A5102009587- Metabolomics and Mass Spectrometry Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Gut microbiota and health
- Neonatal Health and Biochemistry
- Trace Elements in Health
- Ginseng Biological Effects and Applications
- Retinal Diseases and Treatments
- Heavy Metal Exposure and Toxicity
- Protease and Inhibitor Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Nutrition, Health and Food Behavior
- Venous Thromboembolism Diagnosis and Management
- Medicinal Plants and Bioactive Compounds
- Platelet Disorders and Treatments
- Inflammasome and immune disorders
- Gastrointestinal motility and disorders
- Mass Spectrometry Techniques and Applications
- Oral health in cancer treatment
- Neurological Complications and Syndromes
- Pharmacological Effects of Natural Compounds
- Inflammation biomarkers and pathways
- Traditional Chinese Medicine Analysis
- Venomous Animal Envenomation and Studies
- Angiogenesis and VEGF in Cancer
Second Military Medical University
2016-2025
Changhai Hospital
2024-2025
Central South University
2014-2024
Shanghai Jiao Tong University
2010-2024
Xiangya Hospital Central South University
2016-2024
National Clinical Research
2024
Bridge University
2024
University of Shanghai for Science and Technology
2024
Guangzhou University of Chinese Medicine
2023
Jiangxi Science and Technology Normal University
2023
Gut microbiota is recognized as an indispensable "metabolic organ" that plays crucial roles in maintaining human health or initiating diseases. Spleen-yang-deficiency syndrome (SYDS) a common of Traditional Chinese Medicine (TCM) clinic. It complex phenotype reflecting the overall changes metabolism which are mainly caused by digestive disorders. However, little known about gut and patients with SYDS, well crosstalk between host metabolism. In current study, integrative metabolic microbial...
Key Points MEKK3 regulates platelet activation through ERK1/2 and JNK2. −/− mice are protected from microthrombosis myocardial infarct expansion post-MI.
Pathological retinal neovascularization (RNV) is one of the leading causes blindness worldwide; however, its underlying mechanism remains unclear. Here, we found that expression endothelial protein C receptor (Epcr) was increased during RNV, and ligand elevated in serum or vitreous body patients with proliferative diabetic retinopathy. Deleting Epcr using an EPCR-neutralizing antibody ameliorated pathological angiogenesis. EPCR promoted heme catabolism carbon monoxide release through...
Determining sensitive biomarkers in the peripheral blood to identify interstitial lung abnormalities (ILAs) is essential for simple early diagnosis of ILAs. This study aimed determine serum metabolic ILAs and corresponding pathogenesis. Three groups subjects undergoing health screening, including healthy subjects, with ILAs, who were initially one year later (Healthy→ILAs), recruited this study. The profiles all subjects’ analyzed by liquid chromatography quadruple time-of-flight mass...
Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin (NaSpTx) Family I. Toxins NaSpTx I share a similar structure, i.e., N-terminal, loops 1–4, and C-terminal. Here, we used Mu-theraphotoxin-Ca2a (Ca2a), isolated from <i>Cyriopagopus albostriatus</i>, as template to investigate the general properties of The interacted with cell membrane prior binding Nav1.7 via hydrophobic residues. Residues loop 1, 4, C-terminal...
Metabolomics is a rapidly growing field in the comprehensive understanding of cellular and organism-specific responses associated with perturbations induced by medicines, chemicals environment. Blood matrices are frequently used clinical biological studies. In this study, we compared metabolic profiling between rat plasma serum using complementary platforms gas chromatography-mass spectrometry (GC-MS) liquid chromatography-quadruple time-of-flight-mass (LC-QTOF-MS). The sample types that...
Background: The contribution of metabolic profile to the cerebral collateral circulation in acute ischemic stroke (AIS) has not been fully outlined. In this study, we conducted a metabolomic study assess relationship between biomarkers and status AIS. Methods: A two-stage was from September 2019 June 2021 our hospital. There were 96 subjects including 66 patients with AIS 30 healthy controls discovery stage 80 53 27 validation stage. Collateral assessed by Tan score based on computed...
Introduction Gestational diabetes (GD) is associated with impaired insulin sensitivity in newborns. Adiponectin and retinol-binding protein 4 (RBP-4) are involved regulating sensitivity. Females more likely to develop at young ages than males. We tested the hypothesis that GD may affect RBP-4 adiponectin levels early life, there be sex-dimorphic associations. Research design methods In a nested case–control study of 153 matched pairs neonates mothers euglycemic pregnancies Shanghai Birth...
To evaluate the status and influential factors for prenatal care postpartum visit among pregnant women in Hunan Province from 2008 to 2013 based on data First Health Service Survey Province. Methods: Based of 2013, proportion women, who didn't meet criteria visit, were calculated (≥5 times ≥2 according National Basic Public program, 2009 Edition). Multivariable logistic regression models used identify influencial factors. Results: A total 1 035 eligible included analysis. The did not 40.12%...
Background: Bilirubin plays a paradoxical role in the pathological mechanism of stroke. To date, few clinical studies have investigated effect serum bilirubin on symptomatic intracranial atherosclerotic stenosis (sICAS). This study aims to evaluate connection between and sICAS. Methods: From September 2015 May 2020, 1,156 sICAS patients without hepatobiliary diseases admitted our hospital were included. Patients distributed into none-mild (0–49%), moderate (50–69%) severe-occlusion groups...
<title>Abstract</title> Pathological retinal neovascularization (RNV) is one of the leading causes blindness worldwide; however, its underlying mechanism remains unclear. Here, we found that expression endothelial protein C receptor (EPCR) was increased during RNV, and ligand elevated in serum or vitreous body patients with proliferative diabetic retinopathy. Deleting <italic>Epcr</italic> using an EPCR neutralizing antibody ameliorated pathological angiogenesis. promoted heme catabolism...
(Abstracted from Int J Gynecol Obstet 2023;162:998–1009 Corpus uteri cancer is the most common gynecologic in Western countries, although globally there large variation its incidence and mortality rate. Risk factors for corpus are giving birth later life, use of contraceptive pills or hormone replacement therapy, alcohol consumption, high weight, adulthood obesity, unhealthy diet, as well comorbidities including diabetes, hypertension, family history endometrial cancer, among others.
OBJECTIVE To observe the effect of electroacupuncture (EA) on expression NF-κB p65 in hippocampus and morphology rats with chronic fatigue syndrome (CFS), so as to explore its mechanism improving cognitive dysfunction CFS. METHODS Forty-eight SD were randomly divided into control, model, EA inhibitor groups (n=12 each group). The CFS model was established by multi-factor compound stress stimulation method. Rats group received (50 Hz, 1 mA) at Baihui (GV20), Emotional Area I bilateral Sensory...
Abstract Background. Although the preparation of lipid nanoparticles (LNPs) achieves great success, their retention highly hydrophobic drugs is still problematic. Results. Herein we report a novel strategy for efficiently loading to LNPs stroke therapy. Oleoylethanolamide (OEA), an endogenous molecule with outstanding neuroprotective effect, was successfully loaded OEA-SPC&DSPE-PEG (OSDP LNPs) drug 15.9 ± 1.2 wt%, four times higher than those prepared via traditional methods. Efficient...