A5076834193- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Alcohol Consumption and Health Effects
- Gout, Hyperuricemia, Uric Acid
- Breast Cancer Treatment Studies
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Gene expression and cancer classification
- Immune cells in cancer
- Migraine and Headache Studies
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
- Hepatocellular Carcinoma Treatment and Prognosis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastrointestinal disorders and treatments
- Single-cell and spatial transcriptomics
- Cardiovascular Health and Risk Factors
- Circular RNAs in diseases
- Ultrasound and Hyperthermia Applications
First Affiliated Hospital of Soochow University
2019-2025
Zhengzhou People's Hospital
2025
Henan Provincial People's Hospital
2025
Zhengzhou University
2021-2025
Soochow University
2019-2025
Tangshan Gongren Hospital
2023-2025
Chengdu University of Traditional Chinese Medicine
2008-2024
Nanjing Xiaozhuang University
2024
First Affiliated Hospital of Zhengzhou University
2016-2024
Shandong First Medical University
2024
The overall biological role and clinical significance of long non-coding RNA H19 in colorectal cancer (CRC) remain largely unknown. Here, we firstly report that the lncRNA recruits eIF4A3 promotes CRC cell proliferation. We observed higher expression was significantly correlated with tumor differentiation advanced TNM stage a cohort 83 patients. Multivariate analyses revealed served as an independent predictor for survival disease-free survival. Further experiments overexpression promoted...
Non-small cell lung cancer (NSCLC) is the most commonly diagnosed and associated with poor prognosis. This study aimed to analyze if serum C-reactive protein (CRP), albumin (Alb), CRP/Alb ratio could provide prognostic information in patients NSCLC. 387 primary NSCLC were included this analysis. Cox proportional hazards regression was used estimate hazard (HR) 95% confidence interval (CI) of death adjustment for some potential confounders. The multivariate analyses revealed statistically...
Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value PD-L1 cervical cancer is still controversial. Therefore, we carried meta-analysis investigate and clinicopathological impact cancer. A comprehensive literature search was performed PubMed, Embase, Web Science, Cochrane Library. The correlation between overall survival (OS), progression-free (PFS), features analyzed by hazard ratios...
Previous studies on alcohol consumption and incident gout have mostly included men or combined both sexes, the sex-specific associations between are poorly understood.
Alterations in microRNA (miRNA) expression patterns have been associated with a number of human diseases. Accurate quantitation miRNA levels is important for their use as biomarkers and determining functions. Although the issue proper detection was solved introduction standard reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) assays, numerous issues selection appropriate internal control genes remain. U6 (RNU6‑1) snRNA, most commonly used gene RT‑qPCR shown to be...
Introduction. The oral cavity is one of the largest reservoirs microorganisms and many pathogenic bacteria have been shown to be associated with aetiology cancers. Gap Statement. Owing complexity microbial communities their unclear relationship cancer, identification specific which contribute cancer a key imperative. Aim. To compare investigate variations in composition bacterial microbiome its functions between patients tumorous lesions healthy subjects. Methodology. Twenty-seven samples...
Scope Lactoferrin (Lf) possess a protective potential to liver, but whether it can prevent alcoholic liver injury (ALI) remains unclear. Methods and Results Four groups of male C57BL/6J mice are fed with different diets, namely, AIN‐93G diet for control (CON) ethanol (EtOH) groups, 0.4% 4% casein replaced by Lf low‐dose (LLf) high‐dose (HLf) respectively. ALI is induced giving 20% ad libitum combined four “binges”. remarkably decrease EtOH‐induced mortality. promotes aldehyde dehydrogenase‐2...
Abstract The Naples prognostic score (NPS) is an effective inflammatory and nutritional scoring system widely applied as a factor in various cancers. We aimed to analyze the value of NPS patients diagnosed with non-small-cell lung cancer (NSCLC). prospectively collected 395 NSCLC between January 2016 December 2018 two university-affiliated hospitals. Patients were divided into three groups according their pretreatment (Group 0: = 0; Group 1: 1–2; 2: 3–4). Kaplan–Meier survival curves...
Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains major challenge. Herein, we applied two algorithms to uncover the landscape of microenvironment 491 HCC patients. Three patterns were defined using CIBERSORT method, cell (ICI) scores established principal component analysis. In high ICI score group, activation Wnt/β-catenin...
The progression of cancer is accompanied by the acquisition stemness features. Many evaluation methods based on transcriptional profiles have been presented to reveal relationship between and cancer. However, instead absolute index values-the values with certain range-these gave without range, which makes them unable intuitively evaluate stemness. Besides, these indices were expression genes, found be seriously influenced batch effects composition samples in dataset. Recently, we showed that...
Background: Whether lifestyle factors are similarly associated with risk of heart failure (HF) for individuals different metabolic or genetic status remains unclear. Methods: We included 464 483 participants from UK Biobank who were free major cardiovascular disease HF during baseline recruitment. Healthy avoidance smoking, no obesity, regular physical activity, and healthy diet. Lifestyle was categorized as favorable (3 4 factors), intermediate (2 unfavorable (0 1 factor) lifestyles....
Objective: To explore the construction and clinical value of a predictive model for malignant ventricular arrhythmias (MVA) in children with viral myocarditis (VMC) based on parameters repolarization heterogeneity. Methods: We retrospectively analyzed 99 VMC admitted to Henan Provincial People's Hospital from January 2019 February 2023 as training set, 38 March May 2024 external validation set cross-sectional study. Patients were divided into MVA non-MVA groups occurrence MVA. measured QT...
Background: Genetic and environmental factors contribute to migraine the comorbidities of anxiety depression. However, association between genetic polymorphisms in transient receptor potential (TRP) channels glutamatergic synapse genes with risk depression remain unclear. Methods: 251 patients containing 49 112 600 controls were recruited. A customized 48-plex SNPscan kit was used for genotyping 13 SNPs nine target genes. Logistic regression conducted analyze these SNPs’ susceptibility...
Astrocytes play an important role in the pathogenesis of Alzheimer's disease (AD). It is widely involved energy metabolism brain by providing nutritional and metabolic support to neurons; however, alteration astrocytes AD remains unknown. Through integrative analysis single-nucleus sequencing datasets, we revealed changes various cell types prefrontal cortex patients with AD. We found depletion some metabolites (acetyl-coenzyme A, aspartate, pyruvate, 2-oxoglutarate, glutamine, others), as...
Lipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for cardiovascular disease (CVD), while its potential interplay with family history (FHx) of CVD, measure both genetic and environmental exposures, remains unclear. We examined the associations Lp(a) in terms circulating concentration or polygenetic risk score (PRS), FHx CVD incident heart failure (HF). Included were 299,158 adults from UK Biobank without known HF at baseline. Hazards ratios (HRs) 95% Cls estimated by Cox...
Hepatocellular carcinoma (HCC) is one of the most common malignancies, and therapeutic outcome remains undesirable due to its recurrence metastasis. Gene dysregulation plays a pivotal role in occurrence progression cancer, molecular mechanisms are largely unknown.The differentially expressed genes HCC screened from GSE39791 dataset were used conduct weighted gene co-expression network analysis. The selected hub validated Cancer Genome Atlas (TCGA) database 11 datasets Expression Omnibus...
Background The aim of this study was to evaluate whether the efficacy and safety PD-1 inhibitors combined with chemotherapy in treatment patients esophageal squamous cell carcinoma (ESCC) distant metastasis real world are as effective safe clinical trials. Patients methods From July 2019 2023, a total 422 ESCC were included divided into inhibitor group (PC group) alone (C according regimen. There 278 PC 144 C group. primary endpoint progression-free survival (PFS), while secondary endpoints...
Background: Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a unique subtype of this disease. Few studies focus on the feasibility trastuzumab as maintenance or palliative therapy for patients with HER2-positive advanced GC. Patients and methods: We retrospectively analyzed data 11 patients, evaluated efficacy safety trastuzumab, attempted to investigate prognostic factors treatment. Among one achieved partial response (PR), six stable disease (SD), four were...