A5100456837- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Ureteral procedures and complications
- Vascular anomalies and interventions
- Cancer-related molecular mechanisms research
- Kidney Stones and Urolithiasis Treatments
- Pulmonary Hypertension Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Minimally Invasive Surgical Techniques
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Prostate Cancer Treatment and Research
- Genital Health and Disease
- Urinary Bladder and Prostate Research
- Potassium and Related Disorders
- Pregnancy-related medical research
- Asthma and respiratory diseases
- Nursing Diagnosis and Documentation
Army Medical University
2025
Southwest Hospital
2025
University of Electronic Science and Technology of China
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Capital Medical University
2013-2023
Beijing Children’s Hospital
2013-2023
Xiangshan County First People's Hospital
2023
Jiangxi Provincial People's Hospital
2022
Nanchang University
2022
Abstract Renal fibrosis is a common pathological process that occurs with diverse etiologies in chronic kidney disease. However, its regulatory mechanisms have not yet been fully elucidated. Ferroptosis form of non-apoptotic regulated cell death driven by iron-dependent lipid peroxidation. It currently unknown whether ferroptosis initiated during unilateral ureteral obstruction (UUO)-induced renal and role has determined. In this study, we demonstrated induced tubular epithelial cells (TECs)...
Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in hypertension (PAH). Both the Warburg effect and platelet-derived growth factor (PDGF) are involved PASMCs. However, mechanism underlying crosstalk between PDGF during PASMC still unknown. We hypothesized that promotes via activating phosphatidylinositol 3-kinase (PI3K) signaling pathway hypoxia-inducible 1-α (HIF-1α) proliferative Methods: PASMCs were derived...
Abstract While cancer-associated fibroblasts (CAFs) in the tumour microenvironment may play important roles bladder cancer (BCa) progression, their impacts on BCa chemoresistance remain unclear. Using human samples, we found that tissues possessed more CAFs than did adjacent normal tissues. Both presence of stroma and expression ERβ contribute to chemoresistance, cells interact affect expression. In vitro co-culture assays demonstrated compared with cells, had a higher capacity induce...
Renal fibrosis is a key factor in chronic kidney disease (CKD).Long non-coding RNAs (lncRNAs) play important roles the physiological and pathological progression of human diseases.However, underlying mechanisms lncRNAs renal still need to be discovered.In this study, we first displayed increased lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression patients with obstructive nephropathy (ON).Then found that transforming growth beta (TGF-β1) induced...
Context Renal interstitial fibrosis (RIF) is characterized by the accumulation of inflammatory cytokines and epithelial-mesenchymal transition (EMT). Curcumin exerts antifibrogenic, anti-inflammatory antiproliferative effects.Objective To explore mechanisms underlying effects curcumin on RIF.Materials methods Eight-week-old male C57BL/6 mice were intragastrically administered (50 mg/kg/day) for 14 days after undergoing unilateral ureteral obstruction (UUO) operations. function (blood urea...
To investigate the effects of CCL21/CCR7 on proliferation, migration, and invasion T24 cells possible associated mechanisms: expression MMP-2 MMP-9, regulation BCL-2 BAX proteins.T24 received corresponding treatments including vehicle control, antibody (20 ng/mL CCR7 50 ng/ml CCL21), 50, 100, 200 CCL21. Proliferation was evaluated by MTT assay; cell migration were assayed using a transwell chamber. Cell apoptosis induced Adriamycin (ADM). The rate examined flow cytometry annexin V-FITC/PI...
Compelling evidence suggests that benign prostatic hyperplasia (BPH) development involves accumulation of mesenchymal-like cells derived from the epithelium by epithelial-mesenchymal transition (EMT). Transforming growth factor (TGF)-β induces EMT phenotypes with low E-cadherin and high vimentin expression in epithelial cells. Here we report LPS/TLR4 signalling down-regulation bone morphogenic protein activin membrane-bound inhibitor (BAMBI), which enhances TGF-β process during hyperplasia....
Abstract Renal fibrosis, the ultimate common pathway of progressive nephropathy, is characterized by excess accumulation and deposition extracellular matrix (ECM) within renal interstitium glomeruli, finally resulting in end‐stage kidney failure. TGFβ1 not only abnormally increased during fibrosis but also involved ECM induction accumulation. Based on bioinformative analyses, phosphatase tensin homolog deleted chromosome ten (PTEN) focal adhesion kinase (FAK) signaling might be functions...
To present our experience and the feasibility of retroperitoneal laparoscopic ureteroureterostomy (LUUS) for treatment retrocaval ureter (RCU).A total 12 patients with RCU underwent LUUS. evaluate segment, we calibrated segment by a number 8F catheter before laparoscopy. A three-port, finger-dissecting removal fat, approach was used. In all cases, after had been released from inferior vena cava (IVC), transected at lower part dilated positioned anterior to IVC. tension-free ureteroureteral...
Patients with gastrointestinal tumors often suffer from poor nutritional status during treatment. Surgery is the main treatment for these patients, but long postoperative recovery period accompanied by digestive and absorption dysfunction, leading to further deterioration of status. Early enteral nutrition support hypothesized be helpful in improving this situation, exact effects have yet studied depth.To observe effect early on patients surgically treated tract tumors, expectation that...
Folliculin (FLCN) is a conserved tumor suppressor gene whose loss associated with the human Birt-Hogg-Dubé (BHD) syndrome. However, its molecular functions remain largely unknown. In this work, we generated Drosophila BHD model through genomic deletion of FLCN (DBHD−). The DBHD mutant larvae grew slowly and stopped development before pupation, displaying various characteristics malnutrition. We found growth delay was sensitive to nutrient supplies. It became more severe upon restrictions...
Purpose: To present our experience and the feasibility with laparoscopic ureteral reimplantation using tapering (intracorporeal or extracorporeal) for symptomatic primary obstructive megaureter. Patients Methods: Between June 2005 September 2010, 11 patients (mean age: 33.2 years) congenital megaureter underwent reconstruction. All intracorporeal extracorporeal tailoring ureteroneocystostomy by same surgical team. The relevant perioperative details complications were recorded. Results: No...
Objectives: The aim of this study was to compare the operative and postoperative outcomes laparoscopic ureteroureterostomy (LAP-UU) using a retrograde ureteroscopy-assisted technique with ureteroneocystostomy (LAP-UNC) in treating ureteral injury after gynecological surgery.Materials methods: analyzed 60 repairs performed between May 2010 February 2016 patients who underwent either LAP-UU (n = 26) or LAP-UNC 34). Demographic parameters, variables perioperative were retrospectively analyzed....
To compare the operative outcomes of obese patients undergoing laparoendoscopic single-site (LESS) retroperitoneoscopic adrenalectomy or standard laparoscopic (LAP) adrenalectomy.Between September 2011 and April 2015, 51 underwent LESS their were compared with 65 who by same surgeon. In group, a single-port access was positioned in lumbar incision. The retroperitoneal technique performed combination conventional curved LAP instruments. following parameters adopted: patient demographics,...
Granulocyte colony-stimulating factor (G-CSF) has exhibited efficacy at preventing the progression of pulmonary hypertension (PH); however, exact mechanism is not completely clear. The aim present study was to assess whether this protective effect mediated by upregulation circulating endothelial progenitor cells (EPCs) via nitric oxide (NO) system. PH induced in male Sprague-Dawley (SD) rats administration a single subcutaneous injection monocrotaline (MCT). were treated with recombinant...
To present our experience of combining transperitoneal mini-laparoscopic pyeloplasty (mini-LP) and concomitant ureteroscopy-assisted pyelolithotomy (U-P) for ureteropelvic junction obstruction (UPJO) complicated by renal caliceal stones in the same session.Between May 2007 December 2011, mini-LP U-P was performed nine patients with UPJO ipsilateral stones. Stone location burden were preoperatively assessed. After pyelotomy appropriate length (about 4 mm), a 16-Fr catheter sheath replaced...
Symptomatic seminal vesicle cysts (SVCs), especially those of a large size, can be removed by surgical treatments. Currently, open surgeries for SVC are rarely performed due to their extensive trauma, and minimally invasive therapies treating still in the early stages. In addition, relevant studies mostly confined case reports. this study, we retrospectively reviewed 53 patients who had received transperitoneal laparoscopic unroofing or fenestration under vesiculoscopy our institution. Both...
Aim and objectivesThis study aimed to identify symptom cluster (SC) patterns change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), the correlation SCs laboratory imaging indicators, intrinsic association prognostic outcomes burden.MethodSymptom information was collected using a digital evaluation scoring system at time admission, on third day after upon discharge. Laboratory examination data were compiled simultaneously. Exploratory factor...