A5031368931- Heavy Metal Exposure and Toxicity
- Pancreatic function and diabetes
- Mercury impact and mitigation studies
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Dermatological diseases and infestations
- Phagocytosis and Immune Regulation
- Trace Elements in Health
- Antibiotic Resistance in Bacteria
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Renal Transplantation Outcomes and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Bacterial biofilms and quorum sensing
- Muscle Physiology and Disorders
- Melamine detection and toxicity
- Organ Donation and Transplantation
- Air Quality and Health Impacts
- Metabolism, Diabetes, and Cancer
- Tea Polyphenols and Effects
- Peripheral Artery Disease Management
- Vitamin C and Antioxidants Research
- Diabetic Foot Ulcer Assessment and Management
- Vibrio bacteria research studies
China Medical University
2016-2025
Asia University
2016-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2020-2021
China Medical University
2011-2018
National Health and Family Planning Commission
2018
Tri-Service General Hospital
2017
China Medical University Hospital
2008-2015
National Taiwan University
2008-2012
Chang Gung Memorial Hospital
1998
Chang Gung University
1998
Inflammatory markers such as interleukin (IL)-6 and tumour necrosis factor-alpha (TNF-α) are elevated in dialysis patients can predict cardiovascular events all-cause mortality. Endotoxin is an important source also another marker of inflammation with chronic kidney disease. The aim this study was to evaluate the impact oral probiotics on serum levels endotoxemia cytokines peritoneal (PD) patients. decline residual renal function, peritonitis episodes, were recorded. From July 2011 June...
Cadmium (Cd), one of well-known highly toxic environmental and industrial pollutants, causes a number adverse health effects diseases in humans. The growing epidemiological studies have suggested possible link between Cd exposure diabetes mellitus (DM). However, the toxicological underlying mechanisms Cd-induced pancreatic β-cell injury are still unknown. In this study, we found that significantly decreased cell viability, increased sub-G1 hypodiploid cells annexin V-Cy3 binding...
The incidence of low birth weights is increased in offspring women who are exposed to high concentrations arsenic drinking water compared with other women. We hypothesized that effects on weight may be related myogenic differentiation.We investigated the trioxide (As2O3) differentiation myoblasts vitro and muscle regeneration vivo.C2C12 primary mouse human were cultured media or without As2O3 (0.1-0.5 microM) for 4 days. Myogenic was assessed by myogenin myosin heavy chain expression...
The therapeutic effect of pterosin A, a small-molecular-weight natural product, on diabetes was investigated. Pterosin administered orally for 4 weeks, effectively improved hyperglycemia and glucose intolerance in streptozotocin, high-fat diet–fed, db/db diabetic mice. There were no adverse effects normal or mice treated with A weeks. significantly reversed the increased serum insulin resistance (IR) dexamethasone-IR reduced muscle GLUT-4 translocation liver phosphoenolpyruvate carboxyl...
Epidemiological studies have reported that the prevalence of diabetes in women > 40 years age, especially those postmenopausal phase, was higher than men areas with high levels arsenic drinking water. The detailed effect on glucose metabolism/homeostasis condition is still unclear.We investigated effects at doses relevant to human exposure from water blood regulation estrogen-deficient female mice.Adult mice who underwent ovariectomy or sham surgery were exposed contaminated trioxide (0.05...
Methylmercury (MeHg), a long-lasting organic pollutant, is known to induce cytotoxic effects in mammalian cells. Epidemiological studies have suggested that environmental exposure MeHg linked the development of diabetes mellitus (DM). The exact molecular mechanism MeHg-induced pancreatic β-cell cytotoxicity still unclear. Here, we found (1-4 μM) significantly decreased insulin secretion and cell viability β-cell-derived RIN-m5F A concomitant elevation mitochondrial-dependent apoptotic events...
Paraquat (PQ), a toxic and nonselective bipyridyl herbicide, is one of the most extensively used pesticides in agricultural countries. In addition to pneumotoxicity, liver an important target organ for PQ poisoning humans. However, mechanism hepatotoxicity remains unclear. this study, we found that exposure rat hepatic H4IIE cells (0.1–2 mM) induced significant cytotoxicity apoptosis, which was accompanied by mitochondria-dependent apoptotic signals, including loss mitochondrial membrane...
Klebsiella pneumoniae is the predominant pathogen isolated from liver abscesses of diabetic patients in Asian countries. However, effects elevated blood glucose levels on virulence this remain largely unknown. Type 3 fimbriae, encoded by mrkABCDF genes, are important factors K. pathogenesis. In study, exogenous and intracellular cyclic AMP (cAMP) signaling pathway type fimbriae expression regulation were investigated. The production MrkA, major subunit was increased glucose-rich medium,...
Tongue squamous cell carcinoma (SCC) is a most common type of oral cancer. Due to its highly invasive nature and poor survival rate, the development effective pharmacological therapeutic agents urgently required. Quercetin (3,3',4',5,7‑pentahydroxyflavone) polyphenolic flavonoid found in plants an active component Chinese herbal medicine. The present study investigated effects possible mechanisms quercetin on apoptosis tongue SCC‑derived SAS line. Following treatment with quercetin,...
Objectives The HIV epidemic is worsening among men who have sex with ( MSM ) in China, especially those are younger than 25 years old [younger YMSM )]. aim of the study was to compare prevalences incidence and recent infection as well factors associated older OMSM ). Methods A multicentre cross‐sectional survey conducted 4496 recruited from seven Chinese cities. were defined aged < years. Data on demographics sexual behaviours collected using structural questionnaires. Blood samples...
Bladder cancer is a common malignancy worldwide. However, there still no effective therapy for bladder cancer. In this study, we investigated the cytotoxic effects of cantharidin [a natural toxin produced (pure compound) from Chinese blister beetles (Mylabrisphalerata or Mylabriscichorii) and Spanish flies (Cantharis vesicatoria)] in human cell lines (including: T24 RT4 cells). Treatment cells with significantly decreased viability. The increase expressions caspase-3 activity cleaved form...