...
Background: Traditional Chinese medicine (TCM) formulations have proven to be advantageous in clinical treatment and prevention of disease. LiuWei DiHuang Pill (LWDH Pill) is a TCM that was employed treat type 2 diabetes mellitus (T2DM). However, holistic network pharmacology approach understanding the active ingredients therapeutic mechanisms underlying T2DM has not been pursued. Methods: A including drug-likeness evaluation, oral bioavailability prediction, virtual docking, analysis used...
Polygonatum sibiricum polysaccharides (PSP), the extract of sibiricum, are demonstrated to exhibit a wide range pharmacological activities. A recent study reported that PSP alleviated aging kidney and meninges. However, effect on heart remains unclear. The present is aimed at investigating protection D-galactose- (D-gal-) induced aging. Results showed irregularly arranged cardiac muscle fibers were observed in tissues D-gal-treated mice, levels troponin T (cTnT), creatine kinase (CK), p21,...
Anti-aging has attracted worldwide attention. Polygonatum sibiricum polysaccharide (PSP), as the main component of sibiricum, shown good anti-aging activity by regulating gut microbes and relevant metabolites. In this study, we investigated effects PSP based on D-galactose-induced aging model explained its mechanism forming "microbiota-gut-brain" axis. The results showed that could effectively reduce pathological changes oxidative stress in hippocampus, improve cognitive functions. At same...
The early determination of family for a newly found enzyme molecule becomes important because it is directly related to the detail information about which specific target acts on, as well its catalytic process and biological function. Unfortunately, still hard work distinguish classes by experiments. With an enormous amount protein sequences uncovered in genome research, both challenging indispensable develop automatic method fast reliably classifying family. Using concept Chou's pseudo...
The purpose of this study was to evaluate color thyroid elastograms quantitatively and objectively select more effective features differentiate benign from malignant nodules.The approved by the Ethics Committee Harbin Medical University. A total 125 cases (56 69 benign) were analyzed in retrospective study. original transferred red-green-blue space hue-saturation-value space. elasticity information represented hue component elastograms. lesion regions delineated radiologists, statistical...
Type 2 diabetes mellitus (T2DM) is one of the most prevalent endocrine diseases in world. Recent studies have shown that dysbiosis gut microbiota may be an important contributor to T2DM pathogenesis. However, mechanisms underlying roles microbiome and fecal metabolome not been characterized. Recently, Goto-Kakizaki (GK) rat model was developed study clinical symptoms characteristics human T2DM. To further characterize pathogenesis, we combined multi-omics techniques, including 16S rRNA gene...
Zuojinwan (ZJW), a famous Chinese medicine formula, has been widely used to treat colorectal cancer (CRC). However, its bioactive compounds, potential targets, and molecular mechanism remain largely elusive.A network pharmacology-based strategy combined with docking studies in vitro validation were employed investigate of ZJW against CRC.Bioactive compounds targets ZJW, as well related genes CRC, acquired from public databases. Important ingredients, signaling pathways determined through...
In this study, a green and effective extraction method was proposed to extract two main compounds, ginsenosides polysaccharides, from American ginseng by combining deep eutectic solvents (DESs) with aqueous two-phase systems. The factors of type DESs, water content in the solid-liquid ratio, temperature, time were studied extraction. Then, system (DESs-ethylene oxide-propylene oxide (EOPO)) salty solution exchange (EOPO-salty solution) applied for purification polysaccharides....
An approach was proposed to simultaneously solve the classification of varieties and rapid determination TPC in green tea.
Background: Bushen Tiansui Formula (BSTSF) is a traditional formulation of Chinese medicine that has been used to treat Alzheimer’s disease (AD) for decades; however, the underlying mechanisms by which this formula achieves such therapeutic effects have yet be elucidated. Prupose: To investigate neuroprotective BSTSF against AD analyzing metabolite profiles in hippocampus and cortex rats. Methods: The rat models were established injection Aβ 25–35 . Morris water maze (MWM) test was performed...