A5034954639- Enzyme Production and Characterization
- Biofuel production and bioconversion
- Microbial Metabolites in Food Biotechnology
- Studies on Chitinases and Chitosanases
- Acute Ischemic Stroke Management
- Polysaccharides and Plant Cell Walls
- Enzyme Catalysis and Immobilization
- Carbohydrate Chemistry and Synthesis
- Essential Oils and Antimicrobial Activity
- Glycosylation and Glycoproteins Research
- Pineapple and bromelain studies
- Plant-Microbe Interactions and Immunity
- Cerebrovascular and Carotid Artery Diseases
- Chinese history and philosophy
- Nanocomposite Films for Food Packaging
- Ginger and Zingiberaceae research
- Probiotics and Fermented Foods
- Plant biochemistry and biosynthesis
- Higher Education and Teaching Methods
- Spectroscopy Techniques in Biomedical and Chemical Research
- Phytochemistry and Biological Activities
- Fungal Biology and Applications
- PARP inhibition in cancer therapy
- Educational Reforms and Innovations
- Membrane Separation Technologies
Shanghai University
2020-2025
Shandong University
2025
Xinjiang University
2025
Qingdao University of Science and Technology
2024
Qingdao University of Technology
2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Hong Kong University of Science and Technology
2015-2021
University of Hong Kong
2015-2021
Experimental Station
2021
Abstract In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior clinical and biological applications. While in vitro studies have increasing constantly, vivo not established a unified system until now. Predictive models validated standard methods are imperative. This review summarizes current progress approaches assessing nanotoxicity main systems, including hepatic renal, gastrointestinal, pulmonary, cardiovascular, nervous, immune systems....
Protein engineering is a powerful strategy for enhancing the properties of enzymes industrial applications. However, thermostabilizing an enzyme via this while simultaneously improving its activity challenging due to well-known stability–activity trade-off. Herein, using native ketoreductase LbCR, thermostability and were evolved separately by directed evolution, generating mutations V198I M154I/A155D with increased A201D/A202L enzymatic activity. On basis additivity cooperative mutational...
Pamiparib, an investigational Poly (ADP-ribose) polymerase (PARP) inhibitor in clinical development, demonstrates excellent selectivity for both PARP1 and PARP2, superb anti-proliferation activities tumor cell lines with BRCA1/2 mutations or HR pathway deficiency (HRD). Pamiparib has good bioavailability is 16-fold more potent than olaparib efficacy study using BRCA1 mutated MDA-MB-436 breast cancer xenograft model. also shows strong anti-tumor synergy temozolomide (TMZ), a DNA alkylating...
Poly (ADP-ribose) polymerase (PARP) plays a significant role in DNA repair responses; therefore, this enzyme is targeted by PARP inhibitors cancer therapy. Here we have developed number of fused tetra- or pentacyclic dihydrodiazepinoindolone derivatives with excellent enzymatic and cellular PARylation inhibition activities. These efforts led to the identification pamiparib (BGB-290, 139), which displays PARP-1 PARP-2 IC50 1.3 0.9 nM, respectively. In assay, compound inhibits activity = 0.2...
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, characterized by invasiveness, local lymph node metastasis, and poor prognosis. Traditional treatment medications have limitations, making specific inhibition OSCC growth, invasion, metastasis a challenge. The tumor microenvironment exhibits mildly acidity high concentrations H
Bacillus subtilis is commonly used as a biocontrol bacterium owing to its strong antifungal activity, broad-spectrum inhibition, and general safety. In this study, the inhibitory effects of volatile organic compounds (VOCs) produced by B. CF-3 on Colletotrichum gloeosporioides, major destructive phytopathogen litchi anthracnose, were analyzed using proteomics transcriptomics. Differentially expressed genes (DEGs) proteins (DEPs) indicated that inhibition C. gloeosporioides VOCs downregulated...
Chemical components are one of the most significant traits and attributes plant tissues, lead to their different functions. In this study, composition Amomun tsao-ko essential oils (AEOs) from regions was first determined by a combination gas chromatography-mass spectrometry (GC-MS) chromatography-ion mobility (GC-IMS). total, 141 compounds were identified, which terpenes aldehydes main groups. Orthogonal partial least square discriminant analysis (OPLS-DA) distinguished samples clearly,...
Amomum tsaoko is a medicinal and edible plant mainly distributed in southwest China Southeast Asia. This study investigated the antibacterial activity of essential oil (AEO) against typical foodborne pathogenic bacteria interaction AEO with Staphylococcus aureus. The results showed that exhibited excellent bacteria, most performance S. aureus, MIC MBC values 0.20 mg/mL 0.39 mg/mL, respectively. In addition, effects on aureus might include affecting cell membrane permeability, integrity,...
β-1,3-Glucan is one of the most abundant polysaccharides in fungi.
γ-Aminobutyric acid (GABA) is a plant resistance elicitor essential in preventing and controlling postharvest disease fruits vegetables. However, limited information available involving the inhibitory effect of exogenous GABA on pathogens. This study found that inhibited pathogenic fungus, Alternaria alternata (A. alternata). Transcriptome analysis revealed genes related to sporulation, toxin synthesis, cell wall degradation enzymes are downregulated A. after treatment. Moreover, was...
β-1,3-Glucan-degrading enzymes are widely used in fields such as food processing, plant protection, and breweries. In this work, we identified a glycoside hydrolase (GH) family 157 endo-β-1,3-glucanase (BsGlc157A) from Bacteroides sp. M27 characterized its biochemical properties, structural model, antifungal activity. Enzymological characterization indicated that BsGlc157A performs optimal catalytic activity at pH 6.0 40 °C. adopted the classic (β/α)8 TIM-barrel structure. Two residues,...