A5100677557- Alzheimer's disease research and treatments
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cholinesterase and Neurodegenerative Diseases
- Immune Cell Function and Interaction
- Neural and Behavioral Psychology Studies
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Plant biochemistry and biosynthesis
- FOXO transcription factor regulation
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Autoimmune Neurological Disorders and Treatments
- RNA Interference and Gene Delivery
- Visual perception and processing mechanisms
Second Xiangya Hospital of Central South University
2018-2025
Central South University
2018-2025
Hangzhou Normal University
2019-2025
Wenzhou Medical University
2025
Shanghai Institute of Nutrition and Health
2024
University of Chinese Academy of Sciences
2024
Zhejiang University
2024
North China Electric Power University
2024
Second Affiliated Hospital of Zhejiang University
2024
National Clinical Research Center for Digestive Diseases
2022-2024
Abstract Background Icariin (ICA), an active ingredient extracted from Epimedium species, has shown promising results in the treatment of Alzheimer's disease (AD), although its potential therapeutic mechanism remains largely unknown. This study aimed to investigate effects and underlying mechanisms ICA on AD by integrated analysis gut microbiota, metabolomics, network pharmacology (NP). Methods The cognitive impairment mice was measured using Morris Water Maze test pathological changes were...
Triggering receptor expressed on myeloid cells-2 (TREM2) is a transmembrane of the immunoglobulin superfamily and crucial signaling hub for multiple pathological pathways that mediate immunity. Although increasing evidence supports vital role TREM2 in tumorigenesis some cancers, no systematic pan-cancer analysis available. Thus, we aimed to explore prognostic value, investigate potential immunological functions, across 33 cancer types. Based datasets from The Cancer Genome Atlas, Cell Line...
Although an intriguing potential association of the gut microbiome with Alzheimer's disease (AD) has attracted recent interest, few studies have directly assessed this relationship or underlying mechanism. Here, we compared microbiota composition and functional differentiation senescence-accelerated mouse prone 8 (SAMP8) mice control resistant 1 (SAMR1) using 16S rRNA gene metagenomic sequencing analysis, respectively. Specifically, results showed that SAMP8 displayed a characteristic...
Type 2 diabetes mellitus (T2DM) is one of the most prevalent endocrine diseases in world. Recent studies have shown that dysbiosis gut microbiota may be an important contributor to T2DM pathogenesis. However, mechanisms underlying roles microbiome and fecal metabolome not been characterized. Recently, Goto-Kakizaki (GK) rat model was developed study clinical symptoms characteristics human T2DM. To further characterize pathogenesis, we combined multi-omics techniques, including 16S rRNA gene...
Zuojinwan (ZJW), a famous Chinese medicine formula, has been widely used to treat colorectal cancer (CRC). However, its bioactive compounds, potential targets, and molecular mechanism remain largely elusive.A network pharmacology-based strategy combined with docking studies in vitro validation were employed investigate of ZJW against CRC.Bioactive compounds targets ZJW, as well related genes CRC, acquired from public databases. Important ingredients, signaling pathways determined through...
Ischemic stroke is a serious health hazard that lacks effective treatment strategies. This study aims to investigate baicalin’s effect on tight junctions and immune cell infiltration after ischemic injury. Rat brain microvascular endothelial cells (BMECs) were treated with OGD/R establish an in vitro model. Caspase-3, Bax, Bcl-2, zonula occludens-1 (ZO-1), occludin, claudin-5, tumor necrosis factor (TNF)-[Formula: see text], interleukin (IL)-6, inducible nitric oxide synthase (iNOS),...
In the R programming language, de facto standard framework for drawing rectangular coordinates is ggplot2. The most important feature of ggplot2 that it object-oriented and uses plus sign to overlay various objects. field circular visualization, circlize a popular software, but based on procedural programming. Making can make logic written code clearer improve reusability code. this work, we introduce circlizePlus, which redesigns concepts in visualization into several S4 classes. It also...
Traditional Chinese medicine has been utilized for the treatment of cancer. Jianpi Jiedu decoction (JPJD), a traditional formula, used colorectal cancer decades. However, underlying molecular mechanistic basis effect JPJD on is poorly understood.The aim this study was to identify effects human colon cells in vitro as well vivo and investigate anticancer JPJD.The antitumor activity assessed by MTT assay, flow cytometric analysis, wound-healing transwell assays, tube formation assays order...
Background: Bushen Tiansui Formula (BSTSF) is a traditional formulation of Chinese medicine that has been used to treat Alzheimer’s disease (AD) for decades; however, the underlying mechanisms by which this formula achieves such therapeutic effects have yet be elucidated. Prupose: To investigate neuroprotective BSTSF against AD analyzing metabolite profiles in hippocampus and cortex rats. Methods: The rat models were established injection Aβ 25–35 . Morris water maze (MWM) test was performed...
Quercetin (QUE) is a bioactive component that belongs to the natural flavonoids group, and recent researchers found it could prevent colorectal cancer (CRC). However, exact mechanism by which QUE exerts its anti-tumor effects in CRC remains unclear. In this study, MTS assay flow cytometry were used detect of on HCT-116 cells. The results showed inhibit proliferation induce apoptosis Furthermore, whole transcriptome sequencing was employed establish microRNA (miRNA), long non-coding RNA...
Colorectal cancer (CRC) is a commonly occurring tumour with poor prognosis.Autophagy-related long non-coding RNAs (lncRNAs) have received much attention as biomarkers for prognosis and diagnosis.However, few studies focused on their prognostic predictive value specifically in CRC.This research aimed to construct robust autophagy-related lncRNA signature CRC.Autophagy-related lncRNAs from The Cancer Genome Atlas database were screened using univariate Cox, LASSO, multivariate Cox regression...
Bushen Tiansui Formula (BSTSF) is a traditional Chinese medicine prescription. It has been widely applied to treat Alzheimer’s disease (AD) in the clinic; however, mechanisms underlying its effects remain largely unknown. In this study, we used rat AD model study of BSTSF on cognitive performance, and UPLC-MS/MS-based metabolomic lipidomic analysis was further performed identify significantly altered metabolites cerebral cortices rats determine profiles these animals. The results revealed...
Background The Polygenic Score (PGS) Catalog is a public database dedicated to storing polygenic risk scores. To date, the has included 5,022 scores associated with 656 different traits. Although PGS offers an official resource representational state transfer (REST) application programming interface (API), there no ready-made data client tailored for any specific language. Researchers are thus required invest time in becoming familiar structure of REST API and implement corresponding their...