A5001084425- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- CNS Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Lesions and Carcinomas
- Kruppel-like factors research
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Chronic Myeloid Leukemia Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Tumors Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Neuroendocrine Tumor Research Advances
- Multiple Myeloma Research and Treatments
- Vascular Tumors and Angiosarcomas
National Taiwan University
2015-2025
National Taiwan University Hospital
2016-2025
Shanghai Cell Therapy Research Institute
2024
Institute of Clinical Research
2021
University of Minnesota Rochester
2015
Emory University
2015
Academia Sinica
2015
Royal Alexandra Hospital
2015
University of Alberta
2015
Mayo Clinic in Arizona
2015
Abstract In 2022, two novel classification systems for myelodysplastic syndromes/neoplasms (MDS) have been proposed: the International Consensus Classification (ICC) and 2022 World Health Organization (WHO-2022) classification. These contemporary exhibit numerous shared features but also diverge significantly in terminology definition of new entities. Thus, we retrospectively validated ICC WHO-2022 found that both promoted efficient segregation this heterogeneous disease. After examining...
PURPOSE Durable partial response (PR) and durable stable disease (SD) are often seen in patients with hepatocellular carcinoma (HCC) receiving atezolizumab plus bevacizumab (atezo-bev). This study investigates the outcome of these histopathology residual tumors. PATIENTS AND METHODS The IMbrave150 study's atezo-bev group was analyzed. PR or SD per RECIST v1.1 lasting more than 6 months defined as durable. For histologic analysis, a comparable real-world from Japan Taiwan who had undergone...
632 Background: Nectin cell adhesion protein 4 (Nectin-4) is overexpressed in various malignancies, contributing to cancer progression and poor prognosis. We aimed assess Nectin-4 expression hepatocellular carcinoma (HCC). Methods: Patients who underwent primary liver tumor resection for HCC upon initial diagnosis at National Taiwan University Hospital 2019 were included. Exclusion criteria consisted of prior systemic or loco-regional therapy, death within three months post-surgery....
RNF43 is an E3 ligase that suppresses the Wnt/β-catenin signaling pathway and frequently mutated in microsatellite-unstable colorectal carcinoma. To investigate pathogenetic role of serrated pathway, we conducted mutation analysis several types neoplasms. was found 2 20 (10%) sessile adenomas, 10 36 (28%) traditional 7 37 (19%) adenomas with cytologic dysplasia, 9 31 (29%) BRAF-mutated/microsatellite-stable carcinomas; however, no 30 tubulovillous/villous adenomas. All mutations were located...
Background Light chain deposition disease (LCDD) is usually a systemic disorder characterised by non-amyloid monoclonal immunoglobulin light in tissues. Localised nodular pulmonary (NP) LCDD rare and poorly entity and, owing to the difficulties diagnosis, limited data are available. Methods We investigated clinical, radiological pathological characteristics of series six confidently diagnosed cases NPLCDD. Results There were three men women with ages ranging from 33 74 years. In all there...
Abstract The mechanisms or host factors involved in septic thrombus vegetation formation Staphylococcus aureus-induced infective endocarditis (IE) are unclear. Using an experimental rat model, here we demonstrated that S. aureus HG001-induced was composed of bacterial floes encased aggregated platelets and surrounded by neutrophil extracellular traps (NETs). In vitro data contribute to both biofilm NET formation. Prophylactic administration DNase I significantly reduced the size induced...
RNF43 is a tumour suppressor gene that suppresses the Wnt-β-catenin signalling pathway. We investigated role of in intraductal papillary neoplasm bile duct (IPNB).We conducted mutation analysis 50 IPNBs, and identified six (12%) mutations. was more frequent intestinal subtype IPNB (17%) than gastric/pancreatobiliary (5%). There strong association with GNAS (P = 0.007) mutation, borderline correlation KRAS 0.074) mutation. The presence macroscopic mucin hypersecretion closely related to...
Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2 plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson-Forssman-Lehmann syndrome, congenital neurodevelopmental disorder. Loss-of-function are detected in patients with acute leukemia, mainly T-cell lineage and small proportion myeloid lineage. The functions physiological hematopoiesis leukemogenesis remain incompletely defined. To address this question, we generated conditional Phf6...
ABSTRACT Various prognostic scoring systems in myelofibrosis (MF) have been developed to guide clinical decision‐making MF. However, discrepancies between different for individual patients remain poorly understood, which can result conflicting treatment recommendations. Moreover, data regarding there applicability Asian populations scarce. We conducted a retrospective analysis of with overt MF at National Taiwan University Hospital from November 1, 2006, 30, 2023. This study evaluates the...
Background: Intensive consolidation treatment following high-dose methotrexate (HDMTX)-based chemotherapy is recommended for fit patients with primary central nervous system lymphoma (PCNSL). Otherwise, HDMTX maintenance might be a useful alternative to approach in certain circumstances. However, the real-world evidence supporting beneficial role of or PCNSL limited. Methods: We retrospectively analyzed clinical efficacy and survival impact on treated HDMTX-based induction chemotherapy....
Abstract Background Tissue factor (TF)-rich cancer microvesicles are correlated with thrombosis risk. Intrinsic coagulation factors also associated the risk of in patients. This study explored roles pancreatic cancer-derived and intrinsic thrombogenesis. Methods Human cell lines rich TF (AsPC-1-TF high , MIAPaCa-2-TF ) or poor [AsPC-1-TF KO (knockout) low ] were generated for microvesicle preparation injected into coagulation-defective mice. Inferior vena cava (IVC) clots lung evaluated....
Summary Dedicator of cytokinesis 1 ( DOCK1 ), a guanine nucleotide exchange factor for the small GTPase Rac, has been implicated in various biological processes, but its pathological roles acute myeloid leukaemia (AML) remain unexplored. In this study, we analysed clinical impacts expression 341 patients with de novo non‐M3 AML treated standard chemotherapy. The results showed that high is an independent adverse prognostic factor. Consistent this, experiments using cell lines, xenografts and...
To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan association with human immunodeficiency virus (HIV), herpesvirus 8 (HHV8) Epstein-Barr (EBV).We investigated retrospectively 26 cases a median age 76.5. Only one (4%) patient was infected HIV. Cytologically, all cells revealed typical immunoblastic to plasmablastic morphology. Immunohistochemically, HHV8 positive eight (32%) tumours negative 17 (68%) cases. All 23 tested examined were...
Anti-programmed death-1 therapy has poor efficacy in mismatch repair-proficient (pMMR) colorectal cancers; however, its pMMR gastric cancers remains undetermined. Here, we report the case of a patient with and microsatellite-stable cancer who exhibited partial response to salvage anti-programmed pembrolizumab. Initially, underwent subtotal gastrectomy 4 years ago for early-stage (pT1bN2M0, stage IIA). Immunohistochemical analysis tumor revealed strongly positive HER2/neu. He had received...
Primary intestinal T-cell lymphoma (PITL) is highly aggressive and includes celiac disease–related enteropathy-associated (EATL), monomorphic epitheliotropic (MEITL), primary peripheral lymphoma, not otherwise specified (ITCL-NOS). MEITL the most common PITL in Asia, comprising of medium-sized cells typically expressing CD8, CD56, cytotoxic granules. Occasional cases with intermediate features between ITCL-NOS are difficult to be classified warrant further investigation. We collected 54...
Patients with diffuse large B-cell lymphoma (DLBCL) concurrent hepatitis B surface antigen (HBsAg)-positive virus (HBV) infection have distinct clinical features. Nevertheless, the prognostic value of HBsAg in DLBCL rituximab era remains unclear.We conducted a retrospective cohort study to investigate relevance immunocompetent patients treated homogeneous plus cyclophosphamide, doxorubicin, vincristine, and prednisone between 2002 2016.Among 416 analyzed patients, 98 (23.6%) were positive....
A robust morphomolecular classification system for gastric carcinoma is required. 4-tier morphologic proposed, including diffuse, intestinal, tubular, and lymphoid types. tissue microarray mismatch repair immunohistochemistry Epstein-Barr virus (EBV) in situ hybridization were performed 329 carcinomas. DNA flow cytometry was used to detect aneuploidy formalin-fixed paraffin-embedded samples. Lymphoid histology the third most common histologic pattern at our institute strongly associated with...
The role of gut microbiota in host defense against nontuberculous mycobacterial lung disease (NTM-LD) was poorly understood. Here, we showed significant dysbiosis patients with NTM-LD. Reduced abundance
To describe the clinical and histologic characteristics of ocular surface squamous neoplasia (OSSN) evaluate factors significant in recurrence at a university hospital North Taiwan. Patient charts, features, pathology records were retrospectively reviewed patients with pathology-proved OSSN from January, 1994 to December, 2014. Clinicopathologic correlation was analyzed. Thirty-six recruited. Mean age 63.4 ± 13.0 (ranging 23 87) years old. predominant men (21/36). Clinical appearances...