A5007182076- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Vascular Tumors and Angiosarcomas
- Hemoglobinopathies and Related Disorders
- Glioma Diagnosis and Treatment
- Digital Imaging for Blood Diseases
- Mycobacterium research and diagnosis
- Histone Deacetylase Inhibitors Research
- Cytomegalovirus and herpesvirus research
- Eosinophilic Disorders and Syndromes
- RNA Research and Splicing
National Taiwan University Hospital
2016-2025
National Taiwan University
2016-2025
Sir Run Run Shaw Hospital
2025
Zhejiang University
2025
Tongji University
2025
Key Laboratory of Guangdong Province
2025
Shantou University
2025
United Imaging Healthcare (China)
2023
Kanazawa University Hospital
2022
Stanford University
2022
Many randomised controlled trials have been conducted in China to evaluate the effectiveness of traditional Chinese medicine, but much information is inaccessible Western doctors. We estimated total number published and identified problems applying such methodology evaluation which would serve as preparatory work for systematic review dissemination evidence medicine. We randomly selected 28 journals using stratified sampling from a 100 medicine (4 national, 10 university, provincial or...
Abstract Purpose: The transcription factor CCAAT/enhancer binding protein α, encoded by the CEBPA, is crucial for differentiation of immature granulocytes. Mutation CEBPA may play an important role in leukemogenesis and prognosis. We sought to characterize mutation acute myeloid leukemia (AML) clarify if there a distinct immunophenotype leukemic cells with mutation. Experiment Design: One hundred four patients de novo AML were evaluated cells. Results: Twenty-two mutations identified 16...
Abstract BACKGROUND Sinonasal natural killer (NK)/T‐cell or T‐cell lymphoma behaves quite differently from other lymphomas. The objective of this study was to investigate clinical features, treatment outcomes, and failure patterns in patients with type sinonasal lymphoma. METHODS From September, 1977 December, 2000, 77 NK/T‐cell who had received radiotherapy (R/T), chemotherapy (C/T), both (R/T C/T) were evaluated retrospectively. RESULTS Fifty‐six (73%) locoregional disease only, 21 (27%)...
Abstract Nucleophosmin (NPM) mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially those normal karyotype. These results provide basis for studies the pathogenesis this specific subgroup AML. In study, NPM were analyzed 173 Chinese patients AML, including and children. We that present 19.1% overall population 40.3% Adults had significantly higher incidence than children [32 126 (25.4%) versus 1 47 (2.1%), P < 0.001]....
Abstract The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this during clinical course remains unclear. In study, mutations were identified 7% 500 de novo AML and 58.8% CK. closely associated older age, lower white blood cell (WBC) platelet counts, FAB M6 subtype, unfavorable-risk cytogenetics CK, negatively NPM1 mutation, FLT3/ ITD DNMT3A mutation. Multivariate analysis demonstrated that was an independent...
Abstract Background Risk factors and outcomes in hematological patients who acquire invasive fungal sinusitis (IFS) are infrequently reported the modern medical era. Method A retrospective study of hospitalized with disease was conducted at National Taiwan University Hospital between January 1995 December 2009. Results Clinical characteristics their associated radiographic microbiological findings were analyzed. Forty-six IFS 64 chronic non-invasive enrolled as comparsion. developed more...
Abstract A set of myelodysplasia-related (MDS-R) gene mutations are incorporated into the 2022 European LeukemiaNet risk classification as adverse genetic factors for acute myeloid leukemia (AML) based on their poor prognostic impact older patients. The these younger patients (age < 60 years) remains elusive. In study 1213 with de novo non-M3 AML, we identified MDS-R in 32.7% total cohort, 44.9% and 23.4% had a significantly lower complete remission rate both age groups. With median...
The European LeukemiaNet (ELN) recently proposed a revised recommendation for the diagnosis and management of acute myeloid leukemia (AML) in adults, recognized as ELN-2022. However, validation large real-world cohort remains lacking. In this study, we aimed to validate prognostic relevance ELN-2022 809 de novo, non-M3, younger (ages 18-65 years) AML patients receiving standard chemotherapy. risk categories 106 (13.1%) were reclassified from that determined using ELN-2017 effectively helped...
Abstract In 2022, two novel classification systems for myelodysplastic syndromes/neoplasms (MDS) have been proposed: the International Consensus Classification (ICC) and 2022 World Health Organization (WHO-2022) classification. These contemporary exhibit numerous shared features but also diverge significantly in terminology definition of new entities. Thus, we retrospectively validated ICC WHO-2022 found that both promoted efficient segregation this heterogeneous disease. After examining...
Introduction Propofol is a fast-acting intravenous anaesthetic widely used for sedation and anaesthesia in gastrointestinal endoscopy, bronchoscopy, the induction/maintenance of general outpatients inpatients; however, propofol has several undesirable effects, including injection pain, which affects physical mental health patients, cardiopulmonary depression, characterised by hypotension, bradycardia apnea, commonly occur clinical practice. Ciprofol (HSK3486) analogue with good safety, high...
To investigate the time sequence of occurrence p15 INK4B gene methylation in myelodysplastic syndrome (MDS) and its correlation with leukaemic transformation survival patients, status promoter region was analysed 50 patients serially studied 22 them. Of 17 (34%) showed methylation, first demonstrated at diagnosis or during follow‐up. When FAB subtypes study were used analysis, incidence each risk group MDS remained stable throughout course: 0% for low‐risk [refractory anaemia (RA) RA ring...
Summary Mutations of Runt‐related transcription factor 1 ( RUNX1 ) have been detected in patients with myelodysplastic syndrome (MDS). However, the prognostic implication mutations primary MDS is limited. The stage disease at which are acquired and whether they persist during course also remain unclear. We analysed exons 3–8 132 correlated results clinical features. Serial studies were performed follow‐up period. Sixteen (12%) had time diagnosis. All that diagnosis remained unchanged course....
Seven relapsed and/or refractory acute promyelocytic leukaemia patients were treated by arsenic trioxide (As 2 O 3 ). Four (4/7, 57%) achieved complete remission after one to three cycles of treatment and the most common side‐effect was fluid retention (in six patients, 86%), including weight gains pleuro‐pericardial effusions. Evident polyneuropathy compatible with chronic toxicity noted in two who received As maintenance therapy them had marked distal muscular atrophy. We suggest that may...