A5102806845- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Respiratory Support and Mechanisms
- NF-κB Signaling Pathways
- S100 Proteins and Annexins
- Neonatal Respiratory Health Research
- Chemokine receptors and signaling
- Neuroendocrine Tumor Research Advances
- Antimicrobial Peptides and Activities
- Cancer therapeutics and mechanisms
- Nitric Oxide and Endothelin Effects
- Immune cells in cancer
- Lung Cancer Research Studies
- IL-33, ST2, and ILC Pathways
- Advanced Glycation End Products research
- Inflammatory mediators and NSAID effects
- Thermal Regulation in Medicine
Xiangya Hospital Central South University
2013-2024
Central South University
2013-2024
Abstract Neutrophil extracellular traps (NETs) facilitate the killing of pathogens. However, excessive NETs formation and poor degradation are associated with exacerbated immune responses tissue injury. In this study, we investigated role in lipopolysaccharide (LPS)-mediated acute lung injury (ALI) assessed use DNase I, for treatment ALI. Additionally, focused on controversial issue whether LPS directly induces release vitro . was detected murine ALI vivo increased markers,...
The pathogenesis of ventilator-induced lung injury (VILI) is associated with neutrophils. Neutrophils release neutrophil extracellular traps (NETs), which are composed DNA and granular proteins. However, the role NETs in VILI remains incompletely understood. Normal saline deoxyribonuclease (DNase) were used to study VILI. To further determine Toll-like receptor 4 (TLR4) NETosis, we evaluated NET formation TLR4 knockout mice wild-type that mechanically ventilated. Some measures markers...
Abstract This single-arm, multi-center clinical trial aimed to evaluate the safety, tolerability, DLT, recommended dose (RD), preliminary efficacy, and pharmacokinetics (PK) characteristics of lurbinectedin, a selective inhibitor oncogenic transcription, in Chinese patients with advanced solid tumors, including relapsed SCLC. Patients tumors were recruited dose-escalation stage received lurbinectedin 3 + design (two cohorts: 2.5 mg/m 2 3.2 , IV, q3wk). The RD was expanded following...
Histones are intracellular nucleosomal components and extracellular damage-associated molecular pattern molecules that modulate chromatin remodeling, as well the immune response. However, their roles in cell migration invasion remain undefined. Here, we demonstrate histones novel regulators of tumor metastasis with chemokine-like activities. Indeed, exogenous promote both hepatocellular carcinoma (HCC) through toll-like receptor (TLR)4, but not TLR2 or for advanced glycosylation end product....
Nerve growth factor (NGF) plays an important role in asthmatic inflammatory responses. However, the effects of NGF on dendritic cells (DCs) inflammation remain unknown. Therefore, we examined co-stimulatory molecules and release cytokines after ovalbumin (OVA) a low dose LPS (low LPS) stimulation cells.Bone-marrow-derived (BMDCs) were collected from 6- to 8-week-old wide or TLR4(-/-) mice. BMDCs treated with OVA and/or for 12h, then stimulated 24h. ELISA flow cytometry performed measure...
IL-33 and WNT1-inducible secreted protein (WISP1) play central roles in acute lung injury (ALI) induced by mechanical ventilation with moderate tidal volume (MTV) the setting of sepsis. Here, we sought to determine inter-relationship between WISP1 associated signaling pathways this process.We used a two-hit model cecal ligation puncture (CLP) followed MTV (4 h 10 mL/kg) wild-type, IL-33-/- or ST2-/- mice wild-type treated intratracheal antibodies WISP1. Macrophages (Raw 264.7 alveolar...