A5011932869- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Cervical Cancer and HPV Research
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Retinoids in leukemia and cellular processes
- Eosinophilic Esophagitis
- Cancer-related molecular mechanisms research
- Arsenic contamination and mitigation
- Polyomavirus and related diseases
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Environmental Sustainability and Technology
- Ubiquitin and proteasome pathways
- QR Code Applications and Technologies
- Digitalization and Economic Development in Agriculture
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Cell death mechanisms and regulation
George Washington University
2022-2024
Siberian State University Geosystems and Technology
2020-2021
Columbia University Irving Medical Center
2019
Cancer Genetics (United States)
2018
Columbia University
2015-2018
Herbert Irving Comprehensive Cancer Center
2018
New York University
2002-2010
Russian Academy of Sciences
1992
Abstract Objective The recurrence rate of anti‐SSA/Ro–associated congenital heart block (CHB) is 17%. Sustained reversal third‐degree has never been achieved. Based on potential reduction maternal autoantibody titers as well fetal inflammatory responses, intravenous immunoglobulin (IVIG) was evaluated preventive therapy for CHB. Methods A multicenter, prospective, open‐label study based Simon's 2‐stage optimal design initiated. Enrollment criteria included the presence anti‐SSA/Ro antibodies...
Abstract Polo-like kinase 3 (Plk3) is an important mediator of the cellular responses to genotoxic stresses. In this study, we examined physiologic function Plk3 by generating Plk3-deficient mice. Plk3−/− mice displayed increase in weight and developed tumors various organs at advanced age. Many were large size, exhibiting enhanced angiogenesis. mouse embryonic fibroblasts hypersensitive induction hypoxia-inducible factor-1α (HIF-1α) under hypoxic conditions or nickel cobalt ion treatments....
Abstract Activation of TLR by ssRNA after FcγR-mediated phagocytosis immune complexes (IC) may be relevant in autoimmune-associated congenital heart block (CHB) where the obligate factor is a maternal anti-SSA/Ro Ab and fetal factors, protein/RNA on an apoptotic cardiocyte infiltrating macrophages. This study addressed hypothesis that Ro60-associated ssRNAs link macrophage activation to fibrosis via engagement. Both transfection with noncoding bind Ro60 IC generated incubation Ro60-ssRNA IgG...
microRNAs (miRNAs) play key roles in cancer, but their propensity to couple targets as competing endogenous RNAs (ceRNAs) has only recently emerged. Multiple models have studied ceRNA regulation, these did not account for the effects of co-regulation by miRNAs with many targets. We modeled and simulated its using established parameters miRNA/mRNA interaction kinetics while accounting multiple Our simulations suggested that miRNA species is more likely produce physiologically relevant...
Binding of maternal anti-Ro/La antibodies to cognate antigen expressed on apoptotic cardiocytes decreases clearance by healthy cardiocytes, which may contribute the development autoimmune associated congenital heart block and fatal cardiomyopathy.
The diverse roles of protein kinase C-δ (PKCδ) in cellular growth, survival, and injury have been attributed to stimulus-specific differences PKCδ signaling responses. exerts membrane-delimited actions cells activated by agonists that stimulate phosphoinositide hydrolysis. is released from membranes as a Tyr(313)-phosphorylated enzyme displays high level lipid-independent activity altered substrate specificity during oxidative stress. This study identifies an interaction between PKCδ's hinge...
The main risk factor for esophageal dysplasia and adenocarcinoma (DAC) is Barrett's esophagus (BE), characterized by intestinal metaplasia. critical genomic mechanisms that lead to progression of nondysplastic BE DAC remain poorly understood require analyses longitudinal patient cohorts high‐resolution assays. We tested tissues from 74 patients, including 42 nonprogressors two separate groups 21 patients each 32 progressors (16 in a cohort before DAC/preprogression‐BE 16 with temporally...
Loss of heterozygosity (LOH) in chromosome 6 human squamous cervical carcinomas was analyzed the long and short arms using 3 pairs primers each. In all cases, normal adjacent tissue used as control. Among 51 cases analyzed, we identified LOH or microsatellite instability 23% primer D6S291 (located at position 6p21.3) 11% D6S308 (6q16.3-6q27) D6S270 (6q22.3-6q23.2). On contrary, no significant genomic instabilities were detected with D6S306 (6p22.3-6p21.2), D6S299 (6p22.3-6p21.3) D6S287...
To understand if there exists a functional interaction between arsenic trioxide and paclitaxel in vitro.HeLa HCT116 (rho53(+/+) rho53(-/-)) cells were treated with As2O3 and/or for various times. Treated collected analyses using combination of flow cytometry, fluorescence microscopy Western blotting.Because As(2)O(3) is capable inhibiting tubulin polymerization inducing mitotic arrest, we examined whether existed any paclitaxel, well-known microtubule poison. Flow cytometry revealed that...
Рассматриваются условные обозначения карт служб спасения.Приведен качественный анализ структуры стандарта ГОСТ Р 42.0.03-2016и предложена полученная на его основе классификация существующих условных обозначений.Исследуется зарубежный опыт применения обозначений спасения в США, Австралии, Японии и Евросоюза.Описаны результаты проведенного онлайн-опроса, направленного выявление ассоциативного соотнесения служб, участвующих ликвидации чрезвычайных ситуаций (ЧС), с цветами, отобранными для...
Modern natural language processing technologies allow you to work with texts without being a specialist in linguistics. The use of popular data platforms for the development and linguistic models provides an opportunity implement them geographic information systems. This feature allows significantly expand functionality improve accuracy standard geocoding functions. article comparison most methods software implemented on their basis, using example solving problem extracting geographical...
// Armando Del Portillo 1 , Elena V. Komissarova Aqiba Bokhari Caitlin Hills Anne Koehne de Gonzalez Sarawut Kongkarnka Helen E. Remotti Jorge L. Sepulveda and Antonia R. Department of Pathology Cell Biology, Columbia University Irving Medical Center, New York, NY, USA Correspondence to: Sepulveda, email: as4400@cumc.columbia.edu Keywords: gastric cancer; FLI1; dysplasia; tumor suppressor; methylation Received: November 29, 2018     Accepted: April 04,...
Despite a good enough degree so traditional printed maps, however you can still find new ways to increase information card capacity and thus partially resolve the existing contradiction between clarity readability of maps. One such way is use QR code technology. The article describes basic features codes, ensure that interest in this research identified number advantages using codes when creating cards. Technology with cartography has both scientific practical value terms cards for various...
CDKN2A-p16 deletion in LGR5+ stem cell progenitors the stomach squamocolumnar junction triggers increased mucous-gland hyperplasia/metaplasia.Oncogenic KRAS G12D synergizes with p16deletion resulting higher-grades of glandular dysplasia, supporting a functional role p16 and progression Barrett's-like lesions to dysplasia.
The article discusses the development directions of cartographic methods to provide users with geoinformation using modern digital devices. Explains need review substantive essence, system symbols, use, information content and peculiarity perception by users. A new method support needs economy society, which is based on a combination capabilities analog traditional maps, mobile multimedia cartography, substantiated proposed. Various ways increasing volume maps special markers them, files...