A5103028662- Asthma and respiratory diseases
- Acute Myeloid Leukemia Research
- Bariatric Surgery and Outcomes
- Central Venous Catheters and Hemodialysis
- Allergic Rhinitis and Sensitization
- Pneumonia and Respiratory Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Air Quality and Health Impacts
- Vascular anomalies and interventions
- Receptor Mechanisms and Signaling
- Mast cells and histamine
- Body Contouring and Surgery
- Food Allergy and Anaphylaxis Research
- Vascular Procedures and Complications
- Immunotherapy and Immune Responses
- Emergency and Acute Care Studies
- Immune Response and Inflammation
- Blood Pressure and Hypertension Studies
- Trauma and Emergency Care Studies
- Sphingolipid Metabolism and Signaling
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Network Traffic and Congestion Control
- Air Quality Monitoring and Forecasting
- Foreign Body Medical Cases
Wan Fang Hospital
2017-2025
Taipei Medical University
2017-2025
Taipei Medical University-Shuang Ho Hospital
2024
Fistula Foundation
2022
Weatherford College
2022
National Taiwan University Hospital
2009-2016
Memorial Hospital of South Bend
2015
National Health Research Institutes
2013-2014
National Chin-Yi University of Technology
2014
Landseed Hospital
2014
Abstract The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this during clinical course remains unclear. In study, mutations were identified 7% 500 de novo AML and 58.8% CK. closely associated older age, lower white blood cell (WBC) platelet counts, FAB M6 subtype, unfavorable-risk cytogenetics CK, negatively NPM1 mutation, FLT3/ ITD DNMT3A mutation. Multivariate analysis demonstrated that was an independent...
Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in patients with myelodysplastic syndrome (MDS), but interaction this mutation other genetic alterations and its dynamic changes during disease progression remain to be determined. In study, ASXL1 106 (22.7%) 466 primary MDS based on French-American-British (FAB) classification 62 (17.1%) 362 World Health Organization (WHO) classification. was closely associated trisomy 8 RUNX1, EZH2, IDH, NRAS, JAK2, SETBP1...
Abstract Background Tryptophan metabolites have been suggested to play a role in immune modulation, wherein those recently shown be endogenous ligands of aryl hydrocarbon receptor ( A h R ; unique cellular chemical sensor). However, the involvement tryptophan and modulating mast cell function remains fully defined. We therefore investigated that functional impacts on human mouse responses vitro their importance vivo . Methods Three metabolites, kynurenine KYN ), kynurenic acid KA )...
The burden of chronic liver disease (CLD) deaths attributable to the hepatitis B virus (HBV) and C (HCV) remains unknown. Further research is required elucidate extent this in eventual elimination these diseases.
The gene, CRTH2, encoding a receptor for prostaglandin D2 (PGD2), is located within the peak linkage region asthma on chromosome (Chr.) 11q reported in African American families. Family-based analysis of and two common SNPs [G1544C G1651A (rs545659)] 3′-untranslated CRTH2 showed significant evidence presence disequilibrium 1651G allele (P=0.003) SNP rs545659. Haplotype yielded additional 1544G–1651G haplotype (P<0.001). Population-based case–control analyses were conducted independent...
In hospitalized patients, acute kidney injury (AKI) is an important adverse event associated with high mortality and medical costs. Accurate diagnosis timely management of AKI are essential for improving the outcomes in-hospital AKI, delayed or misdiagnosis hinders advancements in care. To ameliorate this problem, several electronic alert systems have been proposed but shown inconsistent effects on outcomes. Before can improve outcomes, it to confirm their diagnostic accuracy. The purposes...
<title>Abstract</title> Introduction: Postoperative leakage is a critical complication after bariatric surgery, necessitating early and accurate detection. Conventional markers like C-reactive protein (CRP) white blood cell (WBC) counts are often limited by low specificity due to nonspecific inflammatory responses. Procalcitonin (PCT), marker more specific bacterial infections, may improve diagnostic reliability. This study compared the performance of PCT with CRP, WBC, ΔWBC...
Ambient air pollution poses a significant risk for group of common and often debilitating respiratory diseases, but its direct impact on cause-specific diseases using emergency room visit (ERV) as an indicator remains to be fully explored. In this study, we conducted time-series study ambient PM2.5, NO2, SO2 their association with ERV asthma, COPD pneumonia in four-year time span. Relative risks per log increase the level pollutants lags up 10 days were calculated, generalized additive model...
Early determination of the severity Community-Acquired Pneumonia (CAP) is essential for better disease prognosis. Current predictors are suboptimal, and their clinical utility remains to be defined, highlighting need developing biomarkers with efficacious prognostic value. Sphingosine-1-phosphate (S1P) a bioactive sphingolipid documented regulatory role in immune defense maintenance endothelial barrier integrity. For early diagnose CAP recognition severe patients, we conduct this pilot study...
Background Adult asthma is phenotypically heterogeneous with unclear aetiology. We aimed to evaluate the potential contribution of environmental exposure and its ensuing response heterogeneity. Methods Environmental risk was evaluated by assessing records National Health Insurance Research Database (NHIRD) residence-based air pollution (particulate matter diameter less than 2.5 micrometers (PM ) PM -bound polycyclic aromatic hydrocarbons (PAHs)), integrating biomonitoring analysis...
Angiogenic factors have an essential role in normal and pathologic angiogenesis. However, the clinical implication of angiogenic factor expression myelodysplastic syndromes (MDS) remains unclear. In this study, we sought to investigate prognostic impact genes encoding angiopoietin-1 (Ang-1), Ang-2, receptor Tie2, vascular endothelial growth factor-A (VEGF-A) VEGF-C bone marrow (BM) 208 patients with newly diagnosed primary MDS. BM Ang-1 was significantly higher MDS patients, especially those...
Background The innate pattern recognition C-type-lectin receptors (CLRs), including mannose receptor (MRC1; CD206), have been suggested to functionally interact with allergens and are critical in controlling immune response. Fibrocytes considered play a role allergic asthma. Here we sought investigate the functional interaction of cockroach CD206 fibrocytes. Methods Profiling N-linked glycans from natural purified allergen Bla g 2 was accomplished by MALDI-MS. binding activity determined...